The Blood–Brain Barrier

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(1), С. a020412 - a020412

Опубликована: Янв. 1, 2015

Richard Daneman1 and Alexandre Prat2 1Departments of Neuroscience Pharmacology, University California, San Diego, California 92093 2Department Neuroscience, Université de Montréal, Quebec H2X 0A9, Canada Correspondence: rdaneman{at}ucsd.edu

Язык: Английский

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cell, Год журнала: 2019, Номер 179(2), С. 312 - 339

Опубликована: Сен. 26, 2019

Язык: Английский

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Human Hippocampal Neurogenesis Persists throughout Aging

Cell stem cell, Год журнала: 2018, Номер 22(4), С. 589 - 599.e5

Опубликована: Апрель 1, 2018

Язык: Английский

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Ageing, neurodegeneration and brain rejuvenation

Nature, Год журнала: 2016, Номер 539(7628), С. 180 - 186

Опубликована: Ноя. 1, 2016

Язык: Английский

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Angiocrine functions of organ-specific endothelial cells

Nature, Год журнала: 2016, Номер 529(7586), С. 316 - 325

Опубликована: Янв. 1, 2016

Язык: Английский

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Proteostasis and aging

Nature Medicine, Год журнала: 2015, Номер 21(12), С. 1406 - 1415

Опубликована: Дек. 1, 2015

Язык: Английский

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Physiological and pathological cardiac hypertrophy

Journal of Molecular and Cellular Cardiology, Год журнала: 2016, Номер 97, С. 245 - 262

Опубликована: Июнь 2, 2016

Язык: Английский

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Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

Science, Год журнала: 2014, Номер 344(6184), С. 649 - 652

Опубликована: Май 6, 2014

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting blood contains humoral "rejuvenating" factors can restore regenerative function. Here, we demonstrate the circulating protein growth differentiation factor 11 (GDF11) rejuvenating for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, heterochronic parabiosis or delivery recombinant protein, reversed functional impairments and restored genomic integrity muscle stem cells (satellite cells). Increased levels also improved structural features increased strength endurance exercise capacity. These data systemically regulates aging may be therapeutically useful reversing age-related cell dysfunction.

Язык: Английский

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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Cell Metabolism, Год журнала: 2015, Номер 22(1), С. 86 - 99

Опубликована: Июнь 18, 2015

Язык: Английский

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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

Cell stem cell, Год журнала: 2015, Номер 17(4), С. 385 - 395

Опубликована: Окт. 1, 2015

Язык: Английский

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