Science China Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер 36(34)
Опубликована: Сен. 22, 2023
Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation
Язык: Английский
Процитировано
69
Chemical Reviews, Год журнала: 2023, Номер 123(19), С. 11722 - 11773
Опубликована: Сен. 20, 2023
Transient electronic systems represent an emerging class of technology that is defined by ability to fully or partially dissolve, disintegrate, otherwise disappear at controlled rates triggered times through engineered chemical physical processes after a required period operation. This review highlights recent advances in materials chemistry serve as the foundations for subclass transient electronics, bioresorbable characterized resorb (or, equivalently, absorb) biological environment. The primary use cases are designed insert into human body, provide sensing and/or therapeutic functions timeframes aligned with natural processes. Mechanisms bioresorption then harmlessly eliminate devices, and their associated load on risk patient, without need secondary removal surgeries. core content focuses enabling materials, spanning organic inorganic compounds hybrids composites, along mechanisms reaction environments. Following discussions highlight these components, sensors, power supplies, integrated diagnostic formed using specialized methods fabrication assembly. A concluding section summarizes opportunities future research.
Язык: Английский
Процитировано
61
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134615 - 134615
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
22
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 3, 2024
Abstract Abnormal healing following skin injury, such as slow and scar formation, can significantly affect an individual's life. Complex treatment methods cumbersome instruments have reduced the efficacy of treating diseases. In this study, a novel biocompatible liquid metal (LM) composite wound dressing (LGPU) is designed by synthesizing polyurea polyurethane (PU) blending it with LM modified glutathione (GSH), bioactive three‐peptide compound. The effects external electrical stimulation (ES) on wound‐induced hair follicle neogenesis are explored. dressings exhibited few important properties, including conductivity, high stretchability, recyclability, and, most importantly, excellent self‐healing capacity, owing to nature fillers highly dynamic characteristics hydrogen bonds. Furthermore, combination therapy LGPU ES promoted fibroblast migration accelerated healing. wounds treated fully healed in nine days, while blank group still scabbing state. Remarkably, method activate regeneration healthy growth follicles at site which beneficial for reducing scarring. Collectively, innovative provides facile strategy accelerate achieve scar‐free repair.
Язык: Английский
Процитировано
18
Biomaterials, Год журнала: 2024, Номер 308, С. 122566 - 122566
Опубликована: Апрель 8, 2024
Achieving sufficient bone regeneration in large segmental defects is challenging, with the structure of repair scaffolds and their loaded bioactive substances crucial for modulating local osteogenic microenvironment. This study utilized digital laser processing (DLP)-based 3D printing technology to successfully fabricate high-precision methacryloylated polycaprolactone (PCLMA) bionic scaffold structures. Adipose-derived stem cell-engineered nanovesicles (ADSC-ENs) were uniformly stably modified onto surface using a perfusion device, constructing conducive microenvironment tissue long defect through scaffold's structural design vesicles' biological functions. Scanning electron microscopy (SEM) examination confirmed efficient loading ADSC-ENs. The material group vesicles (PCLMA-BAS-ENs) demonstrated good cell compatibility potential when analyzed adhesion osteogenesis primary rabbit marrow mesenchymal cells (BMSCs) on surface. Tested 15 mm critical radial model, PCLMA-BAS-ENs facilitated near-complete after 12 weeks. Immunofluorescence proteomic results indicated that significantly improved at site vivo, promoted angiogenesis, enhanced polarization macrophages towards M2 phenotype, recruitment BMSCs. Thus, was proven promote defects. Overall, this strategy combining engineered highly biomimetic large-segment holds great orthopedic other regenerative medicine applications.
Язык: Английский
Процитировано
15
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 3, 2024
Abstract Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic remote approach for neuromodulation. Developing biodegradable efficient optoelectronic is important achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose biodegradable, flexible, miniaturized silicon-based interface capable of modulation regeneration. Enhancing thin-film molybdenum significantly improves efficacy Our study demonstrates successful activation sciatic in rodents facial rabbits. Moreover, accelerates functional recovery injured nerves.
Язык: Английский
Процитировано
14
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Infection is the most prevalent complication of fractures, particularly in open and often leads to severe consequences.
Язык: Английский
Процитировано
11
Med-X, Год журнала: 2024, Номер 2(1)
Опубликована: Май 21, 2024
Abstract The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells tissues through external force devices or biomaterial-based platforms. In addition situ electroconductive matrices, new class of electroactive biomaterials responsive stimuli has emerged as focal point interest. These materials, response intrinsic biochemical (e.g., glucose) physical light, magnetism, stress), hold significant potential for cell stimulation regeneration. this communication, we underscore distinct category biomaterials, discussing the currently developed biomaterial platforms their biological roles stimulating during healing regeneration process. We also critically evaluate inherent limitations challenges these while offering forward-looking insights into promise future clinical translations. Graphical
Язык: Английский
Процитировано
10
Small, Год журнала: 2024, Номер 21(1)
Опубликована: Окт. 23, 2024
Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.
Язык: Английский
Процитировано
10
Materials Today Bio, Год журнала: 2024, Номер 27, С. 101135 - 101135
Опубликована: Июнь 26, 2024
3D bioprinting technology, a subset of printing is currently witnessing widespread utilization in tissue repair and regeneration endeavors. In particular, light-based technology has garnered significant interest favor. Central to its successful implementation lies the judicious selection photosensitive polymers. Moreover, by fine-tuning parameters such as light irradiation time, choice photoinitiators crosslinkers, their concentrations, properties scaffolds can be tailored suit specific requirements targeted sites. this comprehensive review, we provide an overview commonly utilized bio-inks suitable for bioprinting, delving into distinctive characteristics each material. Furthermore, delineate strategies bio-ink diverse locations, alongside methods optimizing parameters. Ultimately, present coherent synthesis aimed at enhancing practical application engineering, while also addressing current challenges future prospects.
Язык: Английский
Процитировано
9