Somatostatin regulates central clock function and circadian responses to light DOI Creative Commons

Deborah A. M. Joye,

Kayla E. Rohr,

Kimberlee Suenkens

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(18)

Опубликована: Апрель 25, 2023

Daily and annual changes in light are processed by central clock circuits that control the timing of behavior physiology. The suprachiasmatic nucleus (SCN) anterior hypothalamus processes daily photic inputs encodes day length (i.e., photoperiod), but SCN regulate circadian photoperiodic responses to remain unclear. Somatostatin (SST) expression is modulated photoperiod, role SST has not been examined. Our results indicate signaling regulates rhythms function a manner influenced sex. First, we use cell-fate mapping provide evidence regulated via de novo Sst activation. Next, demonstrate -/- mice display enhanced light, with increased behavioral plasticity jetlag, constant conditions. Notably, lack eliminated sex differences due males, suggesting interacts process differently each also displayed an increase number retinorecipient neurons core, which express type receptor capable resetting molecular clock. Last, show modulates influencing encoding, network after-effects, intercellular synchrony sex-specific manner. Collectively, these insight into peptide mechanisms its response light.

Язык: Английский

Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior DOI Creative Commons
Alessandra Porcu, Anna Nilsson,

Sathwik Booreddy

и другие.

Science Advances, Год журнала: 2022, Номер 8(35)

Опубликована: Сен. 2, 2022

Seasonal changes in day length (photoperiod) affect numerous physiological functions. The suprachiasmatic nucleus (SCN)–paraventricular (PVN) axis plays a key role processing photoperiod-related information. variations SCN and PVN neurotransmitter expression have been observed humans animal models. However, the molecular mechanisms by which SCN-PVN network responds to altered photoperiod is unknown. Here, we show mice that neuromedin S (NMS) vasoactive intestinal polypeptide (VIP) neurons display photoperiod-induced plasticity. In vivo recording of calcium dynamics revealed NMS alter activity response winter-like photoperiod. Chronic manipulation sufficient induce switching affects locomotor activity. Our findings reveal previously unidentified adaptations seasonality for adjusting hypothalamic function via coordinated multisynaptic affecting behavior.

Язык: Английский

Процитировано

36
Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus DOI Creative Commons
Daisuke Ono, Huan Wang, Chi Jung Hung

и другие.

Science Advances, Год журнала: 2023, Номер 9(1)

Опубликована: Янв. 4, 2023

The mammalian central circadian clock, located in the suprachiasmatic nucleus (SCN), coordinates timing of physiology and behavior to local time cues. In SCN, second messengers, such as cAMP Ca

Язык: Английский

Процитировано

17
Windows into stress: a glimpse at emerging roles for CRHPVN neurons DOI
Neilen P. Rasiah,

Spencer P. Loewen,

Jaideep S. Bains

и другие.

Physiological Reviews, Год журнала: 2022, Номер 103(2), С. 1667 - 1691

Опубликована: Ноя. 17, 2022

The corticotropin-releasing hormone cells in the paraventricular nucleus of hypothalamus (CRHPVN) control slow endocrine response to stress. synapses on these are exquisitely sensitive acute stress, leveraging local signals leave a lasting imprint this system. Additionally, recent work indicates that also play key roles distinct stress and survival behaviors. Here we review observations provide perspective role CRHPVN neurons as integrative malleable hubs for behavioral, physiological, responses

Язык: Английский

Процитировано

26
Hypothalamic corticotrophin releasing hormone neurons in stress‐induced psychopathology: Revaluation of synaptic contributions DOI Creative Commons
Laura M. Stanton, Aidan J. Price, Elizabeth E. Manning

и другие.

Journal of Neuroendocrinology, Год журнала: 2023, Номер 35(4)

Опубликована: Март 30, 2023

Abstract Stress has a strong influence on mental health around the world. Decades of research sought to identify mechanisms through which stress contributes psychiatric disorders such as depression, potentially guide development therapeutics targeting systems. The hypothalamic pituitary adrenal (HPA) axis is key endocrine system that responsible for coordinating body‐wide changes are necessary survival under stress, and much aimed at understanding by depression focussed HPA dysfunction. Corticotrophin releasing hormone (CRH) neurons in paraventricular nucleus hypothalamus (PVN) sit apex axis, integrating signals relevant external threats, ensure activity appropriate given context. In addition this, emerging demonstrated neural PVN CRH regulates related behaviours via modulation downstream synaptic targets. This review will summarize convergent evidence from preclinical studies chronic clinical mood demonstrating function, consider how this may targets neurons, discuss potential role these pathways maladaptive following depression. We also highlight important questions future precisely dissecting roles their interactions, therapeutic opportunities treatment disorders.

