Academic Crisis During COVID 19: Online Classes, a Panacea for Imminent Doctors

Indian Journal of Otolaryngology and Head & Neck Surgery, Год журнала: 2020, Номер 74(1), С. 45 - 49

Опубликована: Окт. 17, 2020

Язык: Английский

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Addressing standardized definitions of post-COVID and long-COVID

Clinical Chemistry and Laboratory Medicine (CCLM), Год журнала: 2023, Номер 61(8), С. 1361 - 1362

Опубликована: Апрель 25, 2023

Язык: Английский

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Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125552 - 125552

Опубликована: Июнь 24, 2023

Язык: Английский

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Programmable Gravity Self‐Driven Microfluidic Chip for Point‐of‐Care Multiplied Immunoassays

Small, Год журнала: 2023, Номер 20(21)

Опубликована: Дек. 12, 2023

Abstract Point‐of‐care testing (POCT) is experiencing a groundbreaking transformation with microfluidic chips, which offer precise fluid control and manipulation at the microscale. Nevertheless, chip design or operation for existing platforms rather cumbersome, some even heavily depending on external drivers devices, impeding their broader utilization. This study develops unique programmable gravity self‐driven (PGSMC) capable of simultaneous multi‐reagent sequential release, multi‐target analysis, multi‐chip operation. All necessary reagents are introduced in single step, process initiated simply by flipping PGSMC vertically, eliminating need additional steps devices. Additionally, it demonstrates successful immunoassays less than 60 min antinuclear antibodies testing, compared to more 120 traditional methods. Assessment using 25 clinically diagnosed cases showcases remarkable sensitivity (96%), specificity (100%), accuracy (99%). These outcomes underscored its potential as promising platform POCT high accuracy, speed, reliability, highlighting capability automated control.

Язык: Английский

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Relevance of comorbidities for main outcomes during different periods of the COVID‐19 pandemic

Influenza and Other Respiratory Viruses, Год журнала: 2024, Номер 18(1)

Опубликована: Янв. 1, 2024

Abstract Background Throughout the evolution of COVID‐19 pandemic, severity disease has varied. The aim this study was to determine how patients' comorbidities affected and were related to, different outcomes during time. Methods Retrospective cohort all patients testing positive for SARS‐CoV‐2 infection between March 1, 2020, January 9, 2022. We extracted sociodemographic, basal comorbidities, prescribed treatments, vaccination data, such as death admission hospital intensive care unit (ICU) periods pandemic. used logistic regression quantify effect each covariate in outcome variable a random forest algorithm select most relevant comorbidities. Results Predictors included having dementia, heart failure, kidney disease, or cancer, while arterial hypertension, diabetes, ischemic heart, cerebrovascular, peripheral vascular diseases, leukemia also relevant. Heart cancer predictors adverse (death ICU admission) with Arterial kidney, hospitalization, dyslipidemia respiratory, diseases Conclusions Preexisting cardiovascular renal cancers those outcomes. Of particular note discrepancies hospitalization fact that dementia had lower probability being admitted first wave.

Язык: Английский

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Research on optimization of emergency supplies customs clearance strategy from the perspective of public health security based on Chinese trade data

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Янв. 24, 2025

Background This study is significant for improving the accuracy of Customs’ cross-border supervision emergency supplies and ensuring timely clearance these essential goods. Methods To ensure both convenience security Customs oversight regarding supplies, this first systematically collects organizes representative data on import export trade supplies. Proposed an enhanced Recency Frequency Monetary (RFM) cluster analysis model, building principles k-means clustering. Subsequently, model employed to Finally, paper offers optimization suggestions customs based results. Results The primarily focuses collection organization across six major categories By employing K-means clustering techniques, research develops improved RFM referred as TR-TF-TV, subsequently proposes strategies integrating advanced TR-TF-TV. It These include a safe efficient clearance, preservation integrity stability within supply chain, enhancement national management system, improvement response capabilities public health emergencies. Conclusion concerning represents exploratory initiative in original design. Recognizing inherent limitations associated with model’s index design sample selection, we intend refine elements future research, aiming improve validate further optimize related countermeasures.

Язык: Английский

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Impact of COVID-19 pandemic on unresectable pancreatic cancer: a regional cohort study in Japan

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The COVID-19 pandemic has had a significant impact on healthcare, including cancer management. This study aimed to investigate the prognostic of pandemic, throughout its duration, patient care for pancreatic ductal adenocarcinoma (PDAC). We collected clinical data patients with unresectable PDAC who underwent palliative chemotherapy at five medical facilities in Fukushima, Japan. were divided into two groups: group A (nonpandemic cohort) and B (pandemic cohort). Survival analysis was performed progression-free survival (PFS) overall (OS) via Kaplan‒Meier method log-rank test. In total, 249 selected analysis. Patients Group significantly greater serum CA19-9 levels proportions combination therapy; however, we did not find differences between groups PFS (Group vs. B: 5.6 months 4.4 months, HR = 0.82 (95% CI, 0.6-1.1), p 0.17) or OS (14.8 12.3 0.81 0.7-1.3), 0.81) observe negative prognosis pandemic.

