Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116925 - 116925
Опубликована: Июнь 15, 2024
Macrophages
are
central
to
the
immune
system
and
found
in
nearly
all
tissues.
Recently,
development
of
therapies
based
on
macrophages
has
attracted
significant
interest.
These
utilize
macrophages'
key
roles
immunity,
their
ability
navigate
biological
barriers,
tendency
accumulate
tumors.
This
review
explores
advancement
macrophage-based
treatments.
We
discuss
bioengineering
for
improved
anti-tumor
effects,
use
CAR
macrophage
therapy
targeting
cancer
cells,
as
vehicles
therapeutic
delivery.
Additionally,
we
examine
engineered
products,
like
extracellular
vesicles
membrane-coated
nanoparticles,
potential
precise
less
toxic
tumor
therapy.
Challenges
moving
these
from
research
clinical
practice
also
highlighted.
The
aim
is
succinctly
summarize
current
status,
challenges,
future
directions
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 16, 2024
Photothermal
therapy
(PTT)
is
a
promising
non-invasive
treatment
that
has
shown
great
potential
in
eliminating
tumors.
It
not
only
induces
apoptosis
of
cancer
cells
but
also
triggers
immunogenic
cell
death
(ICD)
which
could
activate
the
immune
system
against
cancer.
However,
immunosuppressive
tumor
microenvironment
(TIME)
poses
challenge
to
triggering
strong
responses
with
single
treatment,
thus
limiting
therapeutic
effect
immunotherapy.
In
this
study,
dual-targeted
nano
delivery
(GOx@FeNPs)
combined
αPD-L1
checkpoint
blocker
inhibit
colorectal
(CRC)
progression
by
mediating
PTT,
ferroptosis
and
anti-tumor
response.
Briefly,
specific
was
achieved
cyclic
arginine
glycyl
aspartate
(cRGD)
peptide
anisamide
(AA)
GOx@FeNPs
had
good
photothermal
realize
PTT
induce
ICD,
deplete
glutathione
(GSH)
catalyze
production
reactive
oxygen
species
(ROS)
from
endogenous
H
Abstract
Triple‐negative
breast
cancer
(TNBC)
is
a
highly
heterogeneous
subtype
of
cancer,
characterized
by
aggressiveness
and
high
recurrence
rate.
As
monotherapy
provides
limited
benefit
to
TNBC
patients,
combination
therapy
emerges
as
promising
treatment
approach.
Gambogic
acid
(GA)
an
exceedingly
anticancer
agent.
Nonetheless,
its
application
potential
hampered
low
drug
loading
efficiency
associated
toxic
side
effects.
To
overcome
these
limitations,
using
mesoporous
polydopamine
(MPDA)
endowed
with
photothermal
conversion
capabilities
considered
delivery
vehicle
for
GA.
Meanwhile,
GA
can
inhibit
the
activity
heat
shock
protein
90
(HSP90)
enhance
effect.
Herein,
GA‐loaded
MPDA
nanoparticles
(GA@MPDA
NPs)
are
developed
rate
75.96%
remarkable
performance.
GA@MPDA
NPs
combined
(PTT)
significantly
tumor
growth,
effectively
trigger
immunogenic
cell
death
(ICD),
which
thereby
increase
number
activated
effector
T
cells
(CD8
+
CD4
cells)
in
tumor,
hoist
level
immune‐inflammatory
cytokines
(IFN‐
γ
,
IL‐
6
TNF‐
α
).
The
above
results
suggest
that
PTT
expected
activate
antitumor
immune
response,
thus
potentially
enhancing
clinical
therapeutic
effect
on
TNBC.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Апрель 11, 2024
Combining
immune
checkpoint
blockade
with
chemotherapy
through
nanotechnology
is
promising
in
terms
of
safety
and
efficacy.
However,
the
distinct
subcellular
distribution
each
ingredient's
action
site
makes
it
challenging
to
acquire
an
optimal
synergism.
Herein,
a
dual-pH
responsive
hybrid
polymeric
micelle
system,
HNP(αPDL1
Abstract
Amplifying
oxidative
stress
within
tumor
cells
can
effectively
inhibit
the
growth
and
metastasis
of
triple‐negative
breast
cancer
(TNBC).
Therefore,
development
innovative
nanomedicines
that
disrupt
redox
balance
represents
a
promising
yet
challenging
therapeutic
strategy
for
TNBC.
In
this
study,
an
amplifier,
denoted
as
PBCH,
comprising
PdAg
mesoporous
nanozyme
CaP
mineralized
layer,
loaded
with
GSH
inhibitor
L‐buthionine
sulfoximine
(BSO),
further
surface‐modified
hyaluronic
acid
target
CD44,
is
introduced.
acidic
microenvironment,
Ca
2+
initially
released,
thereby
leading
to
mitochondrial
dysfunction
eventually
triggering
apoptosis.
Additionally,
BSO
suppresses
synthesis
intracellular
reduced
amplifies
level
in
cells.
Furthermore,
be
activated
by
near‐infrared
light
induce
photothermal
photodynamic
effects,
causing
burst
ROS
simultaneously
promoting
cell
apoptosis
via
provoking
immunogenic
death.
The
high‐performance
effects
based
on
synergistic
effect
aforementioned
multiple
damage
ablation,
are
validated
TNBC
animal
models,
declaring
its
potential
safe
effective
anti‐tumor
agent.
proposed
approach
offers
new
perspectives
precise
efficient
treatment
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(4)
Опубликована: Янв. 26, 2024
This
review
is
aiming
to
systematically
elucidate
the
unique
role
of
nanotechnology
in
optimizing
therapeutic
modalities
for
combinatorial
cancer
immunotherapy,
which
enables
synergistic
integration
multiple
treatment
strategies.
In
particular,
has
enabled
combination
immunotherapy
with
physical
therapies,
chemotherapy,
metal
therapy,
and
nucleic
acid
therapy.
each
regimen,
nanocarriers
play
multifaceted
roles
by
achieving
targeted
codelivery
different
therapeutics
individual
modality.
offers
new
paradigms
guide
precision
medicine
treatment.
Immunotherapy
alone
unlikely
achieve
personalized
cancer,
are
needed
future.
To
overcome
technical
bottlenecks
realize
precise
regulation
tumor
microenvironment
treatment,
it
crucial
develop
novel
nanosystems
integrated
sensing,
targeting,
functionalities.
