Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(31), С. 7480 - 7496
Опубликована: Янв. 1, 2024
The development of various osteogenic biomaterials has not only promoted the bone tissue engineering but also provided more possibilities for defect repair.
Язык: Английский
Materials Today Bio, Год журнала: 2023, Номер 20, С. 100636 - 100636
Опубликована: Апрель 15, 2023
Strontium (Sr) and strontium ranelate (SR) are commonly used therapeutic drugs for patients suffering from osteoporosis. Researches have showed that Sr can significantly improve the biological activity physicochemical properties of materials
Язык: Английский
Процитировано
42
Biomimetics, Год журнала: 2023, Номер 8(1), С. 16 - 16
Опубликована: Янв. 2, 2023
Regenerative medicine has received potential attention around the globe, with improving cell performances, one of necessary ideas for advancements regenerative medicine. It is crucial to enhance performances in physiological system drug release studies because variation environments between vitro and vivo develops a loop estimation. On other hand, tissue engineering path integrate cells scaffold biomaterials produce growth factors regenerate organs. Scaffold are prototype production perform vital functions engineering. Silk fibroin natural fibrous polymer significant usage growing interest leftovers silk Among various biopolymer-based biomaterials, fibroin-based have attracted due their outstanding mechanical properties, biocompatibility, hemocompatibility, biodegradability applications. This review article focused on highlighting recent 3D printing technologies
Язык: Английский
Процитировано
28
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Фев. 12, 2024
Abstract Background Coordination between osteo-/angiogenesis and the osteoimmune microenvironment is essential for effective bone repair with biomaterials. As a highly personalized precise biomaterial suitable repairing complex defects in clinical practice, it to endow 3D-printed scaffold above key capabilities. Results Herein, by introducing xonotlite nanofiber (Ca 6 (Si O 17 ) (OH) 2 , CS) into silk fibroin/gelatin basal scaffold, novel system named SGC was fabricated. It noted that incorporation of CS could greatly enhance chemical mechanical properties match needs regeneration. Besides, benefiting from addition CS, scaffolds accelerate osteo-/angiogenic differentiation mesenchymal stem cells (BMSCs) meanwhile reprogram macrophages establish favorable microenvironment. In vivo experiments further demonstrated efficiently stimulate create regeneration-friendly Mechanistically, we discovered may achieve immune reprogramming through decrease expression Smad6 Smad7, both which participate transforming growth factor-β (TGF-β) signaling pathway. Conclusion Overall, this study potential due its pro-osteo-/angiogenic osteoimmunomodulatory properties. addition, promising strategy develop biomaterials taking osteoinduction remodeling functions account. Graphical
Язык: Английский
Процитировано
14
Small, Год журнала: 2024, Номер 20(46)
Опубликована: Авг. 19, 2024
Titanium and titanium alloys remain the gold standard for dental orthopedic implants. These materials are heavily used because of their bioinert nature, robust mechanical properties, seamless integration with bone. However, implant-associated infections (IAIs) one leading causes implant failure. Eradicating an IAI can be difficult since bacteria form biofilms on medical implant, protecting bacterial cells against systemic antibiotics host's immune system. If infection is not treated promptly aggressively, device failure inevitable, to costly multi-step revision surgeries. To circumvent this dire situation, scientists engineers continue develop novel strategies protect surface implants from bacteria. In review, details emerging prevent in reported. include anti-adhesion properties provided by polymers, superhydrophobic, superhydrophilic, liquid-infused coatings, as well coatings employed lyse Additionally, commercially available technologies those under preclinical trials examined while discussing current future trends.
Язык: Английский
Процитировано
10
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(8), С. 216 - 216
Опубликована: Июль 31, 2024
Divalent cations have captured the interest of researchers in biomedical and dental fields due to their beneficial effects on bone formation. These metallic elements are similar trace found human bone. Strontium is a divalent cation commonly various biomaterials. Since strontium has radius calcium, it been used replace calcium many calcium-containing ability inhibit resorption increase deposition, making useful treatment osteoporosis. also as radiopacifier dentistry incorporated into variety materials improve radiopacity. Furthermore, shown antimicrobial mechanical properties materials, promote enamel remineralization, alleviate dentin hypersensitivity, enhance regeneration. The objective this review provide comprehensive applications dentistry.
