The Blood–Brain Barrier

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(1), P. a020412 - a020412

Published: Jan. 1, 2015

Richard Daneman1 and Alexandre Prat2 1Departments of Neuroscience Pharmacology, University California, San Diego, California 92093 2Department Neuroscience, Université de Montréal, Quebec H2X 0A9, Canada Correspondence: rdaneman{at}ucsd.edu

Language: Английский

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cell, Journal Year: 2019, Volume and Issue: 179(2), P. 312 - 339

Published: Sept. 26, 2019

Language: Английский

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Human Hippocampal Neurogenesis Persists throughout Aging

Cell stem cell, Journal Year: 2018, Volume and Issue: 22(4), P. 589 - 599.e5

Published: April 1, 2018

Language: Английский

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Ageing, neurodegeneration and brain rejuvenation

Nature, Journal Year: 2016, Volume and Issue: 539(7628), P. 180 - 186

Published: Nov. 1, 2016

Language: Английский

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Angiocrine functions of organ-specific endothelial cells

Nature, Journal Year: 2016, Volume and Issue: 529(7586), P. 316 - 325

Published: Jan. 1, 2016

Language: Английский

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Proteostasis and aging

Nature Medicine, Journal Year: 2015, Volume and Issue: 21(12), P. 1406 - 1415

Published: Dec. 1, 2015

Language: Английский

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Physiological and pathological cardiac hypertrophy

Journal of Molecular and Cellular Cardiology, Journal Year: 2016, Volume and Issue: 97, P. 245 - 262

Published: June 2, 2016

Language: Английский

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Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

Science, Journal Year: 2014, Volume and Issue: 344(6184), P. 649 - 652

Published: May 6, 2014

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting blood contains humoral "rejuvenating" factors can restore regenerative function. Here, we demonstrate the circulating protein growth differentiation factor 11 (GDF11) rejuvenating for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, heterochronic parabiosis or delivery recombinant protein, reversed functional impairments and restored genomic integrity muscle stem cells (satellite cells). Increased levels also improved structural features increased strength endurance exercise capacity. These data systemically regulates aging may be therapeutically useful reversing age-related cell dysfunction.

Language: Английский

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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Cell Metabolism, Journal Year: 2015, Volume and Issue: 22(1), P. 86 - 99

Published: June 18, 2015

Language: Английский

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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

Cell stem cell, Journal Year: 2015, Volume and Issue: 17(4), P. 385 - 395

Published: Oct. 1, 2015

Language: Английский

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