Somatostatin regulates central clock function and circadian responses to light DOI Creative Commons

Deborah A. M. Joye,

Kayla E. Rohr,

Kimberlee Suenkens

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(18)

Published: April 25, 2023

Daily and annual changes in light are processed by central clock circuits that control the timing of behavior physiology. The suprachiasmatic nucleus (SCN) anterior hypothalamus processes daily photic inputs encodes day length (i.e., photoperiod), but SCN regulate circadian photoperiodic responses to remain unclear. Somatostatin (SST) expression is modulated photoperiod, role SST has not been examined. Our results indicate signaling regulates rhythms function a manner influenced sex. First, we use cell-fate mapping provide evidence regulated via de novo Sst activation. Next, demonstrate -/- mice display enhanced light, with increased behavioral plasticity jetlag, constant conditions. Notably, lack eliminated sex differences due males, suggesting interacts process differently each also displayed an increase number retinorecipient neurons core, which express type receptor capable resetting molecular clock. Last, show modulates influencing encoding, network after-effects, intercellular synchrony sex-specific manner. Collectively, these insight into peptide mechanisms its response light.

Language: Английский

Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior DOI Creative Commons
Alessandra Porcu, Anna Nilsson,

Sathwik Booreddy

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(35)

Published: Sept. 2, 2022

Seasonal changes in day length (photoperiod) affect numerous physiological functions. The suprachiasmatic nucleus (SCN)–paraventricular (PVN) axis plays a key role processing photoperiod-related information. variations SCN and PVN neurotransmitter expression have been observed humans animal models. However, the molecular mechanisms by which SCN-PVN network responds to altered photoperiod is unknown. Here, we show mice that neuromedin S (NMS) vasoactive intestinal polypeptide (VIP) neurons display photoperiod-induced plasticity. In vivo recording of calcium dynamics revealed NMS alter activity response winter-like photoperiod. Chronic manipulation sufficient induce switching affects locomotor activity. Our findings reveal previously unidentified adaptations seasonality for adjusting hypothalamic function via coordinated multisynaptic affecting behavior.

Language: Английский

Citations

36
Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus DOI Creative Commons
Daisuke Ono, Huan Wang, Chi Jung Hung

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 4, 2023

The mammalian central circadian clock, located in the suprachiasmatic nucleus (SCN), coordinates timing of physiology and behavior to local time cues. In SCN, second messengers, such as cAMP Ca

Language: Английский

Citations

17
Windows into stress: a glimpse at emerging roles for CRHPVN neurons DOI
Neilen P. Rasiah,

Spencer P. Loewen,

Jaideep S. Bains

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(2), P. 1667 - 1691

Published: Nov. 17, 2022

The corticotropin-releasing hormone cells in the paraventricular nucleus of hypothalamus (CRHPVN) control slow endocrine response to stress. synapses on these are exquisitely sensitive acute stress, leveraging local signals leave a lasting imprint this system. Additionally, recent work indicates that also play key roles distinct stress and survival behaviors. Here we review observations provide perspective role CRHPVN neurons as integrative malleable hubs for behavioral, physiological, responses

Language: Английский

Citations

26
Hypothalamic corticotrophin releasing hormone neurons in stress‐induced psychopathology: Revaluation of synaptic contributions DOI Creative Commons
Laura M. Stanton, Aidan J. Price, Elizabeth E. Manning

et al.

Journal of Neuroendocrinology, Journal Year: 2023, Volume and Issue: 35(4)

Published: March 30, 2023

Abstract Stress has a strong influence on mental health around the world. Decades of research sought to identify mechanisms through which stress contributes psychiatric disorders such as depression, potentially guide development therapeutics targeting systems. The hypothalamic pituitary adrenal (HPA) axis is key endocrine system that responsible for coordinating body‐wide changes are necessary survival under stress, and much aimed at understanding by depression focussed HPA dysfunction. Corticotrophin releasing hormone (CRH) neurons in paraventricular nucleus hypothalamus (PVN) sit apex axis, integrating signals relevant external threats, ensure activity appropriate given context. In addition this, emerging demonstrated neural PVN CRH regulates related behaviours via modulation downstream synaptic targets. This review will summarize convergent evidence from preclinical studies chronic clinical mood demonstrating function, consider how this may targets neurons, discuss potential role these pathways maladaptive following depression. We also highlight important questions future precisely dissecting roles their interactions, therapeutic opportunities treatment disorders.

