Hallmarks of Health

Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63

Опубликована: Дек. 18, 2020

Язык: Английский

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Communicating clocks shape circadian homeostasis

Science, Год журнала: 2021, Номер 371(6530)

Опубликована: Фев. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Язык: Английский

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Insect Diapause

Опубликована: Янв. 13, 2022

Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation changes and enactment mechanisms for bringing development halt then reinitiating it when inimical season is past. The dormant state diapause serves bridge unfavourable seasons, its timing provides powerful mechanism synchronizing development. book explores how signals are monitored used by insects enact specific molecular pathways that generate phenotype. broad perspective offered here scales from ecological thus comprehensive view this exciting vibrant research field, offering insights on topics ranging pest management, evolution, speciation, climate change disease transmission, human health, as well analogies with other forms invertebrate dormancy mammalian hibernation.

Язык: Английский

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Rhythmic cilia changes support SCN neuron coherence in circadian clock

Science, Год журнала: 2023, Номер 380(6648), С. 972 - 979

Опубликована: Июнь 1, 2023

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for coupling among SCN neurons maintain the robustness of internal in mice. Cilia neuromedin S-producing (NMS) exhibit pronounced rhythmicity abundance and length. Genetic ablation ciliogenesis NMS enabled a rapid phase shift under jet-lag conditions. rhythms individual cilia-deficient slices lost their after external Rhythmic changes drive oscillations Sonic Hedgehog (Shh) signaling gene expression. Inactivation Shh phenocopied effects ablation. Thus, cilia-Shh aids coupling.

Язык: Английский

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A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

The Innovation, Год журнала: 2023, Номер 4(1), С. 100380 - 100380

Опубликована: Янв. 1, 2023

•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.

Язык: Английский

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Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

Nature Cancer, Год журнала: 2024, Номер 5(4), С. 546 - 556

Опубликована: Апрель 23, 2024

Язык: Английский

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The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response

Archives of Toxicology, Год журнала: 2021, Номер 95(6), С. 1943 - 1970

Опубликована: Май 18, 2021

Язык: Английский

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Coupled network of the circadian clocks: a driving force of rhythmic physiology

FEBS Letters, Год журнала: 2020, Номер 594(17), С. 2734 - 2769

Опубликована: Авг. 4, 2020

The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt daily changes in their environment. In mammals, clocks form a hierarchically organized network with ‘master clock’ located the suprachiasmatic nucleus hypothalamus, which ensures entrainment subsidiary environmental cycles. Robust rhythmicity body indispensable for temporally coordinating organ functions, disruption or misalignment rhythms caused instance by modern lifestyle strongly associated various widespread diseases. This review aims provide comprehensive overview our current knowledge about molecular architecture system‐level organization mammalian oscillators. Furthermore, we discuss regulatory roles peripheral cell physiology implication temporal coordination metabolism human health disease. Finally, summarize methods assessing humans.

Язык: Английский

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Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Янв. 15, 2021

Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought drive these in most of cells. However, red blood cells (RBCs), which do not contain a nucleus, cannot perform transcription or translation, nonetheless exhibit circadian redox rhythms. Here we show human RBCs display regulation glucose metabolism, is required sustain daily oscillations. We found rhythms metabolite levels flux through glycolysis the pentose phosphate pathway (PPP). that inhibition critical enzymes either abolished metabolic oscillations, determined oscillations necessary for rhythmicity. Furthermore, also occur nucleated cells, persist when core transcriptional clockwork absent Bmal1 knockouts. Thus, propose rhythmic metabolism an integral process

Язык: Английский

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The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation

Cellular and Molecular Gastroenterology and Hepatology, Год журнала: 2021, Номер 12(5), С. 1847 - 1872.e0

Опубликована: Янв. 1, 2021

Circadian rhythms are daily physiological oscillations driven by the circadian clock: a 24-hour transcriptional timekeeper that regulates hormones, inflammation, and metabolism. known to be important for health, but whether their loss contributes colorectal cancer is not known. We tested nonredundant clock gene Bmal1 in intestinal homeostasis tumorigenesis, using Apcmin model of cancer.Bmal1 mutant, epithelium-conditional photoperiod (day/night cycle) disrupted mice bearing allele were assessed tumorigenesis. Tumors normal nontransformed tissue characterized. Intestinal organoids transcription RNA sequencing, vivo organoid assays used test Bmal1-dependent proliferation self-renewal.Loss or increases tumor initiation. In epithelium transcripts involved regeneration stem cell signaling. have no self-autonomous function only weak vivo. clock-disrupted tumors show high Yes-associated protein 1 (Hippo signaling) activity low Wnt (Wingless Int-1) activity. self-renewal 1-dependent manner.Bmal1 pathways, including Hippo signaling, potentiates Transcript profiling: GEO accession number: GSE157357.

Язык: Английский

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