The relationship between dietary total antioxidant capacity, clinical parameters, and oxidative stress in fibromyalgia syndrome: A novel point of view

Turkish Journal of Physical Medicine and Rehabilitation, Journal Year: 2022, Volume and Issue: 68(2), P. 262 - 270

Published: June 1, 2022

Objectives: This study aims to reveal the relationship between serum total antioxidant status (TAS), clinical parameters, and nutrition (dietary capacity [TAC]) in patients with fibromyalgia. Patients methods: cross-sectional was conducted a of 60 female participants (mean age: 44.7±9.7 years; range, 18 50 years) at Gaziler Physical Medicine Rehabilitation Hospital July 2020 February 2021. Thirty fibromyalgia were compared 30 age-, sex-, body mass index-matched healthy individuals. The short-form McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire (FIQ), Pittsburg Sleep Quality Index used. Total status, oxidant (TOS), oxidative stress index (OSI) measured. Dietary TAC calculated using ferric reducing ability plasma according food frequency questionnaire. Results: showed no significant difference groups (p=0.080). OSI significantly higher patient group (p<0.001 p=0.005, respectively). mean dietary 16.5±6.5 17.2±6.2 control group, it similar (p=0.492). global score than (p<0.001). moderate positive correlation TAS both (r=0.373, p=0.042 for r=0.380, p=0.038 group). In TOS FIQ scores (r=0.420, p=0.021 r=0.450, p=0.013, polyunsaturated fatty acid omega-6 intake lower (p=0.025 both). from vegetables (p=0.025), legumes/nuts (p=0.049), meat (p<0.001) lower, whereas cereal potatoes (p=0.028). Conclusion: results indicate that can be reduced by increasing

Language: Английский

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Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability

ACS Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(4), P. 510 - 517

Published: March 29, 2024

The peptidase neurolysin (Nln) has been validated as a potential target for developing therapeutics ischemic stroke (IS). Overexpression of Nln in mouse model IS provides significant cerebroprotection, leading to reduced infarction size and edema volume. Pharmacological inhibition the post-stroke brain worsens neurological outcomes. A virtual screen identified dipeptide small-molecule activators Nln. Optimization studies resulted class peptidomimetic compounds with promising activity. However, these still possessed an amide bond that compromised their stability plasma brain. Herein, we report synthesis characterization series bioisosteres based on our leads. Imidazole-based afford scaffolds increased potency activate combined enhanced significantly better permeability over original hits.

Language: Английский

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A circadian clock regulates the blood-brain barrier across phylogeny

Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 241 - 287

Published: Jan. 1, 2024

Language: Английский

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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals

Pharmaceutical Research, Journal Year: 2023, Volume and Issue: 40(11), P. 2747 - 2758

Published: Oct. 13, 2023

Language: Английский

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Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy

Expert Opinion on Therapeutic Targets, Journal Year: 2022, Volume and Issue: 26(5), P. 401 - 404

Published: May 4, 2022

KEYWORDS: allosteric enhancerallosteric activatordrug-discoverycerebroprotective therapymulti-targetstroke neuroprotectionenzyme activatorpeptidase activator

Language: Английский

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Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence

Neuropeptides, Journal Year: 2022, Volume and Issue: 95, P. 102265 - 102265

Published: June 7, 2022

Language: Английский

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SC79 promotes efficient entry of GDNF liposomes into brain parenchyma to repair dopamine neurons through reversible regulation of tight junction proteins

Nano Research, Journal Year: 2022, Volume and Issue: 16(2), P. 2695 - 2705

Published: Sept. 14, 2022

Language: Английский

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Cellular Metabolism of Substance P Produces Neurokinin-1 Receptor Peptide Agonists with diminished cyclic AMP Signaling

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(1), P. C151 - C167

Published: May 27, 2024

Substance P (SP) is released from sensory nerves in the arteries and heart. It activates neurokinin-1 receptors (NK1Rs) causing vasodilation, immune modulation, adverse cardiac remodeling. The hypothesis was tested: SP metabolites activate different second messenger signaling pathways. Macrophages, endothelial cells, fibroblasts metabolized to N- C-terminal varying extents. 5-11 most abundant metabolite followed by 1-4, 7-11, 6-11, 3-11, 8-11. In NK1R-expressing human embryonic kidney 293 (HEK293) some stimulate NK1R, promoting dissociation of several Gα proteins, including Gαs Gαq their βγ subunits. increases intracellular calcium concentrations ([Ca]

Language: Английский

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Substance P in neurotrauma

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 423 - 438

Published: Nov. 8, 2024

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Substance P in inflammation

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 291 - 339

Published: Nov. 8, 2024

Language: Английский

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