Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review DOI Creative Commons
Ananda Tiwari, Paula Kurittu, Ahmad Ibrahim Al‐Mustapha

и другие.

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Дек. 15, 2022

Infectious diseases caused by antibiotic-resistant bacterial (ARB) pathogens are a serious threat to human and animal health. The active surveillance of ARB using an integrated one-health approach can help reduce the emergence spread ARB, associated economic impact, guide antimicrobial stewardship programs. Wastewater (WWS) provides composite samples for total population, with easy access mixed community microbiome. This concept is emerging rapidly, but clinical utility, sensitivity, uniformity WWS remain poorly understood especially in relation evidence sewershed communities. Here, we systematically searched literature identify studies that have compared findings from antibiotic resistance genes (ARG) parallel, thereby evaluating how likely ARG relate cases Initially, 2,235 articles were obtained primary search keywords, 1,219 remained after de-duplication. Among these, 35 fulfilled criteria, additional 13 relevant included searching references literature. 48 papers, 34 used culture-based method, followed 11 metagenomics, three PCR-based methods. A 28 out conducted at single level, eight involved several countries, seven national or regional scales, five hospital levels. Our review revealed performance has been evaluated more frequently Escherichia coli, Enterococcus spp., other members family Enterobacteriaceae , not uniformly tested all pathogens. Many wastewater-based comparing evaluate public health risk ARB. Indeed, relating straightforward, as source wastewater cannot be only symptomatic individuals also asymptomatic carriers well sources. Further, varying fates each species within sewerage make aim connecting complicated. Therefore, future many AMR their one process simpler interpretation results easier.

Язык: Английский

Antibiotic resistance in the environment DOI Open Access
D. G. Joakim Larsson, Carl‐Fredrik Flach

Nature Reviews Microbiology, Год журнала: 2021, Номер 20(5), С. 257 - 269

Опубликована: Ноя. 4, 2021

Язык: Английский

Процитировано

1795
A review of the global climate change impacts, adaptation, and sustainable mitigation measures DOI Open Access

Kashif Abbass,

Muhammad Qasim, Huaming Song

и другие.

Environmental Science and Pollution Research, Год журнала: 2022, Номер 29(28), С. 42539 - 42559

Опубликована: Апрель 4, 2022

Язык: Английский

Процитировано

1303
Defining and combating antibiotic resistance from One Health and Global Health perspectives DOI
Sara Hernando‐Amado, Teresa M. Coque, Fernando Baquero

и другие.

Nature Microbiology, Год журнала: 2019, Номер 4(9), С. 1432 - 1442

Опубликована: Авг. 22, 2019

Язык: Английский

Процитировано

927
Occurrence and fate of antibiotics, antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARB) in municipal wastewater treatment plant: An overview DOI
Jianlong Wang,

Libing Chu,

László Wojnárovits

и другие.

The Science of The Total Environment, Год журнала: 2020, Номер 744, С. 140997 - 140997

Опубликована: Июль 18, 2020

Язык: Английский

Процитировано

725
Assessment of global health risk of antibiotic resistance genes DOI Creative Commons
Zhenyan Zhang, Qi Zhang, Tingzhang Wang

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Март 23, 2022

Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many can confer resistance, but evaluating relative risks of ARGs is complex. Factors such as abundance, propensity for lateral transmission and ability be expressed pathogens are all important. Here, an analysis at metagenomic level from various habitats (6 types habitats, 4572 samples) detects 2561 that collectively conferred 24 classes antibiotics. We quantitatively evaluate risk humans, defined will confound clinical treatment pathogens, these by integrating accessibility, mobility, pathogenicity availability. Our results demonstrate 23.78% pose a risk, especially those which multidrug resistance. also calculate antibiotic samples four main with machine learning, successfully map global marine over 75% accuracy. novel method surveilling help manage one most important animal health.

Язык: Английский

Процитировано

548
Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment DOI Creative Commons
Sara Rodríguez‐Mozaz, Ivone Vaz‐Moreira,

Saulo Varela Della Giustina

и другие.

