bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
Disorders
of
consciousness
(DoC),
including
the
unresponsive
wakefulness
syndrome
(UWS)
and
minimally
conscious
state
(MCS),
have
limited
treatment
options.
Recent
research
suggests
that
psychedelic
drugs,
known
for
their
complexity-enhancing
properties,
could
be
promising
treatments
DoC.
This
study
uses
whole-brain
computational
models
to
explore
this
potential.
We
created
individualised
DoC
patients,
optimised
with
empirical
fMRI
diffusion-weighted
imaging
(DWI)
data,
simulated
administration
LSD
psilocybin.
used
an
in-silico
perturbation
protocol
distinguish
between
different
states
consciousness,
DoC,
anaesthesia,
state,
assess
dynamical
stability
brains
patients
pre-
post-psychedelic
simulation.
Our
findings
indicate
psilocybin
shift
patients'
closer
criticality,
a
greater
effect
in
MCS
patients.
In
UWS
response
correlates
structural
connectivity,
while
it
aligns
baseline
functional
connectivity.
virtual
clinical
trial
lays
foundation
using
psychedelics
highlights
future
role
modelling
drug
discovery
personalised
medicine.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
150, С. 105193 - 105193
Опубликована: Апрель 21, 2023
The
human
brain
exhibits
complex
interactions
across
micro,
meso-,
and
macro-scale
organisational
principles.
Recent
synergistic
multi-modal
approaches
have
begun
to
link
micro-scale
information
systems
level
dynamics,
transcending
hierarchies
offering
novel
perspectives
into
the
brain's
function
dysfunction.
Specifically,
distribution
of
properties
(such
as
receptor
density
or
gene
expression)
can
be
mapped
onto
measures
from
functional
MRI
provide
neurobiological
insights.
Methodological
enrich
imaging
analyses
with
molecular
are
rapidly
evolving,
several
streams
research
having
developed
relatively
independently,
each
unique
potential
explore
trans-hierarchical
functioning
brain.
Here,
we
address
three
principal
-
spatial
correlation,
molecular-enriched
network,
in-silico
whole
modelling
a
critical
overview
different
sources
information,
how
this
utilised
within
fMRI
data,
merits
pitfalls
methodology,
and,
through
use
key
examples,
highlight
their
promise
shed
new
light
on
domains
neuroscientific
inquiry.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 11, 2024
Abstract
A
central
challenge
of
neuroscience
is
to
elucidate
how
brain
function
supports
consciousness.
Here,
we
combine
the
specificity
focal
deep
stimulation
with
fMRI
coverage
entire
cortex,
in
awake
and
anaesthetised
non-human
primates.
During
propofol,
sevoflurane,
or
ketamine
anaesthesia,
subsequent
restoration
responsiveness
by
electrical
thalamus,
investigate
loss
consciousness
impacts
distributed
patterns
structure-function
organisation
across
scales.
We
report
that
activity
under
anaesthesia
increasingly
constrained
structure
scales,
coinciding
anaesthetic-induced
collapse
multiple
dimensions
hierarchical
cortical
organisation.
These
signatures
are
observed
different
anaesthetics,
they
reversed
recovery
behavioural
markers
arousal.
No
such
effects
were
upon
stimulating
ventral
lateral
demonstrating
specificity.
Overall,
identify
consistent
orchestrated
specific
thalamic
nuclei.
Abstract
Study
Objectives
This
study
aimed
to
investigate
the
alterations
in
resting-state
electroencephalography
(EEG)
global
brain
connectivity
(GBC)
patients
with
chronic
insomnia
disorder
(CID)
and
explore
correlation
between
macroscale
connectomic
variances
microscale
neurotransmitter
distributions.
Methods
We
acquired
64-channel
EEG
from
35
female
CID
34
healthy
females.
signals
were
source-localized
using
individual
anatomy
orthogonalized
mitigate
volume
conduction.
Correlation
coefficients
band-limited
source-space
power
envelopes
of
DK
68
atlas
computed
averaged
across
regions
determine
specific
GBC
values.
A
support
vector
machine
(SVM)
classifier
utilizing
features
was
employed
differentiate
controls.
further
used
Neurosynth
a
3D
receptors/transporters
assess
cognitive
functions
landscape
associated
cortical
abnormality
maps,
respectively.
