The global prevalence of oral leukoplakia: a systematic review and meta-analysis from 1996 to 2022 DOI Creative Commons
Chang Zhang, Bingjie Li,

Xiamei Zeng

и другие.

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Сен. 6, 2023

Abstract Background Oral leukoplakia(OLK) is a common oral potentially malignant disorder. The global prevalence of solely OLK was published in 2003, while the varied among different studies. In recent years, large-scale summary and definition-related analyses obtain insufficient attention. This study aimed to perform systematic review studies leukoplakia assess predisposing factors its occurrence. Methods search terms ("Oral leukoplakia" OR leukoplakia) AND (prevalence incidence epidemiology) were searched databases (Pubmed, Embase, Scopus, Web Science) for from January 1996 until December 2022. estimated calculation risk bias analysis used STATA 16.0. Results We obtained 69 studies, including 1,263,028 participants, 28 countries, 6 continents. 1.39%, varying 0.12 33.33%. overall pooled 2.23% population-based 1.36% clinic-based population 9.10% specific populations. continents ranged 0.33 11.74% with statistical difference calculation. higher males than females. Those who smoked consumed alcohol had those did not. Conclusion Combining data determined as 1.39% pooling 3.41%. relatively consistent stable across definitions. A found males, aged over 60 years old, smokers, consumers. results included this revealed that various definitions continents, which may help developing treatment prevention strategies leukoplakia.

Язык: Английский

An Evidence-Based Update on the Potential for Malignancy of Oral Lichen Planus and Related Conditions: A Systematic Review and Meta-Analysis DOI Open Access
Miguel Ángel González‐Moles, Pablo Ramos‐García

Cancers, Год журнала: 2024, Номер 16(3), С. 608 - 608

Опубликована: Янв. 31, 2024

A systematic review and a meta-analysis is presented on published articles the malignant transformation of oral lichen planus (OLP) related conditions, which, based current evidence, updates an earlier by our research group that included publications until November 2018. In this updated study (Nov-2023) we searched MEDLINE, Embase, Web Science, Scopus. We evaluated methodological quality studies (QUIPS tool) carried out meta-analyses. The inclusion criteria were met 101 (38,083 patients), 20 new primary-level (11,512 patients) in last 5 years added to study. pooled ratio was 1.43% (95% CI = 1.09-1.80) for OLP; 1.38% 0.16-3.38) lichenoid lesions; 1.20% 0.00-4.25) reactions; 5.13% 1.90-9.43) OLP with dysplasia. No significant differences found between OLL or LR groups subgroup (

Язык: Английский

Процитировано

19
Toluidine Blue and Chlorin-e6 Mediated Photodynamic Therapy in the Treatment of Oral Potentially Malignant Disorders: A Systematic Review DOI Open Access

Anna Kruczek-Kazibudzka,

Barbara Lipka,

Jakub Fiegler-Rudol

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2528 - 2528

Опубликована: Март 12, 2025

Oral potentially malignant disorders (OPMDs) are conditions that carry an increased risk of transformation, including oral leukoplakia and lichen planus. Current management approaches differ based on each condition’s unique etiology pathophysiology, but all available treatment methods have notable limitations. This has prompted continued efforts to identify more effective therapeutic options. Photodynamic therapy (PDT) emerged as a minimally invasive yet potent alternative for treating OPMDs. systematic review examines the efficacy PDT mediated by toluidine blue chlorin-e6 (Photolon) in managing Following PRISMA guidelines, eight relevant studies published between 2010 2024 were included. Data study design, protocols, light parameters, photosensitizer characteristics collected evaluate outcomes. The reviewed evidence suggests toluidine-blue- chlorin-e6-mediated holds promise modality OPMDs, especially planus leukoplakia. Studies indicate its potential or adjunct therapy, particularly symptomatic refractory However, discrepancies designs coupled with limited number trials, impeded direct comparisons. Toluidine-blue- shows significant option Nonetheless, further investigations—including large-scale randomized controlled standardized exploration additional OPMDs beyond leukoplakia—are necessary order fully establish clinical utility facilitate widespread adoption.

Язык: Английский

Процитировано

2
Fusobacterium nucleatum and oral cancer: a critical review DOI Creative Commons

Emily McIlvanna,

Gerard J. Linden, Stephanie G. Craig

и другие.

