Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 484 - 484
Опубликована: Апрель 18, 2024
The
antioxidant
and
anti-inflammatory
effects
of
hormetic
nutrition
for
enhancing
stress
resilience
overall
human
health
have
received
much
attention.
Recently,
the
gut-brain
axis
has
attracted
prominent
interest
preventing
therapeutically
impacting
neuropathologies
gastrointestinal
diseases.
Polyphenols
polyphenol-combined
nanoparticles
in
synergy
with
probiotics
shown
to
improve
gut
bioavailability
blood-brain
barrier
(BBB)
permeability,
thus
inhibiting
oxidative
stress,
metabolic
dysfunction
inflammation
linked
dysbiosis
ultimately
onset
progression
central
nervous
system
(CNS)
disorders.
In
accordance
hormesis,
polyphenols
display
biphasic
dose-response
by
activating
at
a
low
dose
Nrf2
pathway
resulting
upregulation
ACS Nano,
Год журнала:
2024,
Номер
18(22), С. 14085 - 14122
Опубликована: Май 22, 2024
Infectious
diseases
pose
a
serious
threat
and
substantial
economic
burden
on
global
human
public
health
security,
especially
with
the
frequent
emergence
of
multidrug-resistant
(MDR)
bacteria
in
clinical
settings.
In
response
to
this
urgent
need,
various
photobased
anti-infectious
therapies
have
been
reported
lately.
This
Review
explores
discusses
several
photochemical
targeted
antibacterial
therapeutic
strategies
for
addressing
bacterial
infections
regardless
their
antibiotic
susceptibility.
contrast
conventional
therapies,
these
approaches
facilitate
precise
targeting
pathogenic
and/or
infectious
microenvironments,
effectively
minimizing
toxicity
mammalian
cells
surrounding
healthy
tissues.
The
highlighted
include
photodynamic
therapy,
photocatalytic
photothermal
endogenous
pigments-based
photobleaching
polyphenols-based
photo-oxidation
therapy.
comprehensive
exploration
aims
offer
updated
information
development
effective,
convenient,
safe,
alternative
counter
growing
MDR
future.
Advanced Materials,
Год журнала:
2024,
Номер
36(19)
Опубликована: Фев. 7, 2024
Current
approaches
to
treating
inflammatory
bowel
disease
focus
on
the
suppression
of
overactive
immune
responses,
removal
reactive
intestinal
oxygen
species,
and
regulation
flora.
However,
owing
complex
structure
gastrointestinal
tract
influence
mucus,
current
small-molecule
biologic-based
drugs
for
colitis
cannot
effectively
act
at
site
colon
inflammation,
as
a
result,
they
tend
exhibit
low
efficacies
toxic
side
effects.
In
this
study,
nanogel-based
multistage
NO
delivery
microcapsules
are
developed
achieve
release
inflammation
by
targeting
tissues
using
nanogel.
Surprisingly,
oral
administration
suppresses
growth
pathogenic
bacteria
increases
abundance
probiotic
bacteria.
Metabolomics
further
show
that
an
increased
probiotics
promotes
production
metabolites,
including
short-chain
fatty
acids
indole
derivatives,
which
modulate
immunity
restore
barrier
via
interleukin-17
PI3K-Akt
signaling
pathways.
This
work
reveals
gas
therapy
strategy
based
modulates
microbial
balance,
thereby
reducing
promoting
repair,
ultimately
providing
new
therapeutic
approach
clinical
management
colitis.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 167 - 180
Опубликована: Янв. 28, 2024
Reactive
oxygen
species
(ROS),
immune
dysregulation-induced
inflammatory
outbreaks
and
microbial
imbalance
play
critical
roles
in
the
development
of
bowel
disease
(IBD).
Herein,
a
novel
enzyme-like
biomimetic
oral-agent
ZnPBA@YCW
has
been
developed,
using
yeast
cell
wall
(YCW)
as
outer
shell
zinc-doped
Prussian
blue
analogue
(ZnPBA)
nanozyme
inside.
