Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 291 - 339
Опубликована: Ноя. 8, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 291 - 339
Опубликована: Ноя. 8, 2024
Язык: Английский
Turkish Journal of Physical Medicine and Rehabilitation, Год журнала: 2022, Номер 68(2), С. 262 - 270
Опубликована: Июнь 1, 2022
Objectives: This study aims to reveal the relationship between serum total antioxidant status (TAS), clinical parameters, and nutrition (dietary capacity [TAC]) in patients with fibromyalgia. Patients methods: cross-sectional was conducted a of 60 female participants (mean age: 44.7±9.7 years; range, 18 50 years) at Gaziler Physical Medicine Rehabilitation Hospital July 2020 February 2021. Thirty fibromyalgia were compared 30 age-, sex-, body mass index-matched healthy individuals. The short-form McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire (FIQ), Pittsburg Sleep Quality Index used. Total status, oxidant (TOS), oxidative stress index (OSI) measured. Dietary TAC calculated using ferric reducing ability plasma according food frequency questionnaire. Results: showed no significant difference groups (p=0.080). OSI significantly higher patient group (p<0.001 p=0.005, respectively). mean dietary 16.5±6.5 17.2±6.2 control group, it similar (p=0.492). global score than (p<0.001). moderate positive correlation TAS both (r=0.373, p=0.042 for r=0.380, p=0.038 group). In TOS FIQ scores (r=0.420, p=0.021 r=0.450, p=0.013, polyunsaturated fatty acid omega-6 intake lower (p=0.025 both). from vegetables (p=0.025), legumes/nuts (p=0.049), meat (p<0.001) lower, whereas cereal potatoes (p=0.028). Conclusion: results indicate that can be reduced by increasing
Язык: Английский
Процитировано
7ACS Medicinal Chemistry Letters, Год журнала: 2024, Номер 15(4), С. 510 - 517
Опубликована: Март 29, 2024
The peptidase neurolysin (Nln) has been validated as a potential target for developing therapeutics ischemic stroke (IS). Overexpression of Nln in mouse model IS provides significant cerebroprotection, leading to reduced infarction size and edema volume. Pharmacological inhibition the post-stroke brain worsens neurological outcomes. A virtual screen identified dipeptide small-molecule activators Nln. Optimization studies resulted class peptidomimetic compounds with promising activity. However, these still possessed an amide bond that compromised their stability plasma brain. Herein, we report synthesis characterization series bioisosteres based on our leads. Imidazole-based afford scaffolds increased potency activate combined enhanced significantly better permeability over original hits.
Язык: Английский
Процитировано
1Vitamins and hormones, Год журнала: 2024, Номер unknown, С. 241 - 287
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1Pharmaceutical Research, Год журнала: 2023, Номер 40(11), С. 2747 - 2758
Опубликована: Окт. 13, 2023
Язык: Английский
Процитировано
3Expert Opinion on Therapeutic Targets, Год журнала: 2022, Номер 26(5), С. 401 - 404
Опубликована: Май 4, 2022
KEYWORDS: allosteric enhancerallosteric activatordrug-discoverycerebroprotective therapymulti-targetstroke neuroprotectionenzyme activatorpeptidase activator
Язык: Английский
Процитировано
5Neuropeptides, Год журнала: 2022, Номер 95, С. 102265 - 102265
Опубликована: Июнь 7, 2022
Язык: Английский
Процитировано
3Nano Research, Год журнала: 2022, Номер 16(2), С. 2695 - 2705
Опубликована: Сен. 14, 2022
Язык: Английский
Процитировано
3AJP Cell Physiology, Год журнала: 2024, Номер 327(1), С. C151 - C167
Опубликована: Май 27, 2024
Substance P (SP) is released from sensory nerves in the arteries and heart. It activates neurokinin-1 receptors (NK1Rs) causing vasodilation, immune modulation, adverse cardiac remodeling. The hypothesis was tested: SP metabolites activate different second messenger signaling pathways. Macrophages, endothelial cells, fibroblasts metabolized to N- C-terminal varying extents. 5-11 most abundant metabolite followed by 1-4, 7-11, 6-11, 3-11, 8-11. In NK1R-expressing human embryonic kidney 293 (HEK293) some stimulate NK1R, promoting dissociation of several Gα proteins, including Gαs Gαq their βγ subunits. increases intracellular calcium concentrations ([Ca]
Язык: Английский
Процитировано
0Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 423 - 438
Опубликована: Ноя. 8, 2024
Процитировано
0Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 291 - 339
Опубликована: Ноя. 8, 2024
Язык: Английский
Процитировано
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