Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis
GeroScience,
Год журнала:
2024,
Номер
46(5), С. 5133 - 5169
Опубликована: Июнь 28, 2024
Язык: Английский
Genome-wide association studies on periodontitis: A systematic review
PLoS ONE,
Год журнала:
2024,
Номер
19(9), С. e0306983 - e0306983
Опубликована: Сен. 6, 2024
Objectives
This
study
aims
to
systematically
review
the
existing
literature
and
critically
appraise
evidence
of
genome-wide
association
studies
(GWAS)
on
periodontitis.
also
synthesise
findings
genetic
risk
variants
periodontitis
from
included
GWAS.
Methods
A
systematic
search
was
conducted
PubMed,
GWAS
Catalog,
MEDLINE,
GLOBAL
HEALTH
EMBASE
via
Ovid
for
Only
exploring
single-nucleotide
polymorphisms(SNPs)
associated
with
were
eligible
inclusion.
The
quality
assessed
using
Q-genie
tool.
Information
such
as
population,
ethnicity,
genomic
data
source,
phenotypic
characteristics(definition
periodontitis),
methods(quality
control,
analysis
stages)
extracted.
SNPs
that
reached
conventional
or
suggestive
significance
level(5e-8
5e-06)
extracted
synthesized.
Results
total
15
good-quality
(Q-genie
scores
ranged
38–50).
There
huge
heterogeneities
among
studies.
11
identified
(rs242016,
rs242014,
rs10491972,
rs242002,
rs2978951,
rs2738058,
rs4284742,
rs729876,
rs149133391,
rs1537415,
rs12461706)
at
significant
level
(
p<5x10
-8
),
41
-6
but
no
common
found
between
Three
(rs4284742
[G],
rs11084095
[A],
rs12461706
[T])
three
large
same
gene
region–SIGLEC5.
Conclusion
showed
high
heterogeneity
methodology
used
provided
limited
statistics,
making
identifying
reliable
challenging.
clear
guidance
in
dental
research
requirement
expectation
make
statistics
available
other
investigators
are
needed.
Язык: Английский
Association between periodontal disease and age-related cognitive impairment: a narrative review
BMC Oral Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 14, 2025
Previous
studies
have
shown
associations
between
periodontal
disease
and
age-related
cognitive
impairment.
However,
little
is
known
about
the
different
functions
that
may
be
affected
in
patients
with
disease.
We
reviewed
recent
literature
to
better
understand
bidirectional
relationship
function
disease,
explore
assessments
useful
when
investigating
this
relationship.
also
around
improving
health
older
adults
presenting
impairment,
which
improve
their
cognition.
There
a
found
visuospatial
function,
attention,
memory,
language
are
important
domains
impaired
people
possibly
because
these
factors
associated
ability
adequately
brush
one's
teeth.
Furthermore,
we
noted
choice
of
assessment
particularly
studying
relation
health.
To
partner-assisted
interventions,
adequate
toothbrushing,
use
powered
toothbrush
all
been
proposed.
The
early
initiation
regular
oral
care
visits,
education
for
individuals,
cooking
skills,
dietary/caloric
restrictions
contribute
nature
improvements
help
appropriate
will
preserving
Язык: Английский
Oral Diseases Are Associated with Cognitive Decline and Dementia
Advances in experimental medicine and biology,
Год журнала:
2025,
Номер
unknown, С. 171 - 183
Опубликована: Янв. 1, 2025
Язык: Английский
“Chew on This: Oral Health is associated with Cognitive function among Canadians enrolled in the Canadian Longitudinal Study on Aging ”
Journal of Dentistry,
Год журнала:
2025,
Номер
unknown, С. 105720 - 105720
Опубликована: Апрель 1, 2025
Life
expectancy
has
increased
globally,
leading
to
a
higher
proportion
of
older
adults,
particularly
in
developed
countries
like
Canada.
This
demographic
shift
strains
healthcare
systems
and
is
associated
with
an
risk
dementia,
condition
characterised
by
cognitive
decline.
Oral
health
emerged
as
potential
modifiable
factor
for
yet
the
evidence
remains
conflicting.
study
examines
association
between
oral
parameters
functioning
Canadian
population,
utilizing
data
from
Longitudinal
Study
on
Aging
(CLSA).
