Cardiovascular risk emerges earlier by birth weight and preterm birth status in the United States add health sample

International Journal of Cardiology, Год журнала: 2025, Номер unknown, С. 132994 - 132994

Опубликована: Янв. 1, 2025

Язык: Английский

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Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies

PLoS Medicine, Год журнала: 2023, Номер 20(1), С. e1004036 - e1004036

Опубликована: Янв. 26, 2023

Background Preterm birth is the leading cause of perinatal morbidity and mortality associated with adverse developmental long-term health outcomes, including several cardiometabolic risk factors outcomes. However, evidence about association preterm later body size derives mainly from studies using weight as a proxy prematurity rather than an actual length gestation. We investigated gestational age (GA) at infancy through adolescence. Methods findings conducted two-stage individual participant data (IPD) meta-analysis 253,810 mother–child dyads 16 general population-based cohort in Europe (Denmark, Finland, France, Italy, Norway, Portugal, Spain, Netherlands, United Kingdom), North America (Canada), Australasia (Australia) to estimate GA mass index (BMI) overweight (including obesity) adjusted for following maternal characteristics potential confounders: education, height, prepregnancy BMI, ethnic background, parity, smoking during pregnancy, child’s birth, diabetes hypertension, preeclampsia. Pregnancy LifeCycle EUCAN-Connect projects were invited eligible inclusion if they had information on minimum one measurement BMI between Using federated analytical tool (DataSHIELD), we fitted linear logistic regression models each separately complete-case approach combined estimates standard errors random-effects study-level providing overall effect early (>0.0 0.5 years), late (>0.5 2.0 childhood (>2.0 5.0 mid-childhood (>5.0 9.0 (>9.0 14.0 adolescence (>14.0 19.0 years). was positively first decade life, greatest increase mean z-score (0.02, 95% confidence interval (CI): 0.00; 0.05, p < 0.05) per week GA, while adolescence, individuals reached similar levels (0.00, CI: −0.01; 0.01, 0.9) term counterparts. The revealed pattern odds ratio (OR) (OR 1.01 1.02) GA. By however, slightly negatively 0.98 [95% 0.97; 1.00], 0.1) Although based only four cohorts ( n = 32,089) that suggest born very may be increased 1.46 1.03; 2.08], compared Findings consistent across sensitivity analyses despite considerable heterogeneity characteristics. residual confounding limitation this study, less generalisable settings low- middle-income countries. Conclusions This study found important infancy, but strength attenuates consistently age. have average peers term.

Язык: Английский

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A lifetime perspective on risk factors for cognitive decline with a special focus on early events

Cerebral Circulation - Cognition and Behavior, Год журнала: 2024, Номер 6, С. 100217 - 100217

Опубликована: Янв. 1, 2024

Both Alzheimer's disease and vascular dementia are the result of processes that typically develop over several decades. Population studies have estimated more than half risk for is preventable or at least modifiable through behavioral adaptations. The association between these lifestyle factors most evident exposure in midlife. However, habits formed middle age often reflect a lifetime behavior patterns living conditions. Therefore, individuals who, example, able to maintain healthy diets regular exercise during their years likely benefit from cognition-protective they practiced throughout lives. For numerous adult diseases, significant risks can be traced back early childhood. Suboptimal conditions perinatal period, childhood adolescence increase including stroke, heart disease, insulin resistance, hypertension dementia. This review aims summarizing some evidence life-time perspective with goal raising awareness prevention successful aging.

Язык: Английский

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The association between late preterm birth and cardiometabolic conditions across the life course: A systematic review and meta‐analysis

Paediatric and Perinatal Epidemiology, Год журнала: 2021, Номер 36(2), С. 264 - 275

