Flexible Amorphous Silicon Radial Junction Patches Promote Skin Regeneration by Offering Wireless Photoelectric Neuromodulation DOI
Shuyi Wang, Zongguang Liu, Chen Cheng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Photoelectric stimulation offers a promising method for creating noninvasive and durable interfaces with biological tissues, particularly in treating nerve injuries. However, developing flexible high-performance photoelectric stimulators remains challenge. In this study, we present an accessible cost-effective strategy fabricating ultraflexible biocompatible patch designed wireless, light-induced electrical to promote repair skin wounds. Using low-temperature chemical vapor deposition, created films based on three-dimensional (3D) amorphous silicon radial p-i-n junction (RJ) nanowires, which exhibit high open-circuit voltage of 0.79 V short-circuit current 10.5 mA/cm2 under standard AM 1.5 G illumination conditions. The device exhibits good electrochemical performance solution, featuring interfacial capacitance efficient photocurrent generation (∼0.64 mA/cm2), ensures stable, capacitive charge injection crucial effective bioelectrical stimulation. Importantly, the free-standing RJ can be reliably transferred onto soft poly(dimethylsiloxane) substrates produce patches that maintain intimate contact curved tissue surfaces. show biocompatibility effectively enhance neurite outgrowth wound healing safe visible light, promoting both vascular regeneration neural restoration. This holds potential wireless stimulation, providing robust solution comprehensive functional regeneration.

Language: Английский

Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering DOI
Annan Chen, Wanying Wang, Zhengyi Mao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(34)

Published: Sept. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Language: Английский

Citations

65
Advances in Bioresorbable Materials and Electronics DOI
Yamin Zhang, Geumbee Lee, Shuo Li

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(19), P. 11722 - 11773

Published: Sept. 20, 2023

Transient electronic systems represent an emerging class of technology that is defined by ability to fully or partially dissolve, disintegrate, otherwise disappear at controlled rates triggered times through engineered chemical physical processes after a required period operation. This review highlights recent advances in materials chemistry serve as the foundations for subclass transient electronics, bioresorbable characterized resorb (or, equivalently, absorb) biological environment. The primary use cases are designed insert into human body, provide sensing and/or therapeutic functions timeframes aligned with natural processes. Mechanisms bioresorption then harmlessly eliminate devices, and their associated load on risk patient, without need secondary removal surgeries. core content focuses enabling materials, spanning organic inorganic compounds hybrids composites, along mechanisms reaction environments. Following discussions highlight these components, sensors, power supplies, integrated diagnostic formed using specialized methods fabrication assembly. A concluding section summarizes opportunities future research.

Language: Английский

Citations

58
Bioactive polymers: A comprehensive review on bone grafting biomaterials DOI

Sana Pourhajrezaei,

Zahid Abbas, Mohammad Amin Khalili

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134615 - 134615

Published: Aug. 10, 2024

Language: Английский

Citations

19
Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment DOI Creative Commons
Wenbin Jiang,

Yichen Zhan,

Yifan Zhang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122566 - 122566

Published: April 8, 2024

Achieving sufficient bone regeneration in large segmental defects is challenging, with the structure of repair scaffolds and their loaded bioactive substances crucial for modulating local osteogenic microenvironment. This study utilized digital laser processing (DLP)-based 3D printing technology to successfully fabricate high-precision methacryloylated polycaprolactone (PCLMA) bionic scaffold structures. Adipose-derived stem cell-engineered nanovesicles (ADSC-ENs) were uniformly stably modified onto surface using a perfusion device, constructing conducive microenvironment tissue long defect through scaffold's structural design vesicles' biological functions. Scanning electron microscopy (SEM) examination confirmed efficient loading ADSC-ENs. The material group vesicles (PCLMA-BAS-ENs) demonstrated good cell compatibility potential when analyzed adhesion osteogenesis primary rabbit marrow mesenchymal cells (BMSCs) on surface. Tested 15 mm critical radial model, PCLMA-BAS-ENs facilitated near-complete after 12 weeks. Immunofluorescence proteomic results indicated that significantly improved at site vivo, promoted angiogenesis, enhanced polarization macrophages towards M2 phenotype, recruitment BMSCs. Thus, was proven promote defects. Overall, this strategy combining engineered highly biomimetic large-segment holds great orthopedic other regenerative medicine applications.

