The Role of Fenugreek in the Management of Type 2 Diabetes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6987 - 6987

Published: June 26, 2024

The number of people diagnosed with type 2 diabetes is on the increase worldwide. Of growing concern, prevalence in children and youths increasing rapidly mirrors burden childhood obesity. There are many risk factors associated condition; some due to lifestyle, but beyond our control, such as genetics. an urgent need develop better therapeutics for prevention management this complex condition since current medications often cause unwanted side effects, poorly managed can result onset related comorbidities. Naturally derived compounds have gained momentum preventing managing several conditions, including diabetes. Here, we provide update benefits limitations fenugreek its components a therapeutic diabetes, bioavailability interaction microbiome.

Language: Английский

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Diabetes Technology in People with Type 2 Diabetes: Novel Indications

Current Diabetes Reports, Journal Year: 2024, Volume and Issue: 24(5), P. 85 - 95

Published: Feb. 29, 2024

Language: Английский

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Efficacy of long‐term low carbohydrate diets for patients with type 2 diabetes: A systematic review and meta‐analysis

Journal of Diabetes Investigation, Journal Year: 2024, Volume and Issue: 15(10), P. 1410 - 1421

Published: July 24, 2024

Efficacy of long-term low-carbohydrate diets (LCD) to improve glycemic management for type 2 diabetes remains controversial. Thus, we investigated the association between LCD and control in individuals with diabetes.

Language: Английский

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Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas for Sight-Threatening Diabetic Retinopathy

Ophthalmology Retina, Journal Year: 2024, Volume and Issue: 8(10), P. 943 - 952

Published: May 11, 2024

Language: Английский

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The AMPK-SIRT1 Axis: Redefining type 2 diabetes mellitus management

Results in Chemistry, Journal Year: 2025, Volume and Issue: 14, P. 102139 - 102139

Published: Feb. 19, 2025

Language: Английский

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Maximising the potential of type 2 diabetes remission: scale up and sustainability considerations from the DiRECT-Aus implementation trial

Australian Journal of Primary Health, Journal Year: 2025, Volume and Issue: 31(2)

Published: March 3, 2025

Background Approximately 500 million people worldwide live with type 2 diabetes mellitus. The UK's 'Diabetes Remission Clinical Trial' (DiRECT) is a potential novel method for care. An Australian trial of DiRECT (DiRECT-Aus) showed that 56% participants achieved remission at 12months. We explored the experiences patients, clinicians and partners involved in DiRECT-Aus to ascertain acceptability feasibility DiRECT-Aus, as well factors influencing implementation, inform recommendations sustainable scale up into mainstream primary Methods This qualitative implementation research conducted within constructivist paradigm semi-structured interviews key stakeholders. Data analysis followed an inductive thematic approach, informed by Consolidated Framework Implementation Research. Results Patients (n =14), general practitioners =3), practice nurses =6), dietitians =7) =5) were interviewed. identified four core components are essential up. They were: (1) access very low-energy diet products; (2) high frequency contact dietitian; (3) dietitian's clinical knowledge patient-centred practice; (4) absence financial costs patients. Several additional could support suggested funding models described. Conclusions study concludes was acceptable feasible patients clinicians.

Language: Английский

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The Protective Effect of Curcumin on the Diabetic Uterus: Quantitative and Qualitative Evaluation

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102852 - 102852

Published: March 8, 2025

Language: Английский

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Role of γ-Aminobutyric Acid (GABA) as an Inhibitory Neurotransmitter in Diabetes Management: Mechanisms and Therapeutic Implications

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 399 - 399

Published: March 11, 2025

GABA (γ-Aminobutyric Acid), a well-established inhibitory neurotransmitter in the central nervous system, has garnered considerable interest for its potential role diabetes management, particularly due to presence pancreatic islets. This review aims explore therapeutic of management and mechanisms antidiabetic effects. Relevant studies were searched across databases such as PubMed ScienceDirect, applying strict eligibility criteria focused on administration methods diabetic models. The collective results showed that models resulted remarkable enhancements glucose insulin homeostasis, favorable modifications lipid profiles, amelioration dysfunctions neural, hepatic, renal, cardiac systems. findings from literature demonstrated GABAergic signaling within tissues can significantly contribute stimulation β cell proliferation through facilitation sustained trans-differentiation process, wherein glucagon-secreting α cells are converted into insulin-secreting β-like cells. In addition, activated trigger initiation PI3K/AKT pathway tissues, leading improved maintained homeostasis. further function hepatic promoting effects expression genes related gluconeogenesis lipogenesis. Moreover, may enhance gut microbiota diversity by attenuating inflammation, attributable anti-inflammatory immunomodulatory properties. Furthermore, neuroprotective play significant ameliorating neural disorders associated with facilitating substantial reduction neuronal apoptosis. conclusion, emerges promising candidate an agent; however, research is highly encouraged develop rigorously designed framework comprehensively identifies optimizes appropriate dosages intervention effectively managing combating diabetes.

Language: Английский

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Prise en charge périopératoire des patients diabétiques

Le Praticien en Anesthésie Réanimation, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

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The Association Between Health Belief Model Components and Self-Care Practices Among Black/African American Men with Type 2 Diabetes

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 414 - 414

Published: March 12, 2025

This study investigates the impact of Health Belief Model (HBM) constructs on self-care behaviors among Black/African American men with Type 2 Diabetes (T2D). A cross-sectional survey was conducted from February to June 2024, involving 1225 aged 21 years or older who self-reported a T2D diagnosis. The included HBM constructs, and measured using established scales. Statistical analyses, including multiple linear regression, were performed assess relationships between components practices, adjusted by demographic factors such as age, education, income. found that self-efficacy strongest predictor across all domains (β = 0.055, p < 0.001). Perceived susceptibility positively associated healthful eating 0.042, 0.038), glucose monitoring 0.117, 0.001), foot care 0.140, severity linked diet adherence 0.015, 0.001) 0.028, barriers negatively -0.047, However, perceived benefits did not significantly overall 0.001, 0.893). Self-efficacy, susceptibility, significant predictors T2D. In particular, interventions aimed at enhancing self-efficacy, addressing barriers, promoting awareness diabetes risks may improve management in this population.

Language: Английский

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