Опубликована: Ноя. 22, 2021

Abstract Background The effect of being born late preterm (34–36 weeks gestation) on cardiometabolic outcomes across the life course is unclear. Objectives To systematically review association between (spontaneous or indicated), compared to term and in children adults. Data sources EMBASE(Ovid), MEDLINE(Ovid), CINAHL. Study selection data extraction Observational studies up July 2021 were included. characteristics, gestational age, outcomes, risk ratios (RRs), odds (ORs), hazard (HRs), mean differences 95% confidence intervals (CIs) extracted. Synthesis We pooled converted RRs using random‐effects meta‐analyses for diabetes, hypertension, ischemic heart disease (IHD) body mass index (BMI) with subgroups bias was assessed Newcastle‐Ottawa scale certainty evidence grading recommendations, assessment, development evaluation (GRADE) approach. Results Forty‐one included (41,203,468 total participants; median: 5.0% preterm). Late birth associated increased diabetes (RR 1.24, CI 1.17, 1.32; nine studies; n = 6,056,511; incidence 0.9%; I 2 51%; low certainty) hypertension 1.21, 1.13, 1.30; 11 3,983,141; 3.4%; 64%; adults combined. decreased BMI z ‐scores (standard difference −0.38; −0.67, −0.09; five 32,602; proportion 8.3%; 96%; very certainty). There insufficient that IHD (HR 1.20, 0.89, 1.62; four 2,706,806; 0.3%; 87%; Conclusions an hypertension. low. Inconsistencies definitions, confounding variables outcome age limited comparability studies.

Язык: Английский

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Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Children, Год журнала: 2022, Номер 9(12), С. 1843 - 1843

Опубликована: Ноя. 28, 2022

Advances in perinatal and neonatal care have led to improved survival of preterm infants into adulthood. However, the shift focus long-term health adults born requires a clear understanding impact prematurity on developing organ systems development adult-oriented disease. A less well-recognized area risk for surviving is their cardiometabolic health. Epidemiologic evidence has linked birth systemic hypertension, type 2 diabetes, metabolic syndrome, heart failure, ischemic Of more significant concern that disorders higher compared full-term infants. The interconnected nature cardio-pulmonary system means worsening morbidity mortality preterm. Addressing problems holistically would help promote cardiovascular health, wellness, quality life over lifetime. Recognizing are unique subset population challenge current healthcare environment. issues relevant clinically research domain, using technology characterize cardiopulmonary physiology exercise tolerance, screening tools early diagnosis treatment, robust follow-up these with access longitudinal data improve both longevity

Язык: Английский

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Association of Late Preterm Birth and Size for Gestational Age With Cardiometabolic Risk in Childhood

JAMA Network Open, Год журнала: 2022, Номер 5(5), С. e2214379 - e2214379

Опубликована: Май 27, 2022

Importance

The long-term cardiometabolic consequences of late preterm birth (34-36 weeks' gestation) are not well understood.

Objective

To assess whether and size for gestational age associated with risk (CMR) in childhood.

Design, Setting, Participants

This retrospective cohort study included 1742 children born Ontario, Canada, between April 1, 2006, September 30, 2014, followed up until 2019. Data from enrolled Applied Research Group Kids (TARGet Kids!) primary care practice–based research network were linked to administrative health data at ICES (formerly known as the Institute Clinical Evaluative Sciences). Participants excluded if they had conditions affecting growth (eg, failure thrive or cystic fibrosis), any acute chronic (other than asthma high-functioning autism), severe developmental delay, families who unable communicate English.

Exposures

Late birth, a continuous measure, age.

Main Outcomes Measures

outcome was composite CMR score (overall age- sex-standardizedzscore components, including waist circumference, log triglyceride level, glucose systolic blood pressure, high-density lipoprotein cholesterol level). Secondary outcomes individual components. Multivariable linear regression analysis used separately evaluate associations age, ages 3 12 years.

Results

Among 2440 eligible children, (mean [SD] 5.6 [2.2] years; 951 boys [54.6%]) final cohort. Overall, 87 (5.0%) moderately (<34 gestation), 145 (8.3%) 455 (26.1%) early term (37-38 1055 (60.6%) full (≥39 gestation). Compared term, those (adjusted β = 0.50; 95% CI, 0.24-0.75) 0.27; 0.06-0.47) higher scores. Each additional week 0.06 U β; –0.08 –0.03 U) decrease CMR.

Conclusions Relevance

In this study, These results suggest that screening early-life interventions these may prevent outcomes.

Язык: Английский

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Maintaining an active lifestyle from adolescence to adulthood might alleviate the adverse association of preterm birth with cardiometabolic health

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(2), С. 102966 - 102966

Опубликована: Фев. 1, 2024

We aimed to determine whether physical activity attenuates preterm birth's adverse effects on adult cardiometabolic health.

