Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyond

European Journal of Clinical Investigation, Год журнала: 2021, Номер 51(5)

Опубликована: Янв. 4, 2021

The new coronavirus (SARS-CoV-2) appearance in Wuhan, China, did rise the virus disease (COVID-19), which spread globally a short time, leading World Health Organization to declare global pandemic. To contain and mitigate of SARS-CoV-2, specific public health procedures were implemented virtually all countries, with significant impact on society, making it difficult keep regular practice physical activity. It is widely accepted that an active lifestyle contributes improvement general preservation cardiovascular, respiratory, osteo-muscular immune system capacities. positive effects activity have emerged as pivotal trigger health, underlying beneficial multiple physiological systems. Accordingly, recent studies already pointed out negative inactivity caused by social isolation imposed sanitary authorities due COVID-19. Nevertheless, there are still no current narrative reviews evaluating real COVID-19 or even discussing possible exercise-promoted upgrade against severity progression Based consensus scientific literature, this review, we discuss how exercise adherence could adequately improve responses times 'COVID-19 Era beyond'.

Язык: Английский

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Immunomodulation Effect of Biomaterials on Bone Formation

Journal of Functional Biomaterials, Год журнала: 2022, Номер 13(3), С. 103 - 103

Опубликована: Июль 25, 2022

Traditional bone replacement materials have been developed with the goal of directing osteogenesis osteoblastic cell lines toward differentiation and therefore achieving biomaterial-mediated osteogenesis, but osteogenic effect has disappointing. With advances in biology, it revealed that local immune microenvironment an important role regulating formation process. According to immunology hypothesis, system skeletal are inextricably linked, many cytokines regulatory factors common, cells play essential bone-related physiopathological processes. This review combines biomaterial immunomodulatory properties provide overview biomaterials-mediated responses regulate regeneration, as well methods assess biomaterials how these strategies can be used for future tissue engineering applications.

Язык: Английский

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Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System

Biomolecules, Год журнала: 2023, Номер 13(5), С. 816 - 816

Опубликована: Май 11, 2023

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning knowledge that disease intimately tied to neurodegenerative disorders, affecting both central and peripheral nervous systems well leading dementia, seventh cause of death. New innovative therapeutic strategies address metabolism, apoptosis, autophagy, pyroptosis, mechanistic target rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), risk factors apolipoprotein E (APOE-ε4) gene coronavirus 2019 (COVID-19) can offer valuable insights for clinical care treatment disorders impacted by disease. Critical insight into modulation these complex pathways are required since mTOR pathways, AMPK activation, improve memory retention in Alzheimer's (AD) DM, promote healthy aging, facilitate clearance β-amyloid (Aß) tau brain, control inflammation, but also may lead cognitive loss long-COVID syndrome through mechanisms include oxidative stress, mitochondrial cytokine release, APOE-ε4 if autophagy other programmed cell death left unchecked.

Язык: Английский

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The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease

Current Neurovascular Research, Год журнала: 2023, Номер 20(3), С. 314 - 333

Опубликована: Июль 25, 2023

Disorders of metabolism affect multiple systems throughout the body but may have greatest impact on both central and peripheral nervous systems. Currently available treatments behavior changes for disorders that include diabetes mellitus (DM) system diseases are limited cannot reverse disease burden. Greater access to healthcare a longer lifespan led an increased prevalence metabolic neurodegenerative disorders. In light these challenges, innovative studies into underlying pathways offer new treatment perspectives Alzheimer's Disease, Parkinson's Huntington's Disease. Metabolic intimately tied can lead debilitating outcomes, such as multi-nervous disease, susceptibility viral pathogens, long-term cognitive disability. Novel strategies robustly address involve careful consideration cellular metabolism, programmed cell death pathways, mechanistic target rapamycin (mTOR) its associated mTOR Complex 1 (mTORC1), 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor signaling, risk factors apolipoprotein E (APOE-ε4) gene. Yet, complex necessitate comprehensive understanding achieve clinical outcomes susceptibility, onset, progression.

Язык: Английский

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Inflammation in COVID-19 and the Effects of Non-Pharmacological Interventions during the Pandemic: A Review

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15584 - 15584

Опубликована: Дек. 9, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the disease 2019 (COVID-19) pandemic that hit health systems worldwide hard, causing a collapse of healthcare systems. One main problems this new virus is high inflammatory response it provokes, which cause much symptoms. Different pharmacological approaches tried to stop advance pandemic, but seems only vaccines are solution. In line, different nonpharmacological have been made in order improve symptomatology, contagion, and spread COVID-19, principal factors being physical activity, nutrition, physiotherapy, psychology, life patterns. The SARS-CoV-2 produces disproportionate organism guest causes complications can end patient. It has possible see how interventions based on nutritional, psychological, therapy, lifestyle changes be functional tools treat inflammation. Thus, present review, we aim provide an overview role inflammation COVID-19 related it.