When
orally
administered,
is
able
to
adhere
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Апрель 25, 2024
Abstract
The
regeneration
of
hypoxia‐impaired
chronic
tissue
defects
has
long
been
challenging,
mainly
due
to
the
inefficiency
oxygenation
and
limited
biological
activity
existing
oxygen
delivery
systems
in
regulating
dynamic
process.
Herein,
a
novel
polyphenol‐copper
coordination
strategy
fabricate
bioactive
superoxide
dismutase‐catalase
self‐cascade
nanozymes
(SalB‐CuNCs)
is
reported,
which
can
serve
as
an
situ
oxygenator
induce
angiogenesis
simultaneously.
copper‐phenolic
hydroxyl
structure
SalB‐CuNCs
plays
critical
role
promoting
enzyme‐like
cascade
reaction
via
catechol‐mediated
Cu
valence
state
transition
substrate
capture
mechanism.
Furthermore,
after
incorporating
into
Schiff
base
hydrogel
(COC@SalB‐Cu),
resulting
system
exhibits
outstanding
antioxidant
robust
effect
mitigating
hypoxic
microenvironment.
Benefiting
from
intrinsic
angiogenic
SalB
copper,
COC@SalB‐Cu
more
complete
tube
formation
by
up‐regulating
expression
level
vascular
endothelial
growth
factor
(VEGF),
platelet‐endothelial
cell
adhesion
molecule‐1
(CD31),
nitric
oxide
synthase
(eNOS).
In
vivo
experiments
further
demonstrate
that
significantly
restore
blood
supply,
leading
fast
regeneration.
present
holds
enormous
promise
for
treatment
hypoxia‐related
injury
field
regenerative
medicine.
Advanced Materials,
Год журнала:
2023,
Номер
36(6)
Опубликована: Сен. 19, 2023
Abstract
Compared
to
injection
administration,
oral
administration
is
free
of
discomfort,
wound
infection,
and
complications
has
a
higher
compliance
rate
for
patients
with
diverse
diseases.
However,
reduces
the
bioavailability
medicines,
especially
biologics
(e.g.,
peptides,
proteins,
antibodies),
due
harsh
gastrointestinal
biological
barriers.
In
this
context,
development
prosperity
nanotechnology
have
helped
improve
bioactivity
availability
medicines.
On
basis,
first,
barriers
are
discussed,
then
nanomedicine
based
on
organic
inorganic
nanomaterials
their
biomedical
applications
in
diseases
reviewed.
Finally,
challenges
potential
opportunities
future
nanomedicine,
which
may
provide
vital
reference
eventual
clinical
transformation
standardized
production
put
forward.
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Июль 29, 2024
Abstract
The
biosafety
concerns
associated
with
fecal
microbiota
transplant
(FMT)
limit
their
clinical
application
in
treating
ulcerative
colitis
(UC).
Gut
secrete
abundant
extracellular
vesicles
(Gm‐EVs),
which
play
a
critical
role
bacteria‐to‐bacteria
and
bacteria‐to‐host
communications.
Herein,
intestinal
are
trained
using
tea
leaf
lipid/pluronic
F127‐coated
curcumin
nanocrystals
(CN@Lp
127
s),
can
maintain
stability
during
transit
through
the
gastrointestinal
tract.
Compared
FMT,
Gm‐EVs
derived
from
healthy
mice
significantly
improve
treatment
outcomes
against
UC
by
reducing
colonic
inflammatory
responses,
restoring
barrier
function,
rebalancing
microbiota.
Strikingly,
obtained
CN@Lp
‐trained
exhibit
superior
therapeutic
effect
on
compared
to
groups
receiving
FMT
mice,
mice.
Oral
administration
of
not
only
alleviates
inflammation,
promotes
mucosal
repair,
regulates
gut
but
also
purine
metabolism
decrease
uric
acid
level,
resulting
robust
improvement
UC.