Язык: Английский

Процитировано

16
SIK3–HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice DOI Creative Commons
Fuyuki Asano, Staci Jakyong Kim, Tomoyuki Fujiyama

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(11)

Опубликована: Март 6, 2023

Mammals exhibit circadian cycles of sleep and wakefulness under the control suprachiasmatic nucleus (SCN), such as strong arousal phase-locked to beginning dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing delayed peak lengthened behavioral cycle both 12-h light:12-h condition (LD) constant (DD) without changing daily amounts. In contrast, induction a gain-of-function mutant allele Sik3 GABAergic exhibited advanced activity onset shorter period. Loss SIK3 arginine vasopressin (AVP)-producing cycle, but was similar Heterozygous histone deacetylase (HDAC) 4, substrate, shortened whereas mice with HDAC4 S245A, which is resistant phosphorylation by SIK3, phase. Phase-delayed core clock gene expressions were detected liver lacking neurons. These results suggest SIK3-HDAC4 pathway regulates period length timing through NMS-positive SCN.

Язык: Английский

Процитировано

14
Association between sleep duration and kidney stones in 34 190 American adults: A cross-sectional analysis of NHANES 2007-2018 DOI
Shan Yin, Jiahao Wang, Yunjin Bai

и другие.

Sleep Health, Год журнала: 2022, Номер 8(6), С. 671 - 677

Опубликована: Окт. 8, 2022

Язык: Английский

Процитировано

21
Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal DOI Creative Commons
Ying Liu,

Bo Rao,

Shuang Li

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Янв. 28, 2022

Insomnia and anxiety are two common clinical diseases that threaten people's physical mental health. may share some similar underlying neural circuit mechanisms in the brain. In this study, we combine techniques including chemo-fMRI, optogenetics, chemogenetics to reveal glutamatergic neurons of paraventricular hypothalamic nucleus (PVN) regulate both arousal through different downstream circuits. Optogenetic activation PVN-cingulate cortex (Cg) triggers anxiety-like behaviors mice without affecting wakefulness, while optogenetic PVN-paraventricular thalamic (PVT) promotes wakefulness behaviors. Our research reveals PVN is a key brain area for controlling We also provide neurological explanation disorder insomnia which offer guidance treatments drugs or transcranial magnetic stimulation patients.

Язык: Английский

Процитировано

20
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons DOI Creative Commons
Md Tarikul Islam, Florian Rumpf, Yusuke Tsuno

и другие.

Current Biology, Год журнала: 2022, Номер 32(18), С. 3871 - 3885.e4

Опубликована: Июль 30, 2022

Язык: Английский

Процитировано

20
Semi-supervised recognition for artificial intelligence assisted pathology image diagnosis DOI Creative Commons
Pan Yao, Fangfang Gou,

Chunwen Xiao

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 20, 2024

The analysis and interpretation of cytopathological images are crucial in modern medical diagnostics. However, manually locating identifying relevant cells from the vast amount image data can be a daunting task. This challenge is particularly pronounced developing countries where there may shortage expertise to handle such tasks. acquiring large amounts high-quality labelled remains, many researchers have begun use semi-supervised learning methods learn unlabeled data. Although current models partially solve issue limited data, they inefficient exploiting samples. To address this, we introduce new AI-assisted scheme, Reliable-Unlabeled Semi-Supervised Segmentation (RU3S) model. model integrates ResUNet-SE-ASPP-Attention (RSAA) model, which includes Squeeze-and-Excitation (SE) network, Atrous Spatial Pyramid Pooling (ASPP) structure, Attention module, ResUNet architecture. Our leverages effectively, improving accuracy significantly. A novel confidence filtering strategy introduced make better samples, addressing scarcity Experimental results show 2.0% improvement mIoU over state-of-the-art segmentation ST, demonstrating our approach's effectiveness solving this problem.

Язык: Английский

Процитировано

4
Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data DOI Creative Commons

Attila Tóth,

Árpád Dobolyi

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106000 - 106000

Опубликована: Янв. 1, 2025

The role of prolactin in sleep regulation has been the subject extensive research over past 50 years, resulting identification multiple, disparate functions for hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution light. High levels were linked to non-rapid eye movement electroencephalogram delta activity humans. Conversely, hyperprolactinemia showed strong correlation REM rodent studies. may be implicated alterations female patterns observed reproductive cycle, it play enhancement following stress sleep-related immunological processes. In conclusion, appears have sleep-promoting role, particularly phase. However, does not appear central coherent regulation, as some neuropeptides such orexin. its principal function facilitate situational, yet adaptive, changes response challenging physiological phases, those associated stress, challenges, or cycle. Neuronal substrates prolactin-mediated effects remain unknown; however, recent studies provide insights into potential sites these effects.

Язык: Английский

Процитировано

0