Язык: Английский

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Relationship between physical activity and quality of life among patients with respiratory and digestive system cancer during and outside the COVID-19 pandemic

Supportive Care in Cancer, Год журнала: 2025, Номер 33(4)

Опубликована: Март 17, 2025

Язык: Английский

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The reactivation of the various types of viruses following COVID-19 infection: a systematic review

Future Virology, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Март 27, 2025

Язык: Английский

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Does pre-existent physical inactivity have a role in the severity of COVID-19?

Therapeutic Advances in Respiratory Disease, Год журнала: 2021, Номер 15

Опубликована: Янв. 1, 2021

Background and Aims: Physical inactivity is considered an important lifestyle factor for overweight cardiovascular disease. We aimed to investigate the association between pre-existent physical risk of severe coronavirus disease 2019 (COVID-19). Methods: included 164 (61.8 ± 13.6 years) patients with COVID-19 who were admitted 15 February 14 March 2020 in this retrospective study. evaluated using a logistic regression model. Results: Of eligible COVID-19, 103 (62.8%) reported be physically inactive. Univariable analysis showed that was associated increased [unadjusted odds ratio (OR) 6.53, 95% confidence interval (CI) 1.88–22.62]. In multivariable analysis, remained significantly (adjusted OR 4.12, CI 1.12–15.14) after adjustment age, sex, stroke, overweight. Conclusion: Our data experiencing COVID-19. findings indicate people should encouraged keep active at lower illness when infection seems unpredicted. The reviews paper are available via supplemental material section.

Язык: Английский

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Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8+ T-Cell Profiles

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Окт. 12, 2021

Chronic cytomegalovirus (CMV) infection is a trigger factor for the development of immunosenescence and negatively impacts immune response to influenza virus vaccination (IVV) in older adults. However, role physical exercise training this context unknown. Thus, aim study was investigate whether regular practice combined can improve specific antibody IVV CMV-seropositive Eighty adults were distributed into two groups—non-practitioners (NP, n = 31, age 74.06 ± 6.4 years) practitioners (CET, 49, 71.7 5.8 years)—for at least 12 months. Both volunteer groups submitted blood samples collected before (pre) 30 days after (post) vaccination. Concerning IVV, higher serum levels immunoglobulin A (IgA) found CET group post- than pre-vaccination ( p < 0.01), whereas M (IgM) observed both NP 0.05) 0.001) post-vaccination as compared values. Serum G (IgG) CMV, well interleukin 6 (IL-6) IL-10, similar between time points evaluated. IL-10/IL-6 ratio that Negative correlations IgG CMV only group, pre- post-vaccination. In addition, negative IL-10 all post-vaccination, positive correlation specific-IgG group. with hemagglutination inhibition (HAI) assay, it 32.2% 32.6% responders displayed reductions serostatus 0.05 0.001, respectively) increases naive effector CD8 + T cells 0.01). from showed significant increased 0.001). summary, demonstrates improvement related an anti-inflammatory status enhancement cells, particularly associated CET.

Язык: Английский

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Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination

Vaccines, Год журнала: 2021, Номер 9(2), С. 107 - 107

Опубликована: Янв. 31, 2021

Background: Although glutamine is able to improve the immune response, its action in upper airway immunity against influenza virus vaccine remains unclear. Therefore, we aimed evaluate L-glutamine supplementation effect on mucosal immune/inflammatory response of elderly subjects vaccinated virus. Methods: Saliva sampling from 83 physically active volunteers were collected pre- and 30 days after vaccination with (Gln, n = 42) or placebo (PL, 41). Results: Gln group showed higher salivary levels interleukin (IL)-17, total secretory immunoglobulin A (SIgA), specific-SIgA post-vaccination than values found pre-vaccination PL post-vaccination. Whereas IL-6 IL-10 observed group, IL-37 lower both groups pre-vaccination. Tumor necrosis factor (TNF)-α unchanged. Positive correlations between all volunteer also IL-17 negative correlation was group. Conclusion: modulate cytokine profile increase SIgA levels, specific vaccine, subjects.

Язык: Английский

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