A
cross-sectional
analysis
was
conducted
using
baseline
comprehensive
cohort
CLSA,
comprising
30,097
participants
aged
45-85
years.
assessed
via
self-reported
(SROH)
masticatory
ability
(MA).
Cognitive
function
evaluated
battery
neuropsychological
tests,
Impairment
Indicator
(CII)
derived.
Logistic
regression
models
were
employed
examine
impairment,
adjusting
confounders.
We
found
that
poor
SROH
not
significantly
impairment
(OR
=
1.19,
95%
CI
0.63-2.09),
while
inadequate
MA
odds
2.82,
1.82-4.25).
The
findings
suggest
significant
perceived
within
this
population.
These
results
chew
could
be
potentially
Further
research
warranted
explore
mechanisms
underlying
these
associations
develop
targeted
preventive
strategies.
paper
highlights
middle
elderly
Canadians
have
2.82
times
experiencing
impairment.
Addressing
chewing
difficulties
may
serve
early
decline,
offering
window
opportunity
slow
down
process
decline
among
aging
populations.
Язык: Английский
Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune–Neuroinflammation Mechanism
Brain Sciences,
Год журнала:
2023,
Номер
14(1), С. 41 - 41
Опубликована: Дек. 31, 2023
One
of
the
major
obstacles
confronting
formulation
a
mechanistic
understanding
for
Alzheimer’s
disease
(AD)
is
its
immense
complexity—a
complexity
that
traverses
full
structural
and
phenomenological
spectrum,
including
molecular,
macromolecular,
cellular,
neurological
behavioural
processes.
This
reflected
by
equally
complex
diversity
risk
factors
associated
with
AD.
However,
more
than
merely
mirroring
complexity,
also
provide
fundamental
insights
into
aetiology
pathogenesis
AD
as
neurodegenerative
disorder
since
they
are
central
to
initiation
subsequent
propagation.
Based
on
systematic
literature
assessment,
this
review
identified
30
then
extended
analysis
further
identify
neuroinflammation
unifying
mechanism
present
in
all
factors.
Although
other
mechanisms
(e.g.,
vasculopathy,
proteopathy)
were
multiple
factors,
dysfunction
neuroimmune–neuroinflammation
axis
was
uniquely
Though
nature
neuroinflammatory
involvement
varied,
activation
microglia
release
pro-inflammatory
cytokines
common
pathway
shared
observation
provides
evidence
importance
immunopathic
aetiopathogenesis
Язык: Английский
A rural teledentistry care experience: a geriatric approach to assessing oral health status and treatment needs in older adults from a Mapuche community in Chile
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 5, 2024
Background
Limited
attention
has
been
given
to
oral
health
challenges
faced
by
older
Indigenous
populations,
especially
in
rural
settings,
where
disparities
exist.
This
study
aims
assess
a
Mapuche
community
southern
Chile,
utilizing
geriatric
technology
support,
and
exploring
the
connection
between
well-being
fill
gap
this
context.
Methods
A
cross-sectional
was
conducted
involving
76
independent
adults
from
who
required
dental
care.
Assessments
were
remote
care
setting
gathering
extensive
data
including
comprehensive
assessments,
medical
conditions
using
teledentistry
platform
(TEGO
®
).
Statistical
analysis
involved
descriptive
analysis,
logistic
regression,
both
multiple
correspondence
k-means
cluster
analysis.
Results
The
sample
comprised
individuals
with
limited
formal
education
high
degree
of
vulnerability.
Geriatric
assessments
unveiled
cognitive
deterioration,
frailty,
depression
risk,
multimorbidity.
distribution
DMFT
index,
number
remaining
teeth,
occluding
pairs,
teeth
restorative
needs
other
relevant
clinical
findings
based
on
sociodemographic,
medical-geriatric-dental
characteristics,
additionally,
Multinomial
Logistic
Regression
Analysis
Dentition
Variables
Relation
performed.
burden
substantial,
an
average
index
25.96
(SD
4.38),
prevalence
non-functional
dentition
(89.3%),
periodontal
disease
(83%),
xerostomia
(63.2%)
mucosal
lesions
(31.5%).
