Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 19, 2024
Abstract
Memory
consolidation
relies
in
part
on
the
reactivation
of
previous
experiences
during
sleep.
The
precise
interplay
sleep-related
oscillations
(slow
oscillations,
spindles
and
ripples)
is
thought
to
coordinate
information
flow
between
relevant
brain
areas,
with
ripples
mediating
memory
reactivation.
However,
humans
empirical
evidence
for
a
role
lacking.
Here,
we
investigated
relevance
sleep
specifically
human
using
targeted
Intracranial
electrophysiology
epilepsy
patients
scalp
EEG
healthy
participants
revealed
that
elevated
levels
slow
oscillation
-
spindle
activity
coincided
read-out
experimentally
induced
Importantly,
spindle-locked
recorded
intracranially
from
medial
temporal
lobe
were
found
be
correlated
identification
non-rapid
eye
movement
Our
findings
establish
as
key-oscillation
emphasize
importance
coordinated
cardinal
oscillations.
Flexible
behaviors
over
long
timescales
are
thought
to
engage
recurrent
neural
networks
in
deep
brain
regions,
which
experimentally
challenging
study.
In
insects,
circuit
dynamics
a
region
called
the
central
complex
(CX)
enable
directed
locomotion,
sleep,
and
context-
experience-dependent
spatial
navigation.
We
describe
first
complete
electron
microscopy-based
connectome
of
Cell,
Год журнала:
2023,
Номер
186(1), С. 178 - 193.e15
Опубликована: Янв. 1, 2023
The
hypothalamus
regulates
innate
social
behaviors,
including
mating
and
aggression.
These
behaviors
can
be
evoked
by
optogenetic
stimulation
of
specific
neuronal
subpopulations
within
MPOA
VMHvl,
respectively.
Here,
we
perform
dynamical
systems
modeling
population
activity
in
these
nuclei
during
behaviors.
In
unsupervised
analysis
identified
a
dominant
dimension
neural
with
large
time
constant
(>50
s),
generating
an
approximate
line
attractor
state
space.
Progression
the
trajectory
along
this
was
correlated
escalation
agonistic
behavior,
suggesting
that
it
may
encode
scalable
aggressiveness.
Consistent
this,
individual
differences
magnitude
integration
were
strongly
contrast,
attractors
not
observed
mating;
instead,
neurons
fast
dynamics
tuned
to
actions.
Thus,
different
hypothalamic
employ
distinct
codes
represent
similar
Nature Neuroscience,
Год журнала:
2023,
Номер
26(5), С. 765 - 773
Опубликована: Апрель 24, 2023
Abstract
Animals
generate
neural
representations
of
their
heading
direction.
Notably,
in
insects,
direction
is
topographically
represented
by
the
activity
neurons
central
complex.
Although
head
cells
have
been
found
vertebrates,
connectivity
that
endows
them
with
properties
unknown.
Using
volumetric
lightsheet
imaging,
we
find
a
topographical
representation
neuronal
network
zebrafish
anterior
hindbrain,
where
sinusoidal
bump
rotates
following
directional
swims
fish
and
otherwise
stable
over
many
seconds.
Electron
microscopy
reconstructions
show
that,
although
cell
bodies
are
located
dorsal
region,
these
arborize
interpeduncular
nucleus,
reciprocal
inhibitory
stabilizes
ring
attractor
encodes
heading.
These
resemble
those
fly
complex,
showing
similar
circuit
architecture
principles
may
underlie
across
animal
kingdom
paving
way
to
an
unprecedented
mechanistic
understanding
networks
vertebrates.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(3)
Опубликована: Янв. 10, 2024
The
brain
is
composed
of
complex
networks
interacting
neurons
that
express
considerable
heterogeneity
in
their
physiology
and
spiking
characteristics.
How
does
this
neural
influence
macroscopic
dynamics,
how
might
it
contribute
to
computation?
In
work,
we
use
a
mean-field
model
investigate
computation
heterogeneous
networks,
by
studying
the
cell
thresholds
affects
three
key
computational
functions
population:
gating,
encoding,
decoding
signals.
Our
results
suggest
serves
different
types.
inhibitory
interneurons,
varying
degree
spike
threshold
allows
them
gate
propagation
signals
reciprocally
coupled
excitatory
population.
Whereas
homogeneous
interneurons
impose
synchronized
dynamics
narrow
dynamic
repertoire
neurons,
act
as
an
offset
while
preserving
neuron
function.
Spike
also
controls
entrainment
properties
periodic
input,
thus
affecting
temporal
gating
synaptic
inputs.
Among
increases
dimensionality
improving
network’s
capacity
perform
tasks.
Conversely,
suffer
for
function
generation,
but
excel
at
encoding
via
multistable
regimes.
Drawing
from
these
findings,
propose
intra-cell-type
mechanism
sculpting
local
circuits
permitting
same
canonical
microcircuit
be
tuned
diverse
Neuron,
Год журнала:
2020,
Номер
107(5), С. 924 - 940.e18
Опубликована: Июль 17, 2020
Spatial
maps
in
the
brain
are
most
accurate
when
they
linked
to
external
sensory
cues.
Here,
we
show
that
compass
Drosophila
is
direction
of
wind.
Shifting
wind
rightward
rotates
as
if
fly
were
turning
leftward,
and
vice
versa.
We
describe
mechanisms
several
computations
integrate
information
into
compass.
First,
an
intensity-invariant
representation
computed
by
comparing
left-right
mechanosensory
signals.
Then,
signals
reformatted
reduce
coding
biases
inherent
peripheral
mechanics,
cues
brought
same
circular
coordinate
system
represents
visual
self-motion
Because
incorporates
both
cues,
it
should
enable
navigation
under
conditions
where
no
single
cue
consistently
reliable.
These
results
how
local
can
be
transformed
a
global,
multimodal,
abstract
space.
