The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections DOI Creative Commons
Nilson Ferreira, Rafael Antônio Velôso Caixeta, Rodrigo Melim Zerbinati

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1759 - 1759

Published: Nov. 11, 2024

Saliva has emerged as a promising diagnostic fluid for viral infections, enabling the direct analysis of genetic material and detection infection markers such proteins, metabolites, microRNAs, immunoglobulins. This comprehensive review aimed to explore use saliva tool emphasizing its advantages limitations. stands out due simplicity safety in collection, along with convenience self-collection without need healthcare supervision, while potentially being comparable urine blood terms effectiveness. Herein, we highlighted significant potential assessing loads diagnosing herpesviruses, HPV, PyV, TTV, SARS-CoV-2, MPXV. The shedding underscores utility early diagnosis, monitoring progression, evaluating treatment responses. non-invasive nature collection makes it an appealing alternative more invasive methods, promoting better patient compliance facilitating large-scale screening surveillance. As such, further highlight current evidence on prognostic tool. Although amount data is already available, investigations are warranted comprehensively assess added benefit from utilization salivary biomarkers clinics. Salivary show great promise prevention complications, improving disease management control at population level. Integrating these tools into routine clinical practice could enhance personalized strategies outcomes. Future studies should focus establishing standardization protocols, validating accuracy diagnostics, expanding research capabilities biomarkers.

Language: Английский

The role of viruses in oral mucosal lesions DOI
Henrik Dommisch,

Andrea Maria Schmidt‐Westhausen

Periodontology 2000, Journal Year: 2024, Volume and Issue: 96(1), P. 189 - 202

Published: Feb. 27, 2024

Abstract The mucosa of the oral cavity is exposed to a large number different microorganisms such as archaea, bacteria, fungi, parasites, and viruses. Among those, viruses cause specific infections, which can easily be transmitted from one person another. infectious route may not only include patients their relatives but also dental professional team. Thus, wide knowledge regarding viral infections crucial for daily routine. Signs symptoms completely absent or develop into pronounced clinical picture, so that early detection information determine further course infection its influence on other inflammatory diseases, periodontitis, well safety family members social environment. As manifestation highly variable leading heterogenous mucosal lesions it is, in most cases, mandatory differentiate them by microbiological tests addition examination procedures. This article will give an overview role infecting mucosa, addition, describe management.

Language: Английский

Citations

7
Biomaterial-based Drug Delivery Strategies for Oral Mucosa DOI
Junhui Liu,

Jiao Sun,

Jun Hu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114604 - 114604

Published: March 5, 2025

Language: Английский

Citations

0
Appraising the life‐course impact of Epstein‐Barr virus exposure and its genetic signature on periodontitis DOI
Xinjian Ye, Yuan Jian, Yijing Bai

et al.

Journal of Periodontology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Background Periodontitis arises from a multifaceted interplay of environmental variables and genetic susceptibility, where microbial infection plays an indispensable part. Epstein‐Barr virus (EBV) exposure has long been considered associated with periodontitis activity; however, the causal relationship connection between them remain unknown. Methods Within life‐course context, our study employed comprehensive Mendelian randomization (MR) methods, including univariable, multivariable, Bayesian model averaging, reverse MR, to investigate association EBV periodontitis. Additionally, linkage disequilibrium score regression colocalization analysis were utilized assess cross‐trait correlations, followed by transcriptome‐wide enrichment discern genetic‐phenotypic biological profiles. Results Heightened levels antibodies, particularly early antigen diffuses (which serve as indicators or reactivation), are increased risk (odds ratio [OR]: 1.27 [1.09–1.47], p = 6.05 × 10 −3 ) demonstrate significant correlation ( 4.11 ). This pathogenesis may involve high‐confidence gene RNASEK located in 17p13.1. Genetically predicted early‐life anti‐EBV immunoglobulin G (IgG) correlated reduced (OR: 0.89 [0.82–0.97], 1.76 Conclusions The present highlights impact its hallmark on periodontitis, providing novel perspectives into underlying management strategies for EBV‐related These findings underscore diverse clinical public health implications, encompassing antiviral therapies, viral vaccination strategies, tailored interventions individualized management. Further research is required validate expand upon findings. Plain Language Summary chronic inflammatory disease driven interactions pathogens host immune system. While bacteria have traditionally focus research, recent studies highlight significance virus‐bacteria interactions, role (EBV)—a herpesvirus infecting over 90% global population—in development However, mechanisms unclear. Our genome‐wide multi‐omics approaches link We found that reactivation increases whereas exposure, possibly enabling resistance, reduce it. Essential genes identified potential mediators, CRTC3‐AS1 , HLA‐DQA1 . provide insights EBV‐periodontitis connection. For example, testing control could benefit patients unresponsive standard bacterial treatments, via might elucidate these contribution interactions.