BMC Cancer, Год журнала: 2021, Номер 21(1)

Опубликована: Ноя. 13, 2021

Abstract There is a growing level of interest in the potential role inflammation has on initiation and progression malignancy. Notable examples include Helicobacter pylori -mediated gastric cancer more recently Fusobacterium nucleatum colorectal cancer. Gram-negative anaerobic bacterium that was first isolated from oral cavity identified as periodontal pathogen. Biofilms squamous cell carcinomas are enriched with pathogens, including F. nucleatum, which prompted hypotheses this could contribute to development. Recent studies have demonstrated can promote by several mechanisms; activation proliferation, promotion cellular invasion, induction chronic immune evasion. This review provides an update association between carcinogenesis, insights into possible mechanisms underlying it.

Язык: Английский

Процитировано

95
Role of Artificial Intelligence in the Early Diagnosis of Oral Cancer. A Scoping Review DOI Open Access
María García-Pola, Eduardo Pons-Fuster, Carlota Suárez-Fernández

и другие.

Cancers, Год журнала: 2021, Номер 13(18), С. 4600 - 4600

Опубликована: Сен. 14, 2021

The early diagnosis of cancer can facilitate subsequent clinical patient management. Artificial intelligence (AI) has been found to be promising for improving the diagnostic process. aim present study is increase evidence on application AI oral through a scoping review. A search was performed in PubMed, Web Science, Embase and Google Scholar databases during period from January 2000 December 2020, referring non-invasive based applied screening. Only accessible full-text articles were considered. Thirty-six studies included detection images (photographs (optical imaging enhancement technology) cytology) with models. These characterized by their heterogeneous nature. Each publication involved different algorithm potential training data bias few comparative interpretation. may play an important role precisely predicting development cancer, though several methodological issues need addressed parallel advances techniques, order allow large-scale transfer latter population-based protocols.

Язык: Английский

Процитировано

86
An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review DOI
Miguel Ángel González‐Moles, Pablo Ramos‐García, Saman Warnakulasuriya

и другие.

Oral Diseases, Год журнала: 2020, Номер 27(8), С. 1908 - 1918

Опубликована: Дек. 4, 2020

Abstract Objectives We present a critical review of the papers published in international scientific literature on malignant transformation oral lichen planus (OLP). Our aim is to report most realistic estimate proportion OLP cases with based highest quality evidence. Materials and Methods Following search, we selected 89 that were this topic until November 2020. applied these an adaptation methodological criteria QUIPS tool ordered all them according their quality. The upper quartile (10 papers) analyzed. Results pooled (expressed as percentage) reported high was 2.28% (95% confidence intervals = 1.49–3.20). Conclusions observe malignancy higher research carried out under strict criteria. In review, propose for conducting follow‐up studies standards.

Язык: Английский

Процитировано

83
Management of oral potentially malignant disorders DOI
Alexander Ross Kerr, Giovanni Lodi

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 2008 - 2025

Опубликована: Июль 29, 2021

Patients with oral potentially malignant disorders (OPMDs), including leukoplakia and erythroplakia, proliferative verrucous leukoplakia, submucous fibrosis, lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development determining a patient's risk is key making management decisions. Yet, our understanding of the natural history OPMDs has not been fully elucidated, precision approach based on integration numerous predictive markers validated by prospective studies. Evidence-based health promotion clinicians healthcare systems embraced universally. Medical surgical interventions evaluated rigorous research measuring important endpoints, such as development, mortality, or survival, are difficult expensive run. Most these studies employ non-ideal surrogate endpoints have deep methodologic flaws. Diagnostic criteria for enrolling subjects uniform, patients highest comprise proportions those enrolled. Few explore quality life patient preferences. It time rethink how we patients, across each OPMD, considering infrastructure cost-effectiveness. Global networks well-characterized populations well-designed interventional trials using outcome measures needed.

Язык: Английский

Процитировано

77
Oral cancer development in lichen planus and related conditions—3.0 evidence level: A systematic review of systematic reviews DOI
Pablo Ramos‐García, Miguel Ángel González‐Moles, Saman Warnakulasuriya

и другие.

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1919 - 1935

Опубликована: Фев. 22, 2021

A systematic review of reviews-aka overview reviews, a novel type study design providing tertiary level evidence-is presented on reviews (SR) and meta-analyses (MTA) evaluating the cancer development in oral lichen planus (OLP), lichenoid lesions (OLL), reactions (OLR). We searched for SR-MTA published before January 2021. evaluated methodological quality using AMSTAR2 checked evidence. Inclusion criteria were met by seven SR-MTA. Oral ratios ranged between 0.44% 2.28% OLP, 1.88% 3.80% OLL, 1.71% OLR. Significant factors reported presence epithelial dysplasia, consumption tobacco alcohol, infection hepatitis C virus, atrophic erosive lesions, location tongue. Only, one SRs assessed evidence, most them judged to be critically low quality. In conclusion, based evidence incidence our results reaffirm classifying OLP as an potentially malignant disorder. relation OLLs OLRs, larger studies are necessary provide further scientific this regard. Future follow-up related should carried out under stricter that improve their

Язык: Английский

Процитировано

73
Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis DOI
Omar Kujan, Fernanda Weber Mello, Saman Warnakulasuriya

и другие.