This
study
demonstrates
efficacy
nanomedicine‐trained
regulating
immune
microenvironment,
microbiota,
colon.
These
EVs
provide
an
alternative
platform
replace
as
for
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(4), С. 2188 - 2200
Опубликована: Янв. 17, 2024
A
highly
stretchable
and
self-adhesive
wearable
biosensor
is
prepared
from
nanozyme-catalyzed
conductive
hydrogels.
The
hydrogels
are
first
a
nanozyme
(Ta–Ag)
based
on
polyphenol
(tannic
acid,
Ta)
chelate
with
metal
ions
(silver
ion,
Ag+),
which
possesses
peroxidase
(POD)-like
activity.
After
that,
huge
number
of
free
radicals
formed
by
the
interaction
between
Ta–Ag
NPs
ammonium
persulfate
(APS),
initiate
hydrogel
polymerization
via
facile
"one-pot"
compositing
strategy
without
ultraviolet
(UV)
or
thermal
treatment.
homogeneous
distribution
nanozymes
in
interpenetrating
network
sodium
alginate
(SA)
polyacrylamide
(PAAm)
realizes
dermis-mimicking
structure
flexible
conductor,
named
Ta–Ag–SA/PAAm.
It
simultaneously
improves
mechanical
properties
conductivity.
Similar
to
adhesion
mussels,
contain
abundant
phenolic
hydroxyl
groups,
favoring
adhesiveness
Due
capability
changing
conductivity
strain,
obtained
able
accurately
monitor
different
amplitudes
human
activities
real
time.
In
addition,
exhibits
good
bacterial
thereby
enhances
bactericidal
efficiency
Ag.
Based
high
performance
sensing
antibacterial
activity,
Ta–Ag–SA/PAAm
can
be
promising
candidate
for
broad
range
applications,
such
as
adhesive
epidemic
biosensors
medical
patches.
Accounts of Materials Research,
Год журнала:
2024,
Номер
5(3), С. 271 - 285
Опубликована: Фев. 16, 2024
ConspectusCatalytic
biomaterials,
an
emerging
frontier
in
biomaterials
research,
offer
tremendous
potential
to
circumvent
the
limitations
of
traditional
treatment
approaches,
such
as
low
specificity
and
adverse
effects.
By
harnessing
intrinsic
physicochemical
properties
materials,
catalytic
especially
nanoscale
(termed
nanomedicine),
can
directly
engage
with
a
range
biogenic
substrates
initiate
various
chemical
or
biochemical
reactions
vivo.
Chemically
designed
nanozymes
emulate
endogenous
enzymes
regulating
intracellular
redox
homeostasis,
offering
distinct
advantages
over
their
natural
counterparts,
design
flexibility,
adjustable
functionalities,
robust
stability
harsh
conditions,
cost-effective
production.
The
extensively
investigated
mimicked
by
include
peroxidases,
oxidases,
superoxide
dismutases,
catalase,
glutathione
peroxidase.
To
improve
enzyme-mimicking
activities
properties,
composition,
size,
morphology,
exposed
crystal
facets,
surface
chemistry,
are
finely
tuned
for
reactive
oxygen
species
(ROS)-producing
pro-oxidative
ROS-eliminating
antioxidative
applications.
As
interdisciplinary
research
catalysis
biomedicine
deepens,
cutting-edge
concepts
catalysis,
including
single-atom
photocatalysis,
electrocatalysis,
piezoelectric
thermoelectric
have
gradually
merged
biomaterials.
resultant
be
activated
spatiotemporally
light,
ultrasound,
magnetic
fields,
heat,
etc.,
beyond
scope
aforementioned
endogenously
responsive
nanozymes.
Given
semiconductor
nature
these
externally
defect
engineering
heterojunction
strategies
utilized
enhance
separation
suppress
recombination
electron–hole
pairs
modulating
bandgap
structures.