Язык: Английский
Процитировано
9
Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 879 - 894
Опубликована: Фев. 1, 2023
Abstract: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a disabling disease with high mortality in China but detailed molecular and cellular mechanisms remain to be investigated. Macrophages are considered key cells osteoimmunology, cross-talk between bone macrophages other microenvironment involved maintaining homeostasis. M1 polarized launch chronic inflammatory response secrete broad spectrum cytokines (eg, TNF-α, IL-6 IL-1β) chemokines initiate state GIONFH. M2 macrophage alternatively activated anti-inflammatory type distributed mainly perivascular area necrotic head. In development GIONFH, injured vascular endothelial activate TLR4/NF-κB signal pathway, promote dimerization PKM2 subsequently enhance production HIF-1, inducing metabolic transformation phenotype. Considering these findings, putative interventions by local chemokine regulation correct imbalance M1/M2 switching an phenotype, or inhibiting adoption phenotype appear plausible regimens for preventing intervening GIONFH early stage. However, results were obtained vitro tissue experimental animal model. Further studies completely elucidate alterations polarization functions glucocorticoid-induced imperative. Keywords: osteonecrosis, polarization, osteoimmunity, osteoclast differentiation, osteogenesis, glucocorticoid
Язык: Английский
Процитировано
21
Journal of Oral Biology and Craniofacial Research, Год журнала: 2023, Номер 13(2), С. 210 - 217
Опубликована: Янв. 21, 2023
Diseases such as periodontitis and osteoporosis are expected to rise tremendously by 2050. Bone formation remodeling complex processes that disturbed in a variety of diseases influenced various hormones.This study aimed review present the roles hormones regulate bone craniofacial complex.A literature search was conducted on PubMed Google Scholar for studies related jawbone. Search strategies included combinations ("name hormone" + "dental term") following terms: "hormones", "oxytocin", "estrogen", "adiponectin", "parathyroid hormone", "testosterone", "insulin", "angiotensin", "cortisol", "erythropoietin", combined with dental term "jaw bone", "alveolar implant", regeneration, healing or repair", "dentistry", "periodontitis", "dry socket", "osteoporosis" "alveolitis". The papers were screened according inclusion criteria from January 1, 2000 March 31, 2021 English. Publications reviews, book chapters, original research papers; vitro studies, vivo animal, human including clinical meta-analyses.Bone is continuous process involving many hormones. volume reduction tooth extractions diseases, osteoporosis, cause serious problems require great understanding process.Hormones us all time, shape our development homeostasis. Newly discovered effects influencing open possibilities using therapeutics combat bone-related diseases.
Язык: Английский
Процитировано
15
Advanced Therapeutics, Год журнала: 2023, Номер 6(8)
Опубликована: Май 11, 2023
Abstract Biomaterials have gained immense attention for various diseases due to their unique advantages over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these materials need an inert delivery system that locally delivers cells minimally elicits foreign body response (FBR). In this aspect, immunomodulatory biomaterials, including silk, collagen, fibrin, hyaluronic acid, alginate‐based great potential large natural sources, extraction, low inertness, facile surface functionalization, long‐term polymeric stability, high biocompatibility, fine tunability biomaterials sizes shapes. review article, the recent advancements in biomedical applications different diseases, diabetes, cancer, cardiovascular disease, bone regeneration, etc, are highlighted. Moreover, FBR on is discussed current future strategies mitigation considerable immune responses toward devices
Язык: Английский
Процитировано
14
Acta Biomaterialia, Год журнала: 2024, Номер 183, С. 1 - 29
Опубликована: Май 28, 2024
Язык: Английский
Процитировано
5
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Biomaterials intended for intrabone implantation are extensively utilized in orthopedic and dental applications. Their surface properties, particularly hydrophilicity, significantly influence the biological interactions surrounding implant, ultimately determining implant's
Язык: Английский
Процитировано
5