Resistance Mechanisms to Anti-PD Cancer Immunotherapy DOI
Matthew D. Vesely,

Tianxiang Zhang,

Lieping Chen

и другие.

Annual Review of Immunology, Год журнала: 2022, Номер 40(1), С. 45 - 74

Опубликована: Апрель 26, 2022

The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1 (B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However, only a fraction patients with solid tumors and some hematopoietic malignancies respond to anti-PD therapy, reason for failure in other is less known. By dissecting mechanisms underlying this resistance, current studies reveal that tumor microenvironment major location resistance occur. Furthermore, appear be highly heterogeneous. Here, we discuss recent human data identifying therapy. We review evidence immune-based such as loss neoantigens, defects antigen presentation interferon signaling, immune inhibitory molecules, exclusion T cells. also clinical emerging alterations metabolism, microbiota, epigenetics. Finally, strategies overcome therapy emphasize need develop additional immunotherapies based on concept normalization immunotherapy.

Язык: Английский

Pancreatic cancer: Advances and challenges DOI Creative Commons
Christopher J. Halbrook, Costas A. Lyssiotis, Marina Pasca di Magliano

и другие.

Cell, Год журнала: 2023, Номер 186(8), С. 1729 - 1754

Опубликована: Апрель 1, 2023

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. tumors are characterized by a complex microenvironment that orchestrates metabolic alterations supports milieu interactions among various cell types within this niche. In review, we highlight foundational studies driven our understanding these processes. We further discuss recent technological advances continue to expand complexity. posit clinical translation research endeavors will enhance currently dismal survival rate recalcitrant disease.

Язык: Английский

Процитировано

605

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion DOI
Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk

и другие.

Nature Immunology, Год журнала: 2021, Номер 22(2), С. 205 - 215

Опубликована: Янв. 4, 2021

Язык: Английский

Процитировано

581

Mitochondrial Metabolism as a Target for Cancer Therapy DOI Creative Commons

Karthik Vasan,

M.D. Werner, Navdeep S. Chandel

и другие.

Cell Metabolism, Год журнала: 2020, Номер 32(3), С. 341 - 352

Опубликована: Июль 14, 2020

Язык: Английский

Процитировано

528

Metabolomics in cancer research and emerging applications in clinical oncology DOI Open Access

Daniel R. Schmidt,

Rutulkumar Patel, David G. Kirsch

и другие.

CA A Cancer Journal for Clinicians, Год журнала: 2021, Номер 71(4), С. 333 - 358

Опубликована: Май 13, 2021

Abstract Cancer has myriad effects on metabolism that include both rewiring of intracellular to enable cancer cells proliferate inappropriately and adapt the tumor microenvironment, changes in normal tissue metabolism. With recognition fluorodeoxyglucose‐positron emission tomography imaging is an important tool for management many cancers, other metabolites biological samples have been spotlight diagnosis, monitoring, therapy. Metabolomics global analysis small molecule like ‐omics technologies can provide critical information about state are otherwise not apparent. Here, authors review how therapies interact with at cellular systemic levels. An overview metabolomics provided a focus currently available they applied clinical translational research setting. The also discuss could be further leveraged future improve patients cancer.

Язык: Английский

Процитировано

504

Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism DOI
Ilaria Elia, Marcia C. Haigis

Nature Metabolism, Год журнала: 2021, Номер 3(1), С. 21 - 32

Опубликована: Янв. 4, 2021

Язык: Английский

Процитировано

443

Amino Assets: How Amino Acids Support Immunity DOI Creative Commons
Beth Kelly, Erika L. Pearce

Cell Metabolism, Год журнала: 2020, Номер 32(2), С. 154 - 175

Опубликована: Июль 9, 2020

Язык: Английский

Процитировано

433

CD8+ T cell metabolism in infection and cancer DOI
Miguel Reina‐Campos, Nicole E. Scharping, Ananda W. Goldrath

и другие.

Nature reviews. Immunology, Год журнала: 2021, Номер 21(11), С. 718 - 738

Опубликована: Май 12, 2021

Язык: Английский

Процитировано

401

Metabolic barriers to cancer immunotherapy DOI
Kristin DePeaux, Greg M. Delgoffe

Nature reviews. Immunology, Год журнала: 2021, Номер 21(12), С. 785 - 797

Опубликована: Апрель 29, 2021

Язык: Английский

Процитировано

393

The evolving metabolic landscape of chromatin biology and epigenetics DOI
Ziwei Dai, Vijyendra Ramesh, Jason W. Locasale

и другие.

Nature Reviews Genetics, Год журнала: 2020, Номер 21(12), С. 737 - 753

Опубликована: Сен. 9, 2020

Язык: Английский

Процитировано

368

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells DOI Open Access
Min Hee Oh, Im‐Hong Sun, Liang Zhao

и другие.

Journal of Clinical Investigation, Год журнала: 2020, Номер 130(7), С. 3865 - 3884

Опубликована: Апрель 23, 2020

Myeloid cells comprise a major component of the tumor microenvironment (TME) that promotes growth and immune evasion. By employing small-molecule inhibitor glutamine metabolism, not only were we able to inhibit growth, but markedly inhibited generation recruitment myeloid-derived suppressor (MDSCs). Targeting metabolism led decrease in CSF3 hence MDSCs as well immunogenic cell death, leading an increase inflammatory tumor-associated macrophages (TAMs). Alternatively, inhibiting themselves activation-induced death conversion macrophages. Surprisingly, blocking also IDO expression both cells, marked kynurenine levels. This turn development metastasis further enhanced antitumor immunity. Indeed, targeting rendered checkpoint blockade-resistant tumors susceptible immunotherapy. Overall, our studies define intimate interplay between unique suppressive cells.

Язык: Английский

Процитировано

319