Brain-Gut-Microbiota Axis in Amyotrophic Lateral Sclerosis: A Historical Overview and Future Directions DOI Creative Commons

Shilan Chen,

Xinhong Cai,

Lin Lao

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: 15(1), P. 74 - 74

Published: Jan. 1, 2024

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease which strongly associated with age. The incidence of ALS increases from the age 40 and peaks between ages 65 70. Most patients die respiratory muscle paralysis or lung infections within three to five years appearance symptoms, dealing huge blow their families. With aging populations, improved diagnostic methods changes in reporting criteria, likely show an upward trend coming decades. Despite extensive researches have been done, cause pathogenesis remains unclear. In recent decades, large quantities studies focusing on gut microbiota shown that its metabolites seem change evolvement through brain-gut-microbiota axis, turn, progression will exacerbate imbalance microbiota, thereby forming vicious cycle. This suggests further exploration identification function may be crucial break bottleneck diagnosis treatment this disease. Hence, current review summarizes discusses latest research advancement future directions so as help relevant researchers gain correlative information instantly.

Language: Английский

Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review DOI Open Access

Min’an Zhao,

Jiayi Chu,

Shiyao Feng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114985 - 114985

Published: June 11, 2023

The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.

Language: Английский

Citations

115
Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration DOI Creative Commons

Riddhi Solanki,

Anjali A. Karande, Prathibha Ranganathan

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: May 15, 2023

Alzheimer's disease (AD), is a chronic age-related progressive neurodegenerative disorder, characterized by neuroinflammation and extracellular aggregation of Aβ peptide. affects every 1 in 14 individuals aged 65 years above. Recent studies suggest that the intestinal microbiota plays crucial role modulating neuro-inflammation which turn influences deposition. The gut brain interact with each other through nervous system chemical means via blood-brain barrier, termed Microbiota Gut Brain Axis (MGBA). It suggested can impact host's health, numerous factors, such as nutrition, pharmacological interventions, lifestyle, geographic location, alter composition. Although, exact relationship between dysbiosis AD still elusive, several mechanisms have been proposed drivers their implications pathology, include, action bacteria produce bacterial amyloids lipopolysaccharides causing macrophage dysfunction leading to increased permeability, hyperimmune activation inflammatory cytokines (IL-1β, IL-6, IL-8, NLRP3), impairment gut- blood barrier deposition brain, etc. study micro-organisms associated aid appropriate model organisms has recognized phyla Bacteroidetes Firmicutes contain genus Escherichia, Lactobacillus, Clostridium , etc., contribute significantly pathology. Modulating various means, use prebiotics, probiotics, antibiotics or fecal matter transplantation, thought be potential therapeutic intervention for treatment AD. This review aims summarize our current knowledge on possible dysbiosis, axis neuroinflammation, application novel targeted approaches modulate

Language: Английский

Citations

67
Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance DOI Open Access

Prabhakar Tiwari,

Rekha Dwivedi, Manisha Bansal

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(4), P. 1650 - 1650

Published: Feb. 19, 2023

In humans, the gut microbiota (GM) are known to play a significant role in metabolism of nutrients and drugs, immunomodulation, pathogen defense by inhabiting gastrointestinal tract (GIT). The GM gut–brain axis (GBA) has been documented for different regulatory mechanisms associated pathways it shows behaviors with individualized bacteria. addition, as susceptibility factor neurological disorders central nervous system (CNS), regulating disease progression being amenable intervention. Bidirectional transmission between brain occurs GBA, implying that performs neurocrine, endocrine, immune-mediated signaling pathways. regulates multiple supplementing them prebiotics, probiotics, postbiotics, synbiotics, fecal transplantations, and/or antibiotics. A well-balanced diet is critically important establishing healthy GM, which can alter enteric (ENS) regulate disorders. Here, we have discussed function GBA from gut, neurology interacts various GM. Furthermore, highlighted recent advances future prospects may require addressing research concerns about

Language: Английский

Citations

49
Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders DOI Open Access
Yadong Zheng, Laura Bonfili, Tao Wei

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4631 - 4631

Published: Oct. 31, 2023

The gut–brain axis (GBA) is a complex bidirectional communication network connecting the gut and brain. It involves neural, immune, endocrine pathways between gastrointestinal (GI) tract central nervous system (CNS). Perturbations of GBA have been reported in many neurodegenerative disorders (NDDs), such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), among others, suggesting possible role pathogenesis. microbiota pivotal component GBA, alterations its composition, known dysbiosis, associated with dysfunction neurodegeneration. might influence homeostasis CNS by modulating immune and, more directly, regulating production molecules metabolites that systems, making it potential therapeutic target. Preclinical trials manipulating microbial composition through dietary intervention, probiotic prebiotic supplementation, fecal transplantation (FMT) provided promising outcomes. However, clear mechanism not well understood, results are always consistent. Here, we provide an overview major components approaches targeting to ameliorate NDDs.