Environment International, Год журнала: 2020, Номер 140, С. 105733 - 105733

Опубликована: Апрель 27, 2020

A comprehensive monitoring of a broad set antibiotics in the final effluent wastewater treatment plants (WWTPs) 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out two consecutive years (2015 2016). This is first study this kind performed at an international level. Within 53 monitored 17 were detected least once WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole, trimethoprim, nalidixic acid, pipemidic oxolinic cefalexin, clindamycin, metronidazole, ampicillin, tetracycline. The exhibiting highest average concentrations Ireland southern Portugal whereas northern (Norway, Finland Germany) Cyprus exhibited lower total concentration. antibiotic occurrence data effluents used for assessment their impact on aquatic environment. Both, environmental predicted no effect concentration (PNEC-ENVs) PNECs based minimal inhibitory (PNEC-MICs) considered evaluation microbial communities systems evolution resistance, respectively. Based analysis, three compounds, azithromycin cefalexin are proposed as markers pollution, they could occasionally pose risk to Integrated studies like crucial map pollution provide basis designing water quality regular programs.

Язык: Английский

Процитировано

505
Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution DOI
João Botelho, Filipa Grosso,

Luı́sa Peixe

и другие.

Drug Resistance Updates, Год журнала: 2019, Номер 44, С. 100640 - 100640

Опубликована: Май 1, 2019

Язык: Английский

Процитировано

438
Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment DOI Creative Commons

Ya He,

Qingbin Yuan, Jacques Mathieu

и другие.

npj Clean Water, Год журнала: 2020, Номер 3(1)

Опубликована: Фев. 19, 2020

Abstract Antibiotics are widely used in animal husbandry, and various types of antibiotic resistance genes (ARGs) frequently detected livestock waste around the world. Conventional treatment processes do not completely remove ARGs, resulting their release to soil water environments. Various exposure routes these ARGs humans, including inhalation ingestion antibiotic-resistant bacteria (ARB) that harbor them, may be contributing rise resistant clinical infections increasingly difficult treat with antibiotics. In this review, we assess occurrence variability wastes potential propagation pathways human pathogens. We also review mechanisms environmental factors influence dissemination through pathways, evaluate ARG removal efficiency common management approaches. Challenges research needs for assessing mitigating risk from presented.

Язык: Английский

Процитировано

421
Antibiotic Resistance: One Health One World Outlook DOI Creative Commons
Bilal Aslam, Mohsin Khurshid, Muhammad Arshad

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Ноя. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Язык: Английский

Процитировано

393
Antimicrobial pharmaceuticals in the aquatic environment - occurrence and environmental implications DOI Creative Commons
Ewa Felis, Joanna Kalka, Adam Sochacki

и другие.

European Journal of Pharmacology, Год журнала: 2019, Номер 866, С. 172813 - 172813

Опубликована: Ноя. 18, 2019

The environmental occurrence of antimicrobial pharmaceuticals and antibiotic resistant bacteria genes has become a global phenomenon multifaceted threat. Integrated actions many parties are needed to prevent further aggravation the problem. Well-directed require clear understanding problem, which can be ensured by frequent revaluation existing knowledge disseminating it among relevant audiences. goal this review paper is discuss abundance in aquatic environment context adverse effects caused directly these substances threat associated with antibiotics resistance phenomenon. Several classes (aminoglycosides, β-lactams, glycopeptides, macrolides, fluoroquinolones, sulfonamides trimethoprim, tetracyclines) have been selected illustrate their sources, abundance, degradation routes (transformation products) implications including ecotoxic effect spread within compartments wastewater treatment plants. Wastewater plants indeed main source responsible for prevalence factors environment, since predominantly not designed retain pharmaceuticals. In order limit impurities into better control recommended as well establishment stricter quality standards. Counteracting all above-mentioned threats requires undertake integrated activities based on cooperation professionals scientists from various fields science or industry, such sciences, medicine, veterinary, pharmacology, chemical engineering others.

Язык: Английский

Процитировано

344