Meta-analysis of Cognitive Function Following Non-severe SARS-CoV-2 Infection

Neuropsychology Review, Год журнала: 2024, Номер unknown

Опубликована: Июнь 12, 2024

Язык: Английский

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Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Abstract Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies PCS. still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding

Язык: Английский

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Docking and Post-Processing of 1 Million Molecules from the CNCL Database in Search of SARS-CoV-2 Mpro Inhibitors

Lecture notes in computer science, Год журнала: 2025, Номер unknown, С. 47 - 58

Опубликована: Янв. 1, 2025

Язык: Английский

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Examining recovery trajectories of physical function, activity performance, cognitive and psychological functions, and health related quality of life in COVID-19 patients treated in ICU: a Swedish prospective cohort study

Disability and Rehabilitation, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Фев. 8, 2025

To investigate the recovery trajectories of physical function, activity performance, cognitive and psychological functions, health related quality life, as well potential interaction effects, in individuals with COVID-19 treated an intensive care unit (ICU). This prospective cohort study included patients confirmed infection, ICU. Clinical assessments self-ratings functioning, disability were performed > 1 month 12 months after discharge from hospital. Among 65 (mean age 56.6, SD 11) significant improvements function observed over time, although not reaching population norms. Cognition remained unchanged (MoCA median 27, IQR 4). At 12-month follow-up, limitations (RAND-36) found to be associated dyspnea (mMRC-Dyspnea), mental fatigue (MFI-20), walking endurance (6-minute walk test) (r2 0.509 p < 0.001). Role due was (MFI-20) pain 0.530 Despite functioning this group predominantly younger did reach These results highlight persistent impairments that may necessitate long-term healthcare interventions.

Язык: Английский

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Social Vulnerability and Long‐Term Cardiovascular Outcomes After COVID‐19 Hospitalization: An Analysis of the American Heart Association COVID‐19 Registry Linked With Medicare Claims Data

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Background Patients hospitalized with COVID‐19 from socioeconomically vulnerable communities are at risk for in‐hospital cardiovascular events. However, the association of socioeconomic vulnerability and outcomes after hospitalization is uncertain. Methods Results American Heart Association Cardiovascular Disease Registry hospitalizations between March 1, 2020, June 30, 2022, linked Medicare fee‐for‐service claims, were analyzed. We used Centers Control Prevention's Social Vulnerability Index to ascertain county‐level Medicare‐Medicaid dual eligibility patient‐level social vulnerability. evaluated a composite myocardial infarction, stroke, heart failure, venous thromboembolism, cardiogenic shock, cardiac arrest, death, following discharge, using Cox regression models. The study included 8565 patients (mean age 78 years, 50% female, 16% Black, 4% Hispanic, 25% eligible, 34% residing in most counties). counties, eligible patients, more likely be Black or have increased comorbidities. A total 3783 (52%) experienced outcome. found no vulnerable, compared least counties events (hazard ratio [HR], 0.97 [95% CI, 0.87–1.07]). Dual eligibility, nondual was associated (HR, 1.28 1.19–1.37]), which attenuated adjusting comorbidities 0.89–1.04]). Conclusions Among survivors hospitalization, events, explained by County‐level not observed postdischarge Findings suggest targeting public health efforts toward mitigate poor outcomes.

Язык: Английский

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Determination of both the expression and serum levels of epidermal growth factor and transforming growth factor β1 genes in COVID-19

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 21, 2025

We aimed to evaluate the effects of both expression and serum levels Epidermal growth factor (EGF) Transforming factor-β1 (TGF-β1) genes in patients with different degrees cellular damage as mild, moderate, severe, critical illness that can lead fibrosis caused by SARS-CoV-2. Totally 45 individuals (male: 21(46.67%); female: 24(53.33%)) COVID-19 infection were included this study. Four groups constituted mild (n = 16)], moderate 10), severe 9) according severity disease. Blood samples drawn from patients, all hemograms, EGF TGFβ1 gene expression, evaluated. The mean age was 57.311 ± 18.383 (min: 28, max: 94). Significant differences found among for PLT (χ2 9.955; p 0.019), CRP 7.693; 0.053), Ferritin 22.196; < 0.001), D-dimer 21.982; 0.000), LDH 21.807; 0.001) these parameters (exclude groups) increased depending on Additionally, significant detected 29.528; TGFB1 28.981; (that disease severity), 7.84; 0.049), 17.451; concentration decreased severity). This study statistically 2−ΔΔCt. 2−ΔΔCt EGF, values patient groups. As increased, while decreased. Perhaps will be useful managing pulmonary cases secondary COVID-19.

