A virtual clinical trial of psychedelics to treat patients with disorders of consciousness DOI Open Access
Naji Alnagger, Paolo Cardone, Charlotte Martial

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Disorders of consciousness (DoC), including the unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), have limited treatment options. Recent research suggests that psychedelic drugs, known for their complexity-enhancing properties, could be promising treatments DoC. This study uses whole-brain computational models to explore this potential. We created individualised DoC patients, optimised with empirical fMRI diffusion-weighted imaging (DWI) data, simulated administration LSD psilocybin. used an in-silico perturbation protocol distinguish between different states consciousness, DoC, anaesthesia, state, assess dynamical stability brains patients pre- post-psychedelic simulation. Our findings indicate psilocybin shift patients' closer criticality, a greater effect in MCS patients. In UWS response correlates structural connectivity, while it aligns baseline functional connectivity. virtual clinical trial lays foundation using psychedelics highlights future role modelling drug discovery personalised medicine.

Language: Английский

Nonlinear modeling of financial state variables and multiscale numerical analysis DOI
Zifei Lin, Haibing Zhao,

Z.Z. Sun

et al.

The European Physical Journal Special Topics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

3
From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging DOI Creative Commons
Timothy Lawn, Matthew A. Howard, Federico Turkheimer

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105193 - 105193

Published: April 21, 2023

The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information systems level dynamics, transcending hierarchies offering novel perspectives into the brain's function dysfunction. Specifically, distribution of properties (such as receptor density or gene expression) can be mapped onto measures from functional MRI provide neurobiological insights. Methodological enrich imaging analyses with molecular are rapidly evolving, several streams research having developed relatively independently, each unique potential explore trans-hierarchical functioning brain. Here, we address three principal - spatial correlation, molecular-enriched network, in-silico whole modelling a critical overview different sources information, how this utilised within fMRI data, merits pitfalls methodology, and, through use key examples, highlight their promise shed new light on domains neuroscientific inquiry.

Language: Английский

Citations

25
Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain DOI Creative Commons
Andrea I. Luppi, Lynn Uhrig, Jordy Tasserie

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 11, 2024

Abstract A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity focal deep stimulation with fMRI coverage entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, subsequent restoration responsiveness by electrical thalamus, investigate loss consciousness impacts distributed patterns structure-function organisation across scales. We report that activity under anaesthesia increasingly constrained structure scales, coinciding anaesthetic-induced collapse multiple dimensions hierarchical cortical organisation. These signatures are observed different anaesthetics, they reversed recovery behavioural markers arousal. No such effects were upon stimulating ventral lateral demonstrating specificity. Overall, identify consistent orchestrated specific thalamic nuclei.

Language: Английский

Citations

13
Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community DOI
Jessica Royer, Casey Paquola, Sofie L. Valk

et al.

Neuroinformatics, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Language: Английский

Citations

10
Electroencephalography connectome changes in chronic insomnia disorder are correlated with neurochemical signatures DOI
Liyong Yu, Wei Peng, Wenting Lin

et al.

SLEEP, Journal Year: 2024, Volume and Issue: 47(7)

Published: March 23, 2024

Abstract Study Objectives This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) patients with chronic insomnia disorder (CID) and explore correlation between macroscale connectomic variances microscale neurotransmitter distributions. Methods We acquired 64-channel EEG from 35 female CID 34 healthy females. signals were source-localized using individual anatomy orthogonalized mitigate volume conduction. Correlation coefficients band-limited source-space power envelopes of DK 68 atlas computed averaged across regions determine specific GBC values. A support vector machine (SVM) classifier utilizing features was employed differentiate controls. further used Neurosynth a 3D receptors/transporters assess cognitive functions landscape associated cortical abnormality maps, respectively. Results exhibited elevated within medial prefrontal cortex limbic cortex, particularly at gamma carrier frequency, compared controls (pFDR < .05). patterns found effectively distinguish precision 90.8% SVM model. The maps significantly correlated meta-analytic terms like “cognitive control” “emotion regulation.” Notably, profiles (pspin .05), systems such as norepinephrine, dopamine, serotonin making significant contributions. Conclusions work characterizes profile CID, facilitating cost-effective clinical translation EEG-derived markers. Additionally, linkage distribution offers promising avenues for developing targeted treatment strategies CID.

Language: Английский

Citations

5
Unravelling consciousness and brain function through the lens of time, space, and information DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(7), P. 551 - 568

Published: May 31, 2024

Disentangling how cognitive functions emerge from the interplay of brain dynamics and network architecture is among major challenges that neuroscientists face. Pharmacological pathological perturbations consciousness provide a lens to investigate these complex challenges. Here, we review recent advances about brain's functional organisation have been driven by common denominator: decomposing function into fundamental constituents time, space, information. Whereas unconsciousness increases structure-function coupling across scales, psychedelics may decouple structure. Convergent effects also emerge: anaesthetics, psychedelics, disorders can exhibit similar reconfigurations unimodal-transmodal axis. Decomposition approaches reveal potential translate discoveries species, with computational modelling providing path towards mechanistic integration.

Language: Английский

Citations

4
Psychedelics and disorders of consciousness: the current landscape and the path forward DOI Creative Commons
Paolo Cardone, Naji Alnagger, Jitka Annen

et al.

Neuroscience of Consciousness, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Modern medicine has been shaken by the surge of psychedelic science that proposes a new approach to mitigate mental disorders, such as depression and post-traumatic stress disorder. Clinical trials investigate whether substances can treat psychiatric conditions are now underway, yet less discussion gravitates around their use in neurological disorders due brain injury. One suggested implementation brain-complexity enhancing psychedelics is people with post-comatose consciousness (DoC). In this article, we discuss rationale endeavour, examining possible outcomes experiments postulating existence an optimal level complexity. We consider counterintuitive effects both DoC on functional connectivity default mode network its impact selfhood. also elaborate role computational modelling providing complementary information experimental studies, contributing our understanding treatment mechanisms path towards personalized medicine. Finally, update discourse surrounding ethical considerations, encompassing clinical scientific values.

Language: Английский

Citations

4
Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms DOI Creative Commons
Ahmed Faraz Khan, Yasser Iturria‐Medina

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 23, 2024

Language: Английский

Citations

4
Connectome harmonic decomposition tracks the presence of disconnected consciousness during ketamine-induced unresponsiveness DOI Creative Commons
Milan Van Maldegem, Jakub Vohryzek, Selen Atasoy

et al.

British Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine‐D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture DOI Creative Commons
Liyong Yu, Lili Yang, Xiaoqin Chen

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(4)

Published: March 1, 2025

ABSTRACT This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) the neuromodulatory effects of acupuncture. We analyzed a cross‐sectional arterial spin labeling (ASL) dataset ( N = 197) CID patients healthy controls identify cerebral blood flow (CBF) changes. Additionally, longitudinal ASL 44) examined CBF changes after 4‐week acupuncture treatment or on waitlist. then assessed impact 19 neurotransmitter receptors/transporters these alterations. In comparisons, exhibited increased cortical areas decreased subcortical regions, correlating with severity. enhanced alleviated symptoms, not observed waitlist group. The left putamen was identified as an overlapping region involved both CID‐related post‐treatment Moreover, patterns induced by negatively correlated abnormal patients, were significantly associated GABAa dopamine‐D1 receptor densities. decrease could potentially serve neural biomarker for CID, while may alleviate symptoms increasing this region, through modulation D1 expressions.

Language: Английский

Citations

0