Oral Diseases, Год журнала: 2020, Номер 27(8), С. 1936 - 1946

Опубликована: Ноя. 18, 2020

This systematic review and meta-analysis aimed to determine the proportion of patients who develop oral carcinomas following a diagnosis submucous fibrosis (OSF) in reported longitudinal studies. We also evaluate demographic clinicopathological factors contributing progression OSF cancer.Individual search strategies were applied for bibliographic databases: MEDLINE by PubMed, Scopus, Embase, Web Science, Grey literature databases until August 30, 2020. Methodological assessment risk bias included studies was undertaken using modified Newcastle-Ottawa scale. Meta-analyses conducted random-effects (DerSimonian Liard) method calculate pooled malignant transformation (MT) patients.Out 585 records screened, total 9 observational with number 6,337 patients; these, 292 cases developed carcinomas. The MT 4.2% (95% CI: 2.7%-5.6%) an annual rate 0.73%. Subgroup analysis revealed that significantly higher among population-based comparison hospital-based ones (p < .005). Most showed high bias. In several studies, there lack information about characteristics associated indicators; this insufficiency details hindered ability conduct further subgroup analyses.Despite poorly limited our confirms close 4% diagnosed may cancer. Cases epithelial dysplasia had potential transformation.

Язык: Английский

Процитировано

70
Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis DOI
Pablo Ramos‐García, Miguel Ángel González‐Moles, Fernanda Weber Mello

и другие.

Oral Diseases, Год журнала: 2021, Номер 27(8), С. 1896 - 1907

Опубликована: Май 19, 2021

Abstract Objectives To investigate the available evidence on malignant transformation (MT) of oral proliferative verrucous leukoplakia (PVL). Material and Methods We searched six main electronic three grey literature databases in a two‐phase process. Cohort studies investigating MT PVL were eligible for inclusion. The risk bias (RoB) was assessed using specific tool developed by Joanna Briggs Institute. Proportion meta‐analyses performed random‐effects model. Results Study selection resulted inclusion 17 studies. pooled proportion 43.87% (95% CI = 31.93–56.13). Females (64.02%, 95% 54.87–72.75) more affected than males (35.98%, 27.25–45.13). Gingiva (39.6%) buccal mucosa (21.6%) most frequent sites. No conclusive results found between sex or age distribution, tobacco, alcohol consumption. common site (39.9%), histopathological subtype conventional squamous cell carcinoma (62.1%). Four classified as low, nine moderate, four high RoB. Conclusion 43.87%. Among OPMDs, has highest to transform malignancy. Development agreement diagnostic criteria would reduce heterogeneity among future

Язык: Английский

Процитировано

60
Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis DOI Creative Commons

Teresa De Porras‐Carrique,

Miguel Ángel González‐Moles, Saman Warnakulasuriya

и другие.

Clinical Oral Investigations, Год журнала: 2021, Номер 26(2), С. 1391 - 1408

Опубликована: Авг. 30, 2021

Abstract Objectives We present this systematic review and meta-analyses to evaluate current evidence on the prevalence of depression, anxiety, stress in patients with oral lichen planus their magnitude association. Material methods searched PubMed, Embase, Web Science, Scopus, PsycInfo, Google Scholar for studies published before January 2021. evaluated quality using a specific method reviews addressing questions, designed by Joanna Briggs Institute. carried out performed heterogeneity, subgroups, meta-regression, small-study effects analyses. Results Fifty-one (which recruited 6,815 patients) met inclusion criteria. Our results reveal high depression (31.19%), anxiety (54.76%), (41.10%) planus. Furthermore, OLP presented significantly higher relative frequency than control group without (OR = 6.15, 95% CI 2.73–13.89, p < 0.001), 3.51, 2.10–5.85, 3.64, 1.48–8.94, 0.005), showing large effect sizes. Subgroups showed relevance participation psychologists psychiatrists diagnosis OLP. Multivariable meta-regression analysis importance comorbidity depression-anxiety Conclusions meta-analysis show that suffer stress, being more frequent general population. Clinical In dental clinic, especially dentists should be aware achieve correct referral.

Язык: Английский

Процитировано

58