Age,
lower
education,
depression,
daily
medication
sugary
consumption
frequency
associated
decreased
(
p
<
0.05).
Multiple
identified
4
clusters,
edentulous
functional
groups
being
most
distinct.
Conclusion
uncovers
substantial
intricate
medical-geriatric
interlinked
among
Chilean
community.
implementation
technological
ecosystem
enabled
resolution
less
complex
issues
facilitated
consultations
specialists,
reducing
necessity
for
travel
centers.
underscores
need
innovative
public
initiatives
address
improve
overall
adults.
Язык: Английский
Bibliometric analysis of the association between periodontal disease and cardiovascular disease
Huaxiang Jiang,
Fangqiang Liu,
Zishun Qin
и другие.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32065 - e32065
Опубликована: Май 31, 2024
Conduct
a
bibliometric
analysis
to
review
the
knowledge
structure
and
research
trends
regarding
association
between
periodontal
disease
cardiovascular
(CVD).
Язык: Английский
Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases
International Dental Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Evidence
suggests
an
association
between
periodontitis
and
neurodegenerative
diseases,
but
a
comprehensive
analysis
of
research
trends
remains
absent.
Therefore,
we
aim
to
identify
hotspots
on
the
comorbidity
understand
mechanisms,
provide
guidance
for
subsequent
studies
show
its
clinical
translational
possibility.
A
bibliometric
covering
1982
2023
was
conducted
using
Web
Science
Core
Collection.
English-language
articles
range
from
January
1,
November
30,
were
analyzed.
Data
downloaded
analyzed
December,
2023.
visualization
statistical
performed
annual
publications,
countries,
sources,
institutions,
authors,
most
cited
articles,
keywords
by
Microsoft
Excel,
VOSviewer,
Citespace,
R-bibliometrix
Origin
Pro.
total
1,238
diseases
identified.
Annual
publications
showed
upward
trend.
The
United
States,
University
College
London,
BRAIN
Shy,
Michael
E.
leading
nation,
affiliation,
source
author,
respectively.
NEUROLOGY,
Curtis
Maurice
A.
source,
author.
Keywords
network
highlighted
'Charcot-Marie-Tooth
Disease',
'Alzheimer's
Disease'
'Periodontitis'
as
focal
points.
Detection
citation
bursts
demonstrated
'Porphyromonas
gingivalis'
'Cognitive
Dysfunction'
hot
topics
in
recent
research.
In
years,
emerging
interests
(NDs)
are
growing.
Our
study
enhances
understanding
NDs
provides
valuable
perspectives
within
this
expanding
field,
offering
new
insights
into
regarding
interplay
Dysfunction'.
Further
molecular
mechanisms
P.
gingivalis-induced
periodontitis,
neuroinflammation,
that
leads
neurodegeneration
clearly
warranted.
Язык: Английский
Thirty Risk Factors for Alzheimer’s Disease Unified by a
Common Neuroimmune-Neuroinflammation Mechanism
Опубликована: Дек. 6, 2023
One
of
the
major
obstacles
confronting
formulation
a
mechanistic
understanding
for
Alzheimer’s
disease
(AD)
is
its
immense
complexity
–
that
traverses
full
structural
and
phenomenological
spectrum,
including
molecular,
macromolecular,
cellular,
neurological
behavioural
processes.
This
reflected
by
equally
complex
diversity
risk
factors
associated
with
AD.
However,
more
than
merely
mirroring
complexity,
also
provide
fundamental
insights
into
aetiology
pathogenesis
AD
as
neurodegenerative
disorder
since
they
are
central
to
initiation
subsequent
propagation.
Based
on
systematic
literature
assessment,
this
review
has
identified
30
then
extended
analysis
further
identify
neuroinflammation
unifying
mechanism
present
in
all
factors.
Although
other
mechanisms
(e.g.
vasculopathy)
were
multiple
factors,
dysfunction
neuroimmune-neuroinflammation
axis
was
uniquely
Though
nature
neuroinflammatory
involvement
varied,
activation
microglia
release
pro-inflammatory
cytokines
common
pathway
shared
observation
provides
evidence
importance
immunopathic
aetiopathogenesis
Язык: Английский