Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115479 - 115479
Опубликована: Ноя. 1, 2024
Язык: Английский
BMEMat, Год журнала: 2024, Номер 2(2)
Опубликована: Янв. 12, 2024
Abstract Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression, long‐term protection from recurrence as well minimized side effects, the low response rate significantly limits clinical application of in board types solid tumors. In order to improve therapeutic efficacy, conventional therapies including radiotherapy, chemotherapy, phototherapy and chemodynamic are employed combine with elicit stronger antitumor immune responses. Polymer nanomedicines frequently utilized synergistic other owing their tunable physiochemical properties, high drug loading capacity, ease modification toxicity. With elaborate design tailored polymer can enhance efficacy enhancing specificity, priming cells amplifying responses However, until now, there is no review solely dedicated comprehensive development polymer‐based platforms for combinational cancers. Herein, this paper summarizes latest advances design, fabrication traditional strategies photothermal therapy, photodynamic therapies. An outlook on trajectory potential challenges bridging gap between also discussed.
Язык: Английский
Процитировано
25
Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 161 - 161
Опубликована: Янв. 24, 2024
With the development of nanotechnology and confronting problems traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable for diseases allow precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol deposition rates, increasing bioavailability. They are expected to solve difficulties faced diseases. However, limited success has been recorded industrialization translation nano-formulations. Only one relevant product approved by FDA date, suggesting that there still many issues be resolved clinical application These systems characterized a dependence on inhalation devices, while adaptability device formulation is inconclusive, which most important issue impeding translational research. In this review, we categorized various nano-formulations, summarized advantages over conventional formulations, listed undergoing studies. We focused influence devices analyzed their adaptability. After extensive analysis delivery mechanisms, technical processes, limitations different concluded vibrating mesh nebulizers might suitable delivering related examples were introduced validate our view. Finally, presented challenges outlook future development. anticipate providing an informative reference field.
Язык: Английский
Процитировано
22
Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(5), С. 367 - 369
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
22
Light Science & Applications, Год журнала: 2024, Номер 13(1)
Опубликована: Сен. 3, 2024
Abstract Chemotherapy is one of the conventional treatments for cancer in clinical practice. However, poor delivery efficiency, systemic toxicity, and lack pharmacokinetic monitoring during treatment are critical limitations current chemotherapy. Herein, we reported a brand-new antitumor drug strategy that harnesses an optical fiber endoscopically therapeutic probe. The probe carries photosensitizers core agents on surface mediated by temperature-responsive hydrogel film, giving rise to activable photothermal-chemotherapy orchestrates localized hyperthermia thermal-stimuli release tumor lesion. Furthermore, dynamical in-situ temperature can be real-time supervised through built-in sensors, including reflective Mach–Zehnder interferometer Bragg grating, visualize therapy process thus improve safety treatment. Compared with methods, fiber-optic adequately take advantage chemotherapeutics collaboratively recruiting photoheating-mediated enhanced permeability particle-assisted high retention, shedding new light “central-to-peripheral” pervasion retention mechanism destroy tumors completely. chemotherapy incorporates precise delivery, accurate controllability release, tumor, low off-target rate, feedback, performing straightforward pathway. More than that, proposed holds tremendous promise provide revolutionized on-demand platform highly efficient evaluation screening pharmaceuticals.