Язык: Английский

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Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study

The American Journal of Medicine, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Background Most working-age (18-64) adults have been infected with SARS-CoV-2, and some may developed post-COVID-19 condition (PCC). However, health-related quality of life (HRQOL) greater than 2 years following infection remains uncharacterized. Methods In this cross-sectional study, COVID-19 survivors from throughout British Columbia (BC), Canada, completed a questionnaire post-infection. PCC status was self-reported, HRQOL assessed using the EuroQol 5-dimension 5-level (EQ-5D-5L) instrument. We compared in those current PCC, recovered without history PCC. Iterative proportional fitting used to weight analyses be representative BC. Multivariable regression models were adjust for confounders. Results Of 1,135 analyzed participants, 19.2% had 27.6% Compared participants similar weighted mean EQ-5D health utility (adjusted difference -0.02 [95%CI -0.03, 0.00]), but lower -0.08 -0.12, -0.05]). more likely report problems mobility odds ratio (aOR) 6.00 2.88-12.52]), self-care (aOR 5.96 1.84-19.32]), usual activities 8.00 4.27-14.99]), pain/discomfort 4.28 2.46-7.48]), anxiety/depression 3.45 1.90-6.27]). Conclusions who survived COVID-19, is high among never or individuals ongoing symptoms are deficits multiple functional domains. These findings underscore importance implementing targeted healthcare interventions improve long-term

Язык: Английский

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Tackling persistent neurological symptoms in patients following acute COVID-19 infection: an update of the literature

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Дек. 23, 2024

Introduction The COVID-19 pandemic has taught myriad lessons and left several questions we are yet to comprehend. Initially, the scientific community was concerned with management of acute disease immunization. Once peak receded, it became clear that a proportion patients were far from fully recovered. Researchers started recognize those persisting symptoms as new entity termed 'Long COVID,' where neurological evident have major impact on quality life.

Язык: Английский

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Brief Outpatient Rehabilitation Program for Post–COVID-19 Condition

JAMA Network Open, Год журнала: 2024, Номер 7(12), С. e2450744 - e2450744

Опубликована: Дек. 19, 2024

Post-COVID-19 condition (PCC) is emerging as a common and debilitating with few treatment options.

Язык: Английский

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Rapid diagnosis and severity scale of post-COVID condition using advanced spectroscopy

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 328, С. 125474 - 125474

Опубликована: Ноя. 24, 2024

The COVID-19 pandemic has resulted in a persistent health challenge known as Post-COVID Condition (PCC), characterized by symptoms lasting at least three months after the initial SARS-CoV-2 infection and potentially persisting for several years. While studies on PCC using lipidomics proteomics have been conducted, these methods are costly time-consuming. comprehensive analysis of UV-VIS-NIR-MIR spectroscopy is explored here an alternative rapid cheap diagnosis quantification severity PCC. Blood samples from 65 patients, previously analyzed lipidomic proteomic studies, along with new were examined to develop model that quantifies based solely spectrophotometric data. Significant spectral variability was observed UV-VIS region, particularly between 297 600 nm, correlating strongly patient symptoms. Unsupervised clustering algorithms this region effectively differentiated asymptomatic symptomatic achieving Jaccard similarity score 0.667 when compared clinical symptom classifications. Comparative indicated captures clinically relevant biochemical information. results developed work quantify demonstrated robustness data, underscoring method's potential rapid, non-invasive, cost-effective diagnostic tool. This study highlights strengths spectroscopic techniques, suggesting their suitability widespread application diagnosing monitoring PCC, emphasizes need further refinement integration into healthcare practice, implementation portable devices.

Язык: Английский

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