Language: Английский

Citations

15
Rapid and Scar Free Wound Repair by Using a Biologically Flexible and Conductive Dressing Under Electrical Stimulation DOI

Shuobing Yang,

Zheng‐Dong Yuan,

Tongtong Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Abstract Abnormal healing following skin injury, such as slow and scar formation, can significantly affect an individual's life. Complex treatment methods cumbersome instruments have reduced the efficacy of treating diseases. In this study, a novel biocompatible liquid metal (LM) composite wound dressing (LGPU) is designed by synthesizing polyurea polyurethane (PU) blending it with LM modified glutathione (GSH), bioactive three‐peptide compound. The effects external electrical stimulation (ES) on wound‐induced hair follicle neogenesis are explored. dressings exhibited few important properties, including conductivity, high stretchability, recyclability, and, most importantly, excellent self‐healing capacity, owing to nature fillers highly dynamic characteristics hydrogen bonds. Furthermore, combination therapy LGPU ES promoted fibroblast migration accelerated healing. wounds treated fully healed in nine days, while blank group still scabbing state. Remarkably, method activate regeneration healthy growth follicles at site which beneficial for reducing scarring. Collectively, innovative provides facile strategy accelerate achieve scar‐free repair.

Language: Английский

Citations

15
A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves DOI Creative Commons
Pengcheng Sun,

Chaochao Li,

Can Yang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 3, 2024

Abstract Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic remote approach for neuromodulation. Developing biodegradable efficient optoelectronic is important achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose biodegradable, flexible, miniaturized silicon-based interface capable of modulation regeneration. Enhancing thin-film molybdenum significantly improves efficacy Our study demonstrates successful activation sciatic in rodents facial rabbits. Moreover, accelerates functional recovery injured nerves.

Language: Английский

Citations

12
Biomaterials-enabled electrical stimulation for tissue healing and regeneration DOI Creative Commons
Han‐Sem Kim,

Tanza Baby,

Jung‐Hwan Lee

et al.

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: May 21, 2024

Abstract The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells tissues through external force devices or biomaterial-based platforms. In addition situ electroconductive matrices, new class of electroactive biomaterials responsive stimuli has emerged as focal point interest. These materials, response intrinsic biochemical (e.g., glucose) physical light, magnetism, stress), hold significant potential for cell stimulation regeneration. this communication, we underscore distinct category biomaterials, discussing the currently developed biomaterial platforms their biological roles stimulating during healing regeneration process. We also critically evaluate inherent limitations challenges these while offering forward-looking insights into promise future clinical translations. Graphical

Language: Английский

Citations

10
Light-based 3D bioprinting technology applied to repair and regeneration of different tissues: A rational proposal for biomedical applications DOI Creative Commons
Wenzhuo Fang,

Zhenwei Yu,

Guo Gao

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101135 - 101135

Published: June 26, 2024

3D bioprinting technology, a subset of printing is currently witnessing widespread utilization in tissue repair and regeneration endeavors. In particular, light-based technology has garnered significant interest favor. Central to its successful implementation lies the judicious selection photosensitive polymers. Moreover, by fine-tuning parameters such as light irradiation time, choice photoinitiators crosslinkers, their concentrations, properties scaffolds can be tailored suit specific requirements targeted sites. this comprehensive review, we provide an overview commonly utilized bio-inks suitable for bioprinting, delving into distinctive characteristics each material. Furthermore, delineate strategies bio-ink diverse locations, alongside methods optimizing parameters. Ultimately, present coherent synthesis aimed at enhancing practical application engineering, while also addressing current challenges future prospects.

Language: Английский

Citations

9
Functional Antimicrobial Peptide-loaded 3D Scaffolds for Infected Bone Defect Treatment with AI and Multidimensional Printing DOI
Mengmeng Li, Pin-Yi Zhao, Jingwen Wang

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Infection is the most prevalent complication of fractures, particularly in open and often leads to severe consequences.

Language: Английский

Citations

9
Galvanic cell metasurface modulating electron transfer on polymer implants for sterilization and osteointegration DOI

Shiwei Guan,

Zhiyu Hou,

Xianming Zhang

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100929 - 100929

Published: Jan. 18, 2025

Language: Английский

Citations

1