Language: Английский

Citations

45
Efficacy of fecal microbiota transplantation in patients with Parkinson’s disease: clinical trial results from a randomized, placebo-controlled design DOI Creative Commons
Yi Cheng,

Guohua Tan,

Qihui Zhu

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Dec. 6, 2023

The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related gut dysbiosis, however, the impact fecal microbiota transplantation (FMT) on engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at Department Neurology, Army Medical University Southwest Hospital China (ChiCTR1900021405) from February 2019 December 2019. Fifty-six participants with mild moderate (Hoehn-Yahr stage 1–3) were randomly assigned FMT placebo group, 27 group completed whole trial. During follow-up, no severe adverse effect was observed, treatment showed significant improvement PD-related autonomic symptoms compared end this (MDS-UPDRS total score, group×time effect, B = -6.56 [−12.98, −0.13], P < 0.05). Additionally, improved gastrointestinal disorders marked increase complexity microecological system patients. This study that through oral administration clinically feasible has potential improve effectiveness current medications clinical

Language: Английский

Citations

43
Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3 DOI Creative Commons
Wenzhi Hao, Qingyu Ma, Lu Wang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 20, 2024

Abstract Background Remodeling eubiosis of the gut microenvironment may contribute to preventing occurrence and development depression. Mounting experimental evidence has shown that complement C3 signaling is associated with pathogenesis depression, disruption microbiota be an underlying cause system activation. However, mechanism by which participates in gut-brain crosstalk depression remains unknown. Results In present study, we found chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well cognitive impairment, was significant dysbiosis, especially enrichment Proteobacteria elevation microbiota-derived lipopolysaccharides (LPS). addition, peripheral central activation C3/CR3-mediated aberrant synaptic pruning microglia have also been observed. Transplantation from CUMS-induced model into specific pathogen-free germ-free induced concomitant impairment recipient mice, accompanied increased C3/CR3 pathway prefrontal cortex abnormalities microglia-mediated pruning. Conversely, antidepressants fecal transplantation antidepressant-treated donors improved behaviors restored microbiome disturbances depressed mice. Concurrently, inhibition pathway, amelioration abnormal pruning, expression synapsin postsynaptic density protein 95 were Collectively, our results revealed dysbiosis induces through synapse C3, key targeting microbes treat Conclusions Our findings provide novel insights involvement chemotactic

Language: Английский

Citations

28
The regulatory effect of polysaccharides on the gut microbiota and their effect on human health: A review DOI
Hongkun Xue,

Beimeng Liang,

Yu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132170 - 132170

Published: May 9, 2024

Language: Английский

Citations

28
Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder DOI

Cong-Ya Chen,

Yufei Wang, Lan Lei

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122815 - 122815

Published: June 11, 2024

Language: Английский

Citations

19
Interkingdom signaling between gastrointestinal hormones and the gut microbiome DOI Creative Commons
Xinyu Zhao, Ye Qiu,

Lanfan Liang

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in health of host development diseases. As vital component intestinal microecosystem, influences synthesis release many through mechanisms such as modulating environment, producing metabolites, impacting mucosal barriers, generating immune inflammatory responses, releasing neurotransmitters. Conversely, exert feedback regulation on by nutrient absorption utilization, bacterial biological behavior composition. distributions are anatomically intertwined, close interactions crucial for maintaining homeostasis. Interventions leveraging have been employed clinical management metabolic diseases bowel diseases, bariatric surgery fecal transplantation, offering promising targets treatment dysbiosis-related

Language: Английский

Citations

2
Association of gut microbiome and primary liver cancer: A two‐sample Mendelian randomization and case–control study DOI
Jun Ma, Jialiang Li, Jin Chen

et al.

Liver International, Journal Year: 2022, Volume and Issue: 43(1), P. 221 - 233

Published: Oct. 27, 2022

Observational epidemiology studies suggested a relationship between the gut microbiome and primary liver cancer. However, causal remains unclear because of confounding factors reverse causality. We aimed to explore role in development cancer, including hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC).

Language: Английский

Citations

61