Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune-Neuroinflammation Mechanism DOI Open Access
Donald F. Weaver

Опубликована: Дек. 6, 2023

One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity – that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review has identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g. vasculopathy) were multiple factors, dysfunction neuroimmune-neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis

Язык: Английский

Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis DOI
Vittorio Dibello, Carlo Custodero, Raffaele Cavalcanti

и другие.

GeroScience, Год журнала: 2024, Номер 46(5), С. 5133 - 5169

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

11

Genome-wide association studies on periodontitis: A systematic review DOI Creative Commons
Chenyi Gao, Mark M. Iles, Harriet Larvin

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(9), С. e0306983 - e0306983

Опубликована: Сен. 6, 2024

Objectives This study aims to systematically review the existing literature and critically appraise evidence of genome-wide association studies (GWAS) on periodontitis. also synthesise findings genetic risk variants periodontitis from included GWAS. Methods A systematic search was conducted PubMed, GWAS Catalog, MEDLINE, GLOBAL HEALTH EMBASE via Ovid for Only exploring single-nucleotide polymorphisms(SNPs) associated with were eligible inclusion. The quality assessed using Q-genie tool. Information such as population, ethnicity, genomic data source, phenotypic characteristics(definition periodontitis), methods(quality control, analysis stages) extracted. SNPs that reached conventional or suggestive significance level(5e-8 5e-06) extracted synthesized. Results total 15 good-quality (Q-genie scores ranged 38–50). There huge heterogeneities among studies. 11 identified (rs242016, rs242014, rs10491972, rs242002, rs2978951, rs2738058, rs4284742, rs729876, rs149133391, rs1537415, rs12461706) at significant level ( p<5x10 -8 ), 41 -6 but no common found between Three (rs4284742 [G], rs11084095 [A], rs12461706 [T]) three large same gene region–SIGLEC5. Conclusion showed high heterogeneity methodology used provided limited statistics, making identifying reliable challenging. clear guidance in dental research requirement expectation make statistics available other investigators are needed.

Язык: Английский

Процитировано

4

Association between periodontal disease and age-related cognitive impairment: a narrative review DOI Creative Commons
Naoki Saji, Kenji Matsushita, Akinori Takeda

и другие.

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 14, 2025

Previous studies have shown associations between periodontal disease and age-related cognitive impairment. However, little is known about the different functions that may be affected in patients with disease. We reviewed recent literature to better understand bidirectional relationship function disease, explore assessments useful when investigating this relationship. also around improving health older adults presenting impairment, which improve their cognition. There a found visuospatial function, attention, memory, language are important domains impaired people possibly because these factors associated ability adequately brush one's teeth. Furthermore, we noted choice of assessment particularly studying relation health. To partner-assisted interventions, adequate toothbrushing, use powered toothbrush all been proposed. The early initiation regular oral care visits, education for individuals, cooking skills, dietary/caloric restrictions contribute nature improvements help appropriate will preserving

Язык: Английский

Процитировано

0

Oral Diseases Are Associated with Cognitive Decline and Dementia DOI
Chenyi Gao, Jing Kang

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown, С. 171 - 183

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

“Chew on This: Oral Health is associated with Cognitive function among Canadians enrolled in the Canadian Longitudinal Study on Aging ” DOI Creative Commons
Praveen Bhoopathi Haricharan,

J.S. Feine,

Lamin Juwara

и другие.

Journal of Dentistry, Год журнала: 2025, Номер unknown, С. 105720 - 105720

Опубликована: Апрель 1, 2025

Life expectancy has increased globally, leading to a higher proportion of older adults, particularly in developed countries like Canada. This demographic shift strains healthcare systems and is associated with an risk dementia, condition characterised by cognitive decline. Oral health emerged as potential modifiable factor for yet the evidence remains conflicting. study examines association between oral parameters functioning Canadian population, utilizing data from Longitudinal Study on Aging (CLSA). A cross-sectional analysis was conducted using baseline comprehensive cohort CLSA, comprising 30,097 participants aged 45-85 years. assessed via self-reported (SROH) masticatory ability (MA). Cognitive function evaluated battery neuropsychological tests, Impairment Indicator (CII) derived. Logistic regression models were employed examine impairment, adjusting confounders. We found that poor SROH not significantly impairment (OR = 1.19, 95% CI 0.63-2.09), while inadequate MA odds 2.82, 1.82-4.25). The findings suggest significant perceived within this population. These results chew could be potentially Further research warranted explore mechanisms underlying these associations develop targeted preventive strategies. paper highlights middle elderly Canadians have 2.82 times experiencing impairment. Addressing chewing difficulties may serve early decline, offering window opportunity slow down process decline among aging populations.