Language: Английский

Citations

3
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis DOI Creative Commons
Flávia Saavedra,

Danielle Barbosa Brotto,

Vineet Joag

et al.

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Revealing the viral culprits: the hidden role of the oral virome in head and neck cancers DOI Creative Commons
Abdelhakim Salem

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: Feb. 28, 2025

Abstract The oral viral microbiome (or virome), encompassing a diverse community of viruses within the cavity, has emerged as significant yet underexplored factor in head and neck cancers (HNCs). This review synthesizes recent evidence linking virome to carcinogenesis, particularly oropharyngeal nasopharyngeal carcinomas—the most common virus-associated subtypes HNCs. Beyond pathogenesis, diagnostic therapeutic implications are explored, including non-invasive salivary detection biomarkers for early cancer diagnosis, development targeted antiviral therapies, preventive vaccination strategies—exemplified by success HPV vaccines reducing incidence cancers. Despite these advancements, challenges persist, technical limitations, need longitudinal studies, integration multi-omics approaches. A comprehensive understanding could revolutionize diagnostics, therapeutics, prevention. Moving forward, collaborative interdisciplinary efforts will be essential fully leverage research improving HNC outcomes.

Language: Английский

Citations

0
Prevalence of the Novel Recombinant LSDV in East and Southeast Asia: Inducing Skin and Testicular Damage in Golden Hamsters DOI
Jingyu Wang,

Shaobing Wan,

Shizhe Liu

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 197, P. 107057 - 107057

Published: Oct. 22, 2024

Language: Английский

Citations

2
The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections DOI Creative Commons
Nilson Ferreira, Rafael Antônio Velôso Caixeta, Rodrigo Melim Zerbinati

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1759 - 1759

Published: Nov. 11, 2024

Saliva has emerged as a promising diagnostic fluid for viral infections, enabling the direct analysis of genetic material and detection infection markers such proteins, metabolites, microRNAs, immunoglobulins. This comprehensive review aimed to explore use saliva tool emphasizing its advantages limitations. stands out due simplicity safety in collection, along with convenience self-collection without need healthcare supervision, while potentially being comparable urine blood terms effectiveness. Herein, we highlighted significant potential assessing loads diagnosing herpesviruses, HPV, PyV, TTV, SARS-CoV-2, MPXV. The shedding underscores utility early diagnosis, monitoring progression, evaluating treatment responses. non-invasive nature collection makes it an appealing alternative more invasive methods, promoting better patient compliance facilitating large-scale screening surveillance. As such, further highlight current evidence on prognostic tool. Although amount data is already available, investigations are warranted comprehensively assess added benefit from utilization salivary biomarkers clinics. Salivary show great promise prevention complications, improving disease management control at population level. Integrating these tools into routine clinical practice could enhance personalized strategies outcomes. Future studies should focus establishing standardization protocols, validating accuracy diagnostics, expanding research capabilities biomarkers.

Language: Английский

Citations

1