The role of viruses in oral mucosal lesions
Periodontology 2000,
Год журнала:
2024,
Номер
96(1), С. 189 - 202
Опубликована: Фев. 27, 2024
Abstract
The
mucosa
of
the
oral
cavity
is
exposed
to
a
large
number
different
microorganisms
such
as
archaea,
bacteria,
fungi,
parasites,
and
viruses.
Among
those,
viruses
cause
specific
infections,
which
can
easily
be
transmitted
from
one
person
another.
infectious
route
may
not
only
include
patients
their
relatives
but
also
dental
professional
team.
Thus,
wide
knowledge
regarding
viral
infections
crucial
for
daily
routine.
Signs
symptoms
completely
absent
or
develop
into
pronounced
clinical
picture,
so
that
early
detection
information
determine
further
course
infection
its
influence
on
other
inflammatory
diseases,
periodontitis,
well
safety
family
members
social
environment.
As
manifestation
highly
variable
leading
heterogenous
mucosal
lesions
it
is,
in
most
cases,
mandatory
differentiate
them
by
microbiological
tests
addition
examination
procedures.
This
article
will
give
an
overview
role
infecting
mucosa,
addition,
describe
management.
Язык: Английский
Prevalence of the Novel Recombinant LSDV in East and Southeast Asia: Inducing Skin and Testicular Damage in Golden Hamsters
Microbial Pathogenesis,
Год журнала:
2024,
Номер
197, С. 107057 - 107057
Опубликована: Окт. 22, 2024
Язык: Английский
Appraising the life‐course impact of Epstein‐Barr virus exposure and its genetic signature on periodontitis
Journal of Periodontology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Background
Periodontitis
arises
from
a
multifaceted
interplay
of
environmental
variables
and
genetic
susceptibility,
where
microbial
infection
plays
an
indispensable
part.
Epstein‐Barr
virus
(EBV)
exposure
has
long
been
considered
associated
with
periodontitis
activity;
however,
the
causal
relationship
connection
between
them
remain
unknown.
Methods
Within
life‐course
context,
our
study
employed
comprehensive
Mendelian
randomization
(MR)
methods,
including
univariable,
multivariable,
Bayesian
model
averaging,
reverse
MR,
to
investigate
association
EBV
periodontitis.
Additionally,
linkage
disequilibrium
score
regression
colocalization
analysis
were
utilized
assess
cross‐trait
correlations,
followed
by
transcriptome‐wide
enrichment
discern
genetic‐phenotypic
biological
profiles.
Results
Heightened
levels
antibodies,
particularly
early
antigen
diffuses
(which
serve
as
indicators
or
reactivation),
are
increased
risk
(odds
ratio
[OR]:
1.27
[1.09–1.47],
p
=
6.05
×
10
−3
)
demonstrate
significant
correlation
(
4.11
).
This
pathogenesis
may
involve
high‐confidence
gene
RNASEK
located
in
17p13.1.
Genetically
predicted
early‐life
anti‐EBV
immunoglobulin
G
(IgG)
correlated
reduced
(OR:
0.89
[0.82–0.97],
1.76
Conclusions
The
present
highlights
impact
its
hallmark
on
periodontitis,
providing
novel
perspectives
into
underlying
management
strategies
for
EBV‐related
These
findings
underscore
diverse
clinical
public
health
implications,
encompassing
antiviral
therapies,
viral
vaccination
strategies,
tailored
interventions
individualized
management.
Further
research
is
required
validate
expand
upon
findings.
Plain
Language
Summary
chronic
inflammatory
disease
driven
interactions
pathogens
host
immune
system.
While
bacteria
have
traditionally
focus
research,
recent
studies
highlight
significance
virus‐bacteria
interactions,
role
(EBV)—a
herpesvirus
infecting
over
90%
global
population—in
development
However,
mechanisms
unclear.
Our
genome‐wide
multi‐omics
approaches
link
We
found
that
reactivation
increases
whereas
exposure,
possibly
enabling
resistance,
reduce
it.
Essential
genes
identified
potential
mediators,
CRTC3‐AS1
,
HLA‐DQA1
.
provide
insights
EBV‐periodontitis
connection.
For
example,
testing
control
could
benefit
patients
unresponsive
standard
bacterial
treatments,
via
might
elucidate
these
contribution
interactions.
Язык: Английский
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis
Mucosal Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Biomaterial-based Drug Delivery Strategies for Oral Mucosa
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
251, С. 114604 - 114604
Опубликована: Март 5, 2025
Язык: Английский
Revealing the viral culprits: the hidden role of the oral virome in head and neck cancers
Archives of Microbiology,
Год журнала:
2025,
Номер
207(4)
Опубликована: Фев. 28, 2025
Abstract
The
oral
viral
microbiome
(or
virome),
encompassing
a
diverse
community
of
viruses
within
the
cavity,
has
emerged
as
significant
yet
underexplored
factor
in
head
and
neck
cancers
(HNCs).
This
review
synthesizes
recent
evidence
linking
virome
to
carcinogenesis,
particularly
oropharyngeal
nasopharyngeal
carcinomas—the
most
common
virus-associated
subtypes
HNCs.
Beyond
pathogenesis,
diagnostic
therapeutic
implications
are
explored,
including
non-invasive
salivary
detection
biomarkers
for
early
cancer
diagnosis,
development
targeted
antiviral
therapies,
preventive
vaccination
strategies—exemplified
by
success
HPV
vaccines
reducing
incidence
cancers.
Despite
these
advancements,
challenges
persist,
technical
limitations,
need
longitudinal
studies,
integration
multi-omics
approaches.
A
comprehensive
understanding
could
revolutionize
diagnostics,
therapeutics,
prevention.
Moving
forward,
collaborative
interdisciplinary
efforts
will
be
essential
fully
leverage
research
improving
HNC
outcomes.
Язык: Английский
The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1759 - 1759
Опубликована: Ноя. 11, 2024
Saliva
has
emerged
as
a
promising
diagnostic
fluid
for
viral
infections,
enabling
the
direct
analysis
of
genetic
material
and
detection
infection
markers
such
proteins,
metabolites,
microRNAs,
immunoglobulins.
This
comprehensive
review
aimed
to
explore
use
saliva
tool
emphasizing
its
advantages
limitations.
stands
out
due
simplicity
safety
in
collection,
along
with
convenience
self-collection
without
need
healthcare
supervision,
while
potentially
being
comparable
urine
blood
terms
effectiveness.
Herein,
we
highlighted
significant
potential
assessing
loads
diagnosing
herpesviruses,
HPV,
PyV,
TTV,
SARS-CoV-2,
MPXV.
The
shedding
underscores
utility
early
diagnosis,
monitoring
progression,
evaluating
treatment
responses.
non-invasive
nature
collection
makes
it
an
appealing
alternative
more
invasive
methods,
promoting
better
patient
compliance
facilitating
large-scale
screening
surveillance.
As
such,
further
highlight
current
evidence
on
prognostic
tool.
Although
amount
data
is
already
available,
investigations
are
warranted
comprehensively
assess
added
benefit
from
utilization
salivary
biomarkers
clinics.
Salivary
show
great
promise
prevention
complications,
improving
disease
management
control
at
population
level.
Integrating
these
tools
into
routine
clinical
practice
could
enhance
personalized
strategies
outcomes.
Future
studies
should
focus
establishing
standardization
protocols,
validating
accuracy
diagnostics,
expanding
research
capabilities
biomarkers.
Язык: Английский