Язык: Английский

Процитировано

0

Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune–Neuroinflammation Mechanism DOI Creative Commons
Donald F. Weaver

Brain Sciences, Год журнала: 2023, Номер 14(1), С. 41 - 41

Опубликована: Дек. 31, 2023

One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity—a complexity that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g., vasculopathy, proteopathy) were multiple factors, dysfunction neuroimmune–neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis

Язык: Английский

Процитировано

7

A rural teledentistry care experience: a geriatric approach to assessing oral health status and treatment needs in older adults from a Mapuche community in Chile DOI Creative Commons
Víctor Beltrán,

Fernanda Muñoz-Sepúlveda,

Cláudia Rosa Acevedo

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Июнь 5, 2024

Background Limited attention has been given to oral health challenges faced by older Indigenous populations, especially in rural settings, where disparities exist. This study aims assess a Mapuche community southern Chile, utilizing geriatric technology support, and exploring the connection between well-being fill gap this context. Methods A cross-sectional was conducted involving 76 independent adults from who required dental care. Assessments were remote care setting gathering extensive data including comprehensive assessments, medical conditions using teledentistry platform (TEGO ® ). Statistical analysis involved descriptive analysis, logistic regression, both multiple correspondence k-means cluster analysis. Results The sample comprised individuals with limited formal education high degree of vulnerability. Geriatric assessments unveiled cognitive deterioration, frailty, depression risk, multimorbidity. distribution DMFT index, number remaining teeth, occluding pairs, teeth restorative needs other relevant clinical findings based on sociodemographic, medical-geriatric-dental characteristics, additionally, Multinomial Logistic Regression Analysis Dentition Variables Relation performed. burden substantial, an average index 25.96 (SD 4.38), prevalence non-functional dentition (89.3%), periodontal disease (83%), xerostomia (63.2%) mucosal lesions (31.5%). Age, lower education, depression, daily medication sugary consumption frequency associated decreased ( p &lt; 0.05). Multiple identified 4 clusters, edentulous functional groups being most distinct. Conclusion uncovers substantial intricate medical-geriatric interlinked among Chilean community. implementation technological ecosystem enabled resolution less complex issues facilitated consultations specialists, reducing necessity for travel centers. underscores need innovative public initiatives address improve overall adults.

Язык: Английский

Процитировано

2

Bibliometric analysis of the association between periodontal disease and cardiovascular disease DOI Creative Commons

Huaxiang Jiang,

Fangqiang Liu,

Zishun Qin

и другие.

Heliyon, Год журнала: 2024, Номер 10(11), С. e32065 - e32065

Опубликована: Май 31, 2024

Conduct a bibliometric analysis to review the knowledge structure and research trends regarding association between periodontal disease cardiovascular (CVD).

Язык: Английский

Процитировано

1

Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases DOI Creative Commons
Jiale Han, Yihan Liu,

Xiaoyang Guo

и другие.

International Dental Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Evidence suggests an association between periodontitis and neurodegenerative diseases, but a comprehensive analysis of research trends remains absent. Therefore, we aim to identify hotspots on the comorbidity understand mechanisms, provide guidance for subsequent studies show its clinical translational possibility. A bibliometric covering 1982 2023 was conducted using Web Science Core Collection. English-language articles range from January 1, November 30, were analyzed. Data downloaded analyzed December, 2023. visualization statistical performed annual publications, countries, sources, institutions, authors, most cited articles, keywords by Microsoft Excel, VOSviewer, Citespace, R-bibliometrix Origin Pro. total 1,238 diseases identified. Annual publications showed upward trend. The United States, University College London, BRAIN Shy, Michael E. leading nation, affiliation, source author, respectively. NEUROLOGY, Curtis Maurice A. source, author. Keywords network highlighted 'Charcot-Marie-Tooth Disease', 'Alzheimer's Disease' 'Periodontitis' as focal points. Detection citation bursts demonstrated 'Porphyromonas gingivalis' 'Cognitive Dysfunction' hot topics in recent research. In years, emerging interests (NDs) are growing. Our study enhances understanding NDs provides valuable perspectives within this expanding field, offering new insights into regarding interplay Dysfunction'. Further molecular mechanisms P. gingivalis-induced periodontitis, neuroinflammation, that leads neurodegeneration clearly warranted.

Язык: Английский

Процитировано

1

Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune-Neuroinflammation Mechanism DOI Open Access
Donald F. Weaver

Опубликована: Дек. 6, 2023

One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity – that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review has identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g. vasculopathy) were multiple factors, dysfunction neuroimmune-neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis

Язык: Английский

Процитировано

1