Consequently,
efficacy
rationally
engineered
generating
scavenging
ROS
profoundly
improved.
Apart
from
ROS-centered
applications,
content
has
also
been
extended
transformation
substrates,
depletion,
glucose/lactate
consumption,
gas
production
inorganic
nanocatalysts.
Collectively,
which
purposefully
influence
cellular
homeostasis
regulate
cell
signaling
pathways,
assumed
play
pivotal
role
addressing
spectrum
pathophysiological
disorders
associated
oxidative
stress
dysfunctions,
cancer,
inflammation,
immunomodulation,
neurodegeneration,
cardiovascular
diseases.
connections
among
nanomedicine,
nanozymes,
we
present
our
insights
here
clarify
distinctions.
Catalytic
broader
scope,
spanning
nanoscale,
microscale,
macroscale
that
possess
specific
activities.
involved
encompass
both
enzyme-mimetic
well
endogenously/exogenously
initiated
nanomedicine
emphasizes
integration
nanotechnology
therapeutic
Nanozymes
specifically
focus
on
nanomaterials.
Thus,
utilize
term
"catalytic
biomaterials"
describe
this
fast-evolving
field
anticipate
will
motivate
deeper
between
materials
science,
medicine.In
Account,
provide
concise
introduction
fundamental
understanding
categorizing
them
into
three
groups
based
action
mechanisms.
Then,
highlight
group's
work
fabrication
diverse
biomedical
cancer
therapy,
antibacterial,
anti-inflammation,
tissue
engineering,
regenerative
medicine
Our
primary
is
deliberate
tailor-made
application
sophisticated
scenarios.
biological
effects
arising
elucidated.
Furthermore,
perspectives
clinical
translation
discussed.
We
envision
rapid
development
could
spur
evolution
highly
effective
therapeutic/regenerative
approaches
minimal
toxicity
wide
medical
conditions.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 28, 2024
Biomaterial-mediated
bone
tissue
engineering
(BTE)
offers
an
alternative,
interesting
approach
for
the
restoration
of
damaged
tissues
in
postsurgery
osteosarcoma
treatment.
This
study
focused
on
synthesizing
innovative
composite
inks,
integrating
self-assembled
silk
fibroin
(SF),
tannic
acids
(TA),
and
electrospun
bioactive
glass
nanofibers
70SiO2-25CaO-5P2O5
(BGNF).
By
synergistically
combining
unique
characteristics
these
three
components
through
self-assembly
microextrusion-based
three-dimensional
(3D)
printing,
our
goal
was
to
produce
durable
versatile
aerogel-based
3D
scaffolds.
These
scaffolds
were
designed
exhibit
hierarchical
porosity
along
with
antibacterial,
antiosteosarcoma,
regeneration
properties.
Taking
inspiration
from
mussel
foot
protein
attachment
chemistry
involving
coordination
dihydroxyphenylalanine
(DOPA)
amino
ferric
ions
(Fe3+),
we
synthesized
a
tris-complex
catecholate-iron
gel.
gel
formation
occurred
oxidized
SF
(SFO)
TA
polydopamine-modified
BGNF
(BGNF-PDA).
The
dynamic
nature
ligand–metal
bonds
within
SFO
matrix
provided
excellent
shear-thinning
properties,
allowing
SFO-TA-BGNF
complex
be
extruded
nozzle,
facilitating
printing
into
outstanding
shape
fidelity.
Moreover,
developed
aerogels
exhibited
multifaceted
features,
including
NIR-triggered
photothermal
antibacterial
vitro
antiosteosarcoma
In
studies
showcased
their
biocompatibility
osteogenic
features
as
seeded
cells
successfully
differentiated
osteoblasts,
promoting
21
days.
Through
comprehensive
characterizations
biological
validations,
scaffold
demonstrated
promise
exceptional
platform
concurrent
cancer
therapy,
setting
stage
potential
clinical
application.
