Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Дек. 15, 2022
Infectious
diseases
caused
by
antibiotic-resistant
bacterial
(ARB)
pathogens
are
a
serious
threat
to
human
and
animal
health.
The
active
surveillance
of
ARB
using
an
integrated
one-health
approach
can
help
reduce
the
emergence
spread
ARB,
associated
economic
impact,
guide
antimicrobial
stewardship
programs.
Wastewater
(WWS)
provides
composite
samples
for
total
population,
with
easy
access
mixed
community
microbiome.
This
concept
is
emerging
rapidly,
but
clinical
utility,
sensitivity,
uniformity
WWS
remain
poorly
understood
especially
in
relation
evidence
sewershed
communities.
Here,
we
systematically
searched
literature
identify
studies
that
have
compared
findings
from
antibiotic
resistance
genes
(ARG)
parallel,
thereby
evaluating
how
likely
ARG
relate
cases
Initially,
2,235
articles
were
obtained
primary
search
keywords,
1,219
remained
after
de-duplication.
Among
these,
35
fulfilled
criteria,
additional
13
relevant
included
searching
references
literature.
48
papers,
34
used
culture-based
method,
followed
11
metagenomics,
three
PCR-based
methods.
A
28
out
conducted
at
single
level,
eight
involved
several
countries,
seven
national
or
regional
scales,
five
hospital
levels.
Our
review
revealed
performance
has
been
evaluated
more
frequently
Escherichia
coli,
Enterococcus
spp.,
other
members
family
Enterobacteriaceae
,
not
uniformly
tested
all
pathogens.
Many
wastewater-based
comparing
evaluate
public
health
risk
ARB.
Indeed,
relating
straightforward,
as
source
wastewater
cannot
be
only
symptomatic
individuals
also
asymptomatic
carriers
well
sources.
Further,
varying
fates
each
species
within
sewerage
make
aim
connecting
complicated.
Therefore,
future
many
AMR
their
one
process
simpler
interpretation
results
easier.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Март 23, 2022
Antibiotic
resistance
genes
(ARGs)
have
accelerated
microbial
threats
to
human
health
in
the
last
decade.
Many
can
confer
resistance,
but
evaluating
relative
risks
of
ARGs
is
complex.
Factors
such
as
abundance,
propensity
for
lateral
transmission
and
ability
be
expressed
pathogens
are
all
important.
Here,
an
analysis
at
metagenomic
level
from
various
habitats
(6
types
habitats,
4572
samples)
detects
2561
that
collectively
conferred
24
classes
antibiotics.
We
quantitatively
evaluate
risk
humans,
defined
will
confound
clinical
treatment
pathogens,
these
by
integrating
accessibility,
mobility,
pathogenicity
availability.
Our
results
demonstrate
23.78%
pose
a
risk,
especially
those
which
multidrug
resistance.
also
calculate
antibiotic
samples
four
main
with
machine
learning,
successfully
map
global
marine
over
75%
accuracy.
novel
method
surveilling
help
manage
one
most
important
animal
health.
Environment International,
Год журнала:
2020,
Номер
140, С. 105733 - 105733
Опубликована: Апрель 27, 2020
A
comprehensive
monitoring
of
a
broad
set
antibiotics
in
the
final
effluent
wastewater
treatment
plants
(WWTPs)
7
European
countries
(Portugal,
Spain,
Ireland,
Cyprus,
Germany,
Finland,
and
Norway)
was
carried
out
two
consecutive
years
(2015
2016).
This
is
first
study
this
kind
performed
at
an
international
level.
Within
53
monitored
17
were
detected
least
once
WWTPs,
i.e.:
ciprofloxacin,
ofloxacin,
enrofloxacin,
orbifloxacin,
azithromycin,
clarithromycin,
sulfapyridine,
sulfamethoxazole,
trimethoprim,
nalidixic
acid,
pipemidic
oxolinic
cefalexin,
clindamycin,
metronidazole,
ampicillin,
tetracycline.
The
exhibiting
highest
average
concentrations
Ireland
southern
Portugal
whereas
northern
(Norway,
Finland
Germany)
Cyprus
exhibited
lower
total
concentration.
antibiotic
occurrence
data
effluents
used
for
assessment
their
impact
on
aquatic
environment.
