Dentistry Journal, Год журнала: 2022, Номер 10(10), С. 195 - 195
Опубликована: Окт. 20, 2022
Based on the 2018 classification of periodontal disease, a series articles have been published describing decision points therapy and how findings collected at those can be used as guidelines for therapy. The are reviewed with focus finding inadequate calculus removal that impacts treatment outcomes.
Язык: Английский
Periodontology 2000, Год журнала: 2022, Номер 89(1), С. 9 - 18
Опубликована: Март 4, 2022
Abstract Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus, is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment periodontitis reduces systemic inflammation surrogate markers comorbid diseases. The potential cause‐and‐effect connection between comorbidities corroborated preclinical models disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances our understanding periodontitis‐systemic connection, may potentially lead to innovative therapeutic options reduce risk periodontitis‐linked comorbidities.
Язык: Английский
Процитировано
249
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Авг. 14, 2023
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial contributing to defense. Their biological functions in innate immunity, as well their structure activity relationships, along with mechanisms action therapeutic potential, have been great interest recent years. To highlight the key research into role human animal health, we first describe history, structural features, evolution, antimicrobial mechanisms. Next, cover immune homeostasis, chemotaxis, mucosal barrier function, gut microbiota regulation, intestinal development regulation cell death. Further, discuss clinical relevance potential various diseases, including infectious disease, inflammatory bowel diabetes obesity, chronic lung periodontitis cancer. Finally, summarize current knowledge regarding nutrient-dependent defensins, fatty acids, amino microelements, plant extracts, probiotics, while considering application such regulation. Together, review summarizes functions, mechanism actions significance challenges developing defensins-based therapy, thus providing crucial insights biology utility.
Язык: Английский
Процитировано
92
Periodontology 2000, Год журнала: 2024, Номер 96(1), С. 7 - 19
Опубликована: Окт. 1, 2024
Abstract For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in oral cavity. Initially, associations with multitude noncommunicable diseases were each studied separately, and relationships shown. The morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory have demonstrated. As most studies cross‐sectional nature, questions about causality cannot univocally answered. And an independent risk factor for one systemic disease, becomes even more difficult assess since recently also associated multimorbidity. Periodontitis many share environmental, lifestyle genetic factors, immunopathology. Moreover, suffering from common may increase susceptibility another chronic disease; effects condition various factors disease. overarching effect any is it causing pro‐inflammatory state individual; this shown periodontitis. prothrombotic elevated immunological activity such, when we consider can affect progression other importantly, vice versa. this, not surprising that variety diseases. medical definition includes different organs systems. Thus, aim opinion paper propose should its own right affects individual's wellbeing. dental profession researchers alike, adapt paradigm shift, advancing out isolated anatomical location into total being some conditions comorbid and, versa, comorbidities initiation
Язык: Английский
Процитировано
22
Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13
Опубликована: Фев. 27, 2023
Periodontitis and inflammatory bowel diseases (IBD) are of the gastrointestinal tract that share common features microbial-induced ecological dysregulation host immune response. The close relationship between periodontitis IBD is characterized by a higher prevalence in patients with severity IBD, indicating different from traditional independent form an “Oral-Gut” axis two, which affect each other thus vicious circle. However, specific mechanisms leading to association two not fully understood. In this article, we describe interconnection terms microbial pathogenesis dysregulation, including ectopic colonization gut pathogenic bacteria associated promotes inflammation activating response, alteration oral microbiota due affects periodontal Among factors, such as Klebsiella , Porphyromonas gingivalis Fusobacterium nucleatum may act bridge while among mechanisms, Th17 cell responses secreted pro-inflammatory factors IL-1β, IL-6 TNF-α play key role development both diseases. This suggests future studies, can look for targets control intervene regulating or intestinal flora through immunological methods.