Language: Английский

Citations

16
SIK3–HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice DOI Creative Commons
Fuyuki Asano, Staci Jakyong Kim, Tomoyuki Fujiyama

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(11)

Published: March 6, 2023

Mammals exhibit circadian cycles of sleep and wakefulness under the control suprachiasmatic nucleus (SCN), such as strong arousal phase-locked to beginning dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing delayed peak lengthened behavioral cycle both 12-h light:12-h condition (LD) constant (DD) without changing daily amounts. In contrast, induction a gain-of-function mutant allele Sik3 GABAergic exhibited advanced activity onset shorter period. Loss SIK3 arginine vasopressin (AVP)-producing cycle, but was similar Heterozygous histone deacetylase (HDAC) 4, substrate, shortened whereas mice with HDAC4 S245A, which is resistant phosphorylation by SIK3, phase. Phase-delayed core clock gene expressions were detected liver lacking neurons. These results suggest SIK3-HDAC4 pathway regulates period length timing through NMS-positive SCN.

Language: Английский

Citations

14
Association between sleep duration and kidney stones in 34 190 American adults: A cross-sectional analysis of NHANES 2007-2018 DOI
Shan Yin, Jiahao Wang, Yunjin Bai

et al.

Sleep Health, Journal Year: 2022, Volume and Issue: 8(6), P. 671 - 677

Published: Oct. 8, 2022

Language: Английский

Citations

21
Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal DOI Creative Commons
Ying Liu,

Bo Rao,

Shuang Li

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 28, 2022

Insomnia and anxiety are two common clinical diseases that threaten people's physical mental health. may share some similar underlying neural circuit mechanisms in the brain. In this study, we combine techniques including chemo-fMRI, optogenetics, chemogenetics to reveal glutamatergic neurons of paraventricular hypothalamic nucleus (PVN) regulate both arousal through different downstream circuits. Optogenetic activation PVN-cingulate cortex (Cg) triggers anxiety-like behaviors mice without affecting wakefulness, while optogenetic PVN-paraventricular thalamic (PVT) promotes wakefulness behaviors. Our research reveals PVN is a key brain area for controlling We also provide neurological explanation disorder insomnia which offer guidance treatments drugs or transcranial magnetic stimulation patients.

Language: Английский

Citations

20
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons DOI Creative Commons
Md Tarikul Islam, Florian Rumpf, Yusuke Tsuno

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(18), P. 3871 - 3885.e4

Published: July 30, 2022

Language: Английский

Citations

20
Semi-supervised recognition for artificial intelligence assisted pathology image diagnosis DOI Creative Commons
Pan Yao, Fangfang Gou,

Chunwen Xiao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 20, 2024

The analysis and interpretation of cytopathological images are crucial in modern medical diagnostics. However, manually locating identifying relevant cells from the vast amount image data can be a daunting task. This challenge is particularly pronounced developing countries where there may shortage expertise to handle such tasks. acquiring large amounts high-quality labelled remains, many researchers have begun use semi-supervised learning methods learn unlabeled data. Although current models partially solve issue limited data, they inefficient exploiting samples. To address this, we introduce new AI-assisted scheme, Reliable-Unlabeled Semi-Supervised Segmentation (RU3S) model. model integrates ResUNet-SE-ASPP-Attention (RSAA) model, which includes Squeeze-and-Excitation (SE) network, Atrous Spatial Pyramid Pooling (ASPP) structure, Attention module, ResUNet architecture. Our leverages effectively, improving accuracy significantly. A novel confidence filtering strategy introduced make better samples, addressing scarcity Experimental results show 2.0% improvement mIoU over state-of-the-art segmentation ST, demonstrating our approach's effectiveness solving this problem.

Language: Английский

Citations

4
Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data DOI Creative Commons

Attila Tóth,

Árpád Dobolyi

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106000 - 106000

Published: Jan. 1, 2025

The role of prolactin in sleep regulation has been the subject extensive research over past 50 years, resulting identification multiple, disparate functions for hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution light. High levels were linked to non-rapid eye movement electroencephalogram delta activity humans. Conversely, hyperprolactinemia showed strong correlation REM rodent studies. may be implicated alterations female patterns observed reproductive cycle, it play enhancement following stress sleep-related immunological processes. In conclusion, appears have sleep-promoting role, particularly phase. However, does not appear central coherent regulation, as some neuropeptides such orexin. its principal function facilitate situational, yet adaptive, changes response challenging physiological phases, those associated stress, challenges, or cycle. Neuronal substrates prolactin-mediated effects remain unknown; however, recent studies provide insights into potential sites these effects.

Language: Английский

Citations

0