Язык: Английский
Процитировано
21
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Abstract Lattice metamaterials emerge as advanced architected materials with superior physical properties and significant potential for lightweight applications. Recent developments in additive manufacturing (AM) techniques facilitate the of lattice intricate microarchitectures promote their applications multi‐physical scenarios. Previous reviews on have largely focused a specific/single field, limited discussion properties, interaction mechanisms, multifunctional Accordingly, this article critically design principles, structure‐mechanism‐property relationships, enabled by AM techniques. First, are categorized into homogeneous lattices, inhomogeneous other forms, whose principles processes discussed, including benefits drawbacks different fabricating types lattices. Subsequently, structure–mechanism–property relationships mechanisms range fields, mechanical, acoustic, electromagnetic/optical, thermal disciplines, summarized to reveal critical principles. Moreover, metamaterials, such sound absorbers, insulators, manipulators, sensors, actuators, soft robots, management, invisible cloaks, biomedical implants, enumerated. These provide effective guidelines
Язык: Английский
Процитировано
9
Bioactive Materials, Год журнала: 2024, Номер 39, С. 163 - 190
Опубликована: Май 21, 2024
Oral administration is the most simple, noninvasive, convenient treatment. With increasing demands on targeted drug delivery, traditional oral treatment now facing some challenges: 1) biologics how to implement and ensure bioavailability not lower than subcutaneous injections; 2) How achieve therapy of drugs in gastrointestinal tract? Based these two issues, delivery microrobots have shown great application prospect due their characteristics flexible locomotion or driven ability. Therefore, this paper summarizes various developed recent years divides them into four categories according different driving modes: magnetic-controlled microrobots, anchored self-propelled biohybrid microrobots. As involve disciplines such as materials science, mechanical engineering, medicine, control systems, begins by introducing barriers that must overcome. Subsequently, it provides an overview typical involved design process To enhance readers' understanding working principles we present a guideline for designing Furthermore, current development status types reviewed, summarizing respective advantages limitations. Finally, considering significant concerns regarding safety clinical translation, discuss challenges prospections translation presented paper, providing corresponding suggestions addressing existing challenges.
Язык: Английский
Процитировано
13
Science Robotics, Год журнала: 2024, Номер 9(87)
Опубликована: Фев. 28, 2024
Medical devices actuated by external magnetic fields can create opportunities for clinical adoption of precision telesurgery.
Язык: Английский
Процитировано
11
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Micro/nanorobots (MNRs) are envisioned to provide revolutionary changes therapies for infectious diseases as they can deliver various antibacterial agents or energies many hard-to-reach infection sites. However, existing MNRs face substantial challenges in addressing complex infections that progress from superficial deep tissues. Here, we develop swarming magnetic Fe 3 O 4 @polydopamine-tannic acid nanorobots (Fe @PDA-TA NRs) capable of performing targeted bacteria elimination complicated bacterial by integrating photothermal and chemical strategies. The nanoparticles (NPs), serving building blocks the nanorobots, fabricated situ polymerization dopamine followed TA adhesion. When driven alternating fields, NPs assemble into large energetic microswarms continuously flowing forward with tunable velocity. Thus, NRs be navigated achieve rapid broad coverage a area distance rapidly eradicate residing there upon exposure near-infrared (NIR) light due their efficient conversion. Additionally, concentrate at sites traversing through confined, narrow, tortuous passages, exerting sustained action surface TA-induced easy cell adhesion subsequent membrane destruction. Therefore, show great potential superficial-to-deep infections. This study may inspire development future therapeutic microsystems multifunction synergies, task flexibility, high efficiency.
Язык: Английский
Процитировано
11
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115201 - 115201
Опубликована: Фев. 6, 2024
Язык: Английский
Процитировано
10
Nano Letters, Год журнала: 2024, Номер 24(20), С. 5958 - 5967
Опубликована: Май 13, 2024
Micro/nanorobots hold the potential to revolutionize biomedicine by executing diverse tasks in hard-to-reach biological environments. Nevertheless, achieving precise drug delivery unknown disease sites using swarming micro/nanorobots remains a significant challenge. Here we develop heterogeneous swarm comprising sensing microrobots (sensor-bots) and drug-carrying (carrier-bots) with collaborative tasking capabilities for toward sites. Leveraging robust interspecific hydrodynamic interactions, sensor-bots carrier-bots spontaneously synchronize self-organize into stable microswarms. Given that can create real-time pH maps employing pH-responsive structural-color changes doxorubicin-loaded exhibit selective adhesion acidic targets via charge reversal, sensor-carrier microswarm, when exploring environments, detect localize uncharted targets, guide itself cover area, finally deploy therapeutic precisely there. This versatile platform holds promise treating diseases localized acidosis inspires future theranostic microsystems expandability, task flexibility, high efficiency.
Язык: Английский
Процитировано
10