Results
exhibited
elevated
within
medial
prefrontal
cortex
limbic
cortex,
particularly
at
gamma
carrier
frequency,
compared
controls
(pFDR
<
.05).
patterns
found
effectively
distinguish
precision
90.8%
SVM
model.
The
maps
significantly
correlated
meta-analytic
terms
like
“cognitive
control”
“emotion
regulation.”
Notably,
profiles
(pspin
.05),
systems
such
as
norepinephrine,
dopamine,
serotonin
making
significant
contributions.
Conclusions
work
characterizes
profile
CID,
facilitating
cost-effective
clinical
translation
EEG-derived
markers.
Additionally,
linkage
distribution
offers
promising
avenues
for
developing
targeted
treatment
strategies
CID.
Trends in Neurosciences,
Год журнала:
2024,
Номер
47(7), С. 551 - 568
Опубликована: Май 31, 2024
Disentangling
how
cognitive
functions
emerge
from
the
interplay
of
brain
dynamics
and
network
architecture
is
among
major
challenges
that
neuroscientists
face.
Pharmacological
pathological
perturbations
consciousness
provide
a
lens
to
investigate
these
complex
challenges.
Here,
we
review
recent
advances
about
brain's
functional
organisation
have
been
driven
by
common
denominator:
decomposing
function
into
fundamental
constituents
time,
space,
information.
Whereas
unconsciousness
increases
structure-function
coupling
across
scales,
psychedelics
may
decouple
structure.
Convergent
effects
also
emerge:
anaesthetics,
psychedelics,
disorders
can
exhibit
similar
reconfigurations
unimodal-transmodal
axis.
Decomposition
approaches
reveal
potential
translate
discoveries
species,
with
computational
modelling
providing
path
towards
mechanistic
integration.
Neuroscience of Consciousness,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Modern
medicine
has
been
shaken
by
the
surge
of
psychedelic
science
that
proposes
a
new
approach
to
mitigate
mental
disorders,
such
as
depression
and
post-traumatic
stress
disorder.
Clinical
trials
investigate
whether
substances
can
treat
psychiatric
conditions
are
now
underway,
yet
less
discussion
gravitates
around
their
use
in
neurological
disorders
due
brain
injury.
One
suggested
implementation
brain-complexity
enhancing
psychedelics
is
people
with
post-comatose
consciousness
(DoC).
In
this
article,
we
discuss
rationale
endeavour,
examining
possible
outcomes
experiments
postulating
existence
an
optimal
level
complexity.
We
consider
counterintuitive
effects
both
DoC
on
functional
connectivity
default
mode
network
its
impact
selfhood.
also
elaborate
role
computational
modelling
providing
complementary
information
experimental
studies,
contributing
our
understanding
treatment
mechanisms
path
towards
personalized
medicine.
Finally,
update
discourse
surrounding
ethical
considerations,
encompassing
clinical
scientific
values.
Human Brain Mapping,
Год журнала:
2025,
Номер
46(4)
Опубликована: Март 1, 2025
ABSTRACT
This
study
integrated
neuroimaging
and
neurochemistry
data
to
explore
brain
mechanisms
in
chronic
insomnia
disorder
(CID)
the
neuromodulatory
effects
of
acupuncture.
We
analyzed
a
cross‐sectional
arterial
spin
labeling
(ASL)
dataset
(
N
=
197)
CID
patients
healthy
controls
identify
cerebral
blood
flow
(CBF)
changes.
Additionally,
longitudinal
ASL
44)
examined
CBF
changes
after
4‐week
acupuncture
treatment
or
on
waitlist.
then
assessed
impact
19
neurotransmitter
receptors/transporters
these
alterations.
In
comparisons,
exhibited
increased
cortical
areas
decreased
subcortical
regions,
correlating
with
severity.
enhanced
alleviated
symptoms,
not
observed
waitlist
group.
The
left
putamen
was
identified
as
an
overlapping
region
involved
both
CID‐related
post‐treatment
Moreover,
patterns
induced
by
negatively
correlated
abnormal
patients,
were
significantly
associated
GABAa
dopamine‐D1
receptor
densities.
decrease
could
potentially
serve
neural
biomarker
for
CID,
while
may
alleviate
symptoms
increasing
this
region,
through
modulation
D1
expressions.