Язык: Английский

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Vibrio parahaemolyticus: Exploring its Incidence in Malaysia and the Potential of Streptomyces sp. as an Anti-Vibrio Agent

Progress In Microbes & Molecular Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Июнь 10, 2023

As the world recovers from COVID-19 pandemic, concern remains for future potential outbreaks because of persisting effects climate change, including proliferation infectious diseases. The frequent isolation Vibrio parahaemolyticus in surrounding environment is as it can cause infections marine animals and transmitted to humans. V. leading foodborne gastroenteritis worldwide. Malaysia one top seafood consumers this places us at a higher risk exposure infections. Over years, pathogen has been isolated various sources Malaysia, mainly such shellfish, shrimps, fish. To make matters worse, there an emergence antibiotic-resistant worldwide, which attributed uncontrolled use antibiotics aquaculture prevent treat vibriosis. Therefore, vital utilize alternatives probiotics control further propagation strains bacteria. A candidate Streptomyces sp., class filamentous, Gram-positive bacteria that produce variety bioactive compounds during their life cycle, be useful drug discovery. produced by sp. have proven microbiota-modulating stimulatory on host, enhancing immunity providing protective against With application aquaculture, efficacy available preserved, spread antibiotic resistance reduced.

Язык: Английский

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Early suppression policies protected pregnant women from COVID‐19 in 2020: A population‐based surveillance from the Nordic countries

Acta Obstetricia Et Gynecologica Scandinavica, Год журнала: 2024, Номер 103(6), С. 1063 - 1072

Опубликована: Фев. 21, 2024

Abstract Introduction The Coronavirus 2019 Disease (COVID‐19) pandemic reached the Nordic countries in March 2020. Public health interventions to limit viral transmission varied across different both timing and magnitude. Interventions indicated by an Oxford Stringency Index ≥50 were implemented early (March 13–17, 2020) Denmark, Finland, Norway Iceland, on 26, 2020 Sweden. aim of current study was assess incidence COVID‐19‐related admissions pregnant women relation national public strategies during first year pandemic. Material methods This is a meta‐analysis population‐based cohort studies five with or regional surveillance Obstetric Surveillance System (NOSS) collaboration: data from Iceland Norway, covering 31% births source population consisted giving birth included areas 1–December 31, Pregnant positive SARS‐CoV‐2 PCR test ≤14 days before hospital admission included, stratified as either non‐COVID (other obstetric healthcare). Information about policies retrieved retrospectively. Results In total, 392 382 maternities considered. Of these, 600 diagnosed infection 137 (22.8%) admitted for COVID‐19 symptoms. pooled per 1000 0.5 (95% confidence interval [CI] 0.2 1.2, I 2 = 77.6, tau 0.68, P 0.0), ranging no 1.9 Swedish regions. restrict less stringent Sweden than other countries. Conclusions There clear variation women's risk similar healthcare systems but transmission. indicates that suppression protected severe disease prior availability individual protection vaccines.

Язык: Английский

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Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome

Microbiology Spectrum, Год журнала: 2024, Номер 12(10)

Опубликована: Авг. 20, 2024

ABSTRACT The COVID-19 pandemic persists despite the availability of vaccines, and it is, therefore, crucial to develop new therapeutic preventive approaches. In this study, we investigated potential role oral microbiome in SARS-CoV-2 infection. Using an vitro pseudovirus infection assay, found a potent inhibitory effect exerted by Porphyromonas gingivalis on mediated known P. compounds such as phosphoglycerol dihydroceramide (PGDHC) gingipains well unknown bacterial factors. We that gingipain-mediated inhibition is likely due cytotoxicity, whereas PGDHC inhibited virus mechanism. Unidentified factors present supernatant via fusion step life cycle. addressed other bacteria certain periodontal pathogens capable inhibiting inducing cytotoxicity target cells. human cavity, observed modulatory activity microbial communities varied among individuals, some saliva-based cultures were while others enhancing These findings contribute our understanding complex relationship between viral infections, offering avenues for innovative strategies combating COVID-19. IMPORTANCE important health disease, Our studies suggest produce could potentially inhibit elucidating interactions will be pathogenesis development against

Язык: Английский

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