Both,
environmental
predicted
no
effect
concentration
(PNEC-ENVs)
PNECs
based
minimal
inhibitory
(PNEC-MICs)
considered
evaluation
microbial
communities
systems
evolution
resistance,
respectively.
Based
analysis,
three
compounds,
azithromycin
cefalexin
are
proposed
as
markers
pollution,
they
could
occasionally
pose
risk
to
Integrated
studies
like
crucial
map
pollution
provide
basis
designing
water
quality
regular
programs.
Abstract
Antibiotics
are
widely
used
in
animal
husbandry,
and
various
types
of
antibiotic
resistance
genes
(ARGs)
frequently
detected
livestock
waste
around
the
world.
Conventional
treatment
processes
do
not
completely
remove
ARGs,
resulting
their
release
to
soil
water
environments.
Various
exposure
routes
these
ARGs
humans,
including
inhalation
ingestion
antibiotic-resistant
bacteria
(ARB)
that
harbor
them,
may
be
contributing
rise
resistant
clinical
infections
increasingly
difficult
treat
with
antibiotics.
In
this
review,
we
assess
occurrence
variability
wastes
potential
propagation
pathways
human
pathogens.
We
also
review
mechanisms
environmental
factors
influence
dissemination
through
pathways,
evaluate
ARG
removal
efficiency
common
management
approaches.
Challenges
research
needs
for
assessing
mitigating
risk
from
presented.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2021,
Номер
11
Опубликована: Ноя. 25, 2021
Antibiotic
resistance
(ABR)
is
a
growing
public
health
concern
worldwide,
and
it
now
regarded
as
critical
One
Health
issue.
Health's
interconnected
domains
contribute
to
the
emergence,
evolution,
spread
of
antibiotic-resistant
microorganisms
on
local
global
scale,
which
significant
risk
factor
for
health.
The
persistence
resistant
microbial
species,
association
determinants
at
human-animal-environment
interface
can
alter
genomes,
resulting
in
superbugs
various
niches.
ABR
motivated
by
well-established
link
between
three
domains:
human,
animal,
environmental
As
result,
addressing
through
approach
makes
sense.
Several
countries
have
implemented
national
action
plans
based
combat
microbes,
following
Tripartite's
Commitment
Food
Agriculture
Organization
(FAO)-World
Animal
(OIE)-World
(WHO)
guidelines.
has
been
identified
concern,
efforts
are
being
made
mitigate
this
threat.
To
summarize,
interdisciplinary
unified
approaches
principles
required
limit
dissemination
cycle,
raise
awareness
education
about
antibiotic
use,
promote
policy,
advocacy,
antimicrobial
stewardship.
European Journal of Pharmacology,
Год журнала:
2019,
Номер
866, С. 172813 - 172813
Опубликована: Ноя. 18, 2019
The
environmental
occurrence
of
antimicrobial
pharmaceuticals
and
antibiotic
resistant
bacteria
genes
has
become
a
global
phenomenon
multifaceted
threat.
Integrated
actions
many
parties
are
needed
to
prevent
further
aggravation
the
problem.
Well-directed
require
clear
understanding
problem,
which
can
be
ensured
by
frequent
revaluation
existing
knowledge
disseminating
it
among
relevant
audiences.
goal
this
review
paper
is
discuss
abundance
in
aquatic
environment
context
adverse
effects
caused
directly
these
substances
threat
associated
with
antibiotics
resistance
phenomenon.
Several
classes
(aminoglycosides,
β-lactams,
glycopeptides,
macrolides,
fluoroquinolones,
sulfonamides
trimethoprim,
tetracyclines)
have
been
selected
illustrate
their
sources,
abundance,
degradation
routes
(transformation
products)
implications
including
ecotoxic
effect
spread
within
compartments
wastewater
treatment
plants.
Wastewater
plants
indeed
main
source
responsible
for
prevalence
factors
environment,
since
predominantly
not
designed
retain
pharmaceuticals.
In
order
limit
impurities
into
better
control
recommended
as
well
establishment
stricter
quality
standards.
Counteracting
all
above-mentioned
threats
requires
undertake
integrated
activities
based
on
cooperation
professionals
scientists
from
various
fields
science
or
industry,
such
sciences,
medicine,
veterinary,
pharmacology,
chemical
engineering
others.