Язык: Английский

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Growth and body composition of infants born moderate-to-late preterm fed a protein- and mineral-enriched postdischarge formula compared with a standard term formula until 6 months corrected age, a randomized controlled trial

American Journal of Clinical Nutrition, Год журнала: 2024, Номер 120(1), С. 111 - 120

Опубликована: Май 6, 2024

Infants born moderate-to-late preterm (i.e., 32 0/7–35 6/7 weeks' gestation) are, analogous to those very preterm, at risk of later obesity, hypertension, and diabetes. Appropriate early life nutrition is key for ensuring optimal growth body composition, thereby mitigating potential cardiometabolic risks. To compare composition between infants fed isocaloric but protein- mineral-enriched postdischarge formula (PDF) or standard term (STF) until 6 months corrected age (CA; i.e., after equivalent [TEA]). After enrolment (≤7 days postpartum), received PDF if (fortified) mother's own milk (MOM) was insufficient. At TEA, receiving >25% intake as were randomized either continue the same (n=47) switch STF (n=50); ≥75% MOM (n=60) served references. TEA CA, we assessed anthropometry using both dual-energy x-ray absorptiometry air displacement plethysmography. Feeding groups had similar gestational (median [p25;p75]: 34.3 [33.5;35.1] weeks), birthweight (mean ± SD: 2175 412 g), TEA. slightly, significantly, higher length (67.6 2.5 66.9 2.6 cm, p<0.05) larger head circumference (43.9 1.3 43.4 1.5 compared STF. Also, lean mass bone mineral content estimated by (4772 675 4502 741 g; 140 20 131 23 g, respectively; p<0.05). Air plethysmography estimates, however, not statistically different feeding groups. demonstrated modest increases in length, circumference, mass, when International Clinical Trial Registry Platform (https://trialsearch.who.int) as: NTR5117 (old-NTR) NTR NL4979 (new-NTR) .

Язык: Английский

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Integrating genetics, metabolites, and clinical characteristics in predicting cardiometabolic health outcomes using machine learning algorithms – A systematic review

Computers in Biology and Medicine, Год журнала: 2025, Номер 186, С. 109661 - 109661

Опубликована: Янв. 11, 2025

Machine learning (ML) integration of clinical, metabolite, and genetic data reveals variable results in predicting cardiometabolic health (CMH) outcomes. Therefore, we aim to (1) evaluate whether a multi-modal approach incorporating all three types using ML algorithms can improve CMH outcome prediction compared single-modal or paired-modal models, (2) compare the methodologies used existing models. We systematically searched five databases from 1998 2024 for predictive modelling studies Risk-of-bias assessment tools were assess methodological quality. Study characteristics, algorithms, preprocessing, evaluation methods metrics, feature selections, importance parameters synthesized narratively show heterogeneity. Of four included (3 algorithms), at low risk bias, one was high risk. The consistently improved T2D BP Genetics showed lowest performance studies. Logistic regression (n = 2 studies) random forest 1) studies, while XGBoost study. One study with missing variations selection across hindered comprehensive comparison importance. Our review emphasizes potential improvement approach. However, further diverse optimized on single-modal, paired-modal, models are needed gain insights into biomarker

Язык: Английский

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The growth diversity of preterm infants at 0–36 months corrected age in China: a real-world observational study

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Янв. 31, 2025

Premature delivery interrupts the natural growth of fetus. The postnatal healthy management preterm infants still follows term standards after a postmenstrual age (PMA) 40 weeks and there is lack research on longitudinal dynamic tracks infants. Based database established by Wuhan University Internet+ Early Childhood Development Alliance in China, information infants, including birth registration health follow-ups from 2016 to 2022, was incorporated into system. Standardized anthropometric measurements were recorded corrected (CA) 36 months. A generalized additive model based location, scale, shape used establish percentile values curves. In total, 79,514 included this study, weights at each gestational (GA) similar Chinese standards. When evaluated weight, we found that proportions extrauterine retardation PMA all above 10% GA ≤34-week groups reached between 17.19% 55.56% very (VPIs). There high incidence with weight below third VPIs when referring CAs 0, 6, 12, 24, months (p < 0.001). We curves population different GAs 0 months, which indicated weight/length late close while trajectory consistently lagged behind Our study revealed trajectories GAs. set for established, offering an optional method assessment special population.

Язык: Английский

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