Язык: Английский
Процитировано
31
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2023, Номер 1870(7), С. 119521 - 119521
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
30
Clinical Oral Investigations, Год журнала: 2024, Номер 28(2)
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
17
Journal of Periodontal Research, Год журнала: 2024, Номер 59(3), С. 491 - 499
Опубликована: Янв. 9, 2024
Abstract Background and Objective Previous studies suggest interaction between periodontitis thyroid function, while the causality has not yet been established. We applied Mendelian randomization (MR) method to assess bidirectional causal association thyroid‐related traits, including free thyroxine (FT4), stimulating hormone (TSH), hypothyroidism, hyperthyroidism autoimmune disease (AITD). Methods Genetic instruments were extracted from large‐scale genome‐wide on normal‐range FT4 ( N = 49 269) TSH 54 288) levels, in full range 119 715); hypothyroidism (discovery/replication cohorts: 53 423/334 316), 51 823/257 552), AITD 755 406) 45 563). Here, inverse variance weighted (IVW) was as primary analysis, robustness of results assessed by several pleiotropic‐robust methods. Results adjusted for Bonferroni correction thresholds with significant p < .004 (0.05/13) suggestive .05. The IVW analysis revealed a suggestively linkage genetic predisposition increased risk (discovery cohort: odds ratio [OR] 1.24, 95% confidence interval [CI] 1.05–1.46, .012; replication OR 1.06, CI 1.01–1.11, .011). No evidence found supporting impact risks (associated ≥ .209), well traits .105). These findings robust consistent through sensitivity other MR models. Conclusion This reveals should be attributed variations function but it potential effect risk, which provides better understanding relationship clinical intervention hypothyroidism. Further investigations are warranted elucidate nature underlying mechanisms this finding.
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 655 - 655
Опубликована: Май 17, 2024
In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target agents. context, re-synthesized three sets of bases, 5a–f, 6a–f, and 7a–f, evaluate their biological applications. The data from in vitro assays (including antioxidant scavenging activities, anti-diabetes, anti-Alzheimer’s, anti-inflammatory properties) the 7a–f showed that six 5a, 5d, 5e, 5f, 7a, 7f possess highest properties among compounds evaluated. cytotoxicity against lung (A549) colon (Caco-2) human cancer types, well normal (WI-38) cell lines, was investigation demonstrated 7a are active cells, while two 5e exhibited towards cells. Additionally, enzymatic activities caspase-3 Bcl-2 were Furthermore, assessed silico absorption, distribution, metabolism, toxicity (ADMT) more potent bases. After modifying structures plan further extend studies future.
Язык: Английский
Процитировано
10
Current Opinion in Virology, Год журнала: 2022, Номер 55, С. 101248 - 101248
Опубликована: Июль 20, 2022
Язык: Английский
Процитировано
35
BMC Oral Health, Год журнала: 2023, Номер 23(1)
Опубликована: Июль 15, 2023
Abstract Background Periodontitis is a common and chronic inflammatory disease characterized by irreversible destruction of the tooth surrounding tissues, especially intrabony defects, which eventually lead to loss. In recent years, stem cell-based therapy for periodontitis has been gradually applied clinic, but whether plays positive role in periodontal regeneration unclear at present. Methods The clinical studies related evaluation mesenchymal cells PubMed, Cochrane Central Register Controlled trials (CENTRAL), Web Science (WOS), Embase, Scopus, Wanfang China national knowledge infrastructure (CNKI) databases were searched June 2023. inclusion criteria required compare efficacy with cell free treatment periodontitis, have follow-up least six months. Two evaluators searched, screened, assessed quality risk bias included independently. Review Manager 5.4 software was used perform meta-analysis, GRADEpro GDT evaluate level evidence. Results Five randomized controlled (RCTs) including 118 patients analyzed. results this meta-analysis demonstrated that showed better therapeutic effects on attachment (CAL) (MD = − 1.18, 95% CI 1.55, 0.80, P < 0.00001), pocket probing depth (PPD) 0.75, 1.35, 0.14, 0.020), linear distance from bone crest bottom defect (BC-BD)( MD 0.95, 1.67, 0.23, 0.010) compared cell-free group. However, presented insignificant gingival recession (P 0.14), cementoenamel junction 0.05). Conclusion demonstrate may be beneficial CAL, PPD BC-BD. Due limited number included, strength analysis affected certain extent. high‐quality RCTs large sample size, multi-blind, multi-centric are still required, methodological normative study protocol should established executed future.
Язык: Английский
Процитировано
20