Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 25(2), С. 279 - 308
Опубликована: Дек. 5, 2023
Abstract Adipose tissue, including white adipose tissue (WAT), brown (BAT), and beige is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates as heat for thermoregulation. Beige a hybrid form of that shares characteristics with BAT. Dysregulation metabolism linked to various disorders, obesity, type 2 diabetes, cardiovascular diseases, cancer, infertility. Both adipocytes secrete multiple molecules, such batokines, packaged extracellular vesicles or soluble signaling molecules play autocrine, paracrine, endocrine roles. A greater understanding the adipocyte secretome essential identifying novel molecular targets treating metabolic disorders. Additionally, microRNAs show crucial roles regulating differentiation function, highlighting their potential biomarkers The browning has emerged promising therapeutic approach obesity associated Many agents have been identified, nanotechnology-based drug delivery systems developed enhance efficacy. This review scrutinizes differences between white, brown, tissues, mechanisms involved development adipocytes, significant regulatory active different tissues. Finally, atherosclerosis, relationship cancer fertility crosstalk circadian system disorders are also investigated.
Язык: Английский
Процитировано
45
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2251 - 2251
Опубликована: Фев. 13, 2024
This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.
Язык: Английский
Процитировано
30
Nature Cell Biology, Год журнала: 2024, Номер 26(5), С. 674 - 686
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
19
Life Metabolism, Год журнала: 2024, Номер 3(2)
Опубликована: Янв. 20, 2024
In addition to their pivotal roles in energy storage and expenditure, adipose tissues play a crucial part the secretion of bioactive molecules, including peptides, lipids, metabolites, extracellular vesicles, response physiological stimulation metabolic stress. These secretory factors, through autocrine paracrine mechanisms, regulate various processes within tissues. include adipogenesis, glucose lipid metabolism, inflammation, adaptive thermogenesis, all which are essential for maintenance balance functionality tissue micro-environment. A subset these adipose-derived factors can enter circulation target distant appetite, cognitive function, insulin sensitivity, gluconeogenesis, cardiovascular remodeling, exercise capacity. this review, we highlight role signaling pathways modulating homeostasis. Furthermore, delve into alterations both content under pathological conditions, shedding light on potential pharmacological treatment strategies related diseases.
Язык: Английский
Процитировано
11
Nutrients, Год журнала: 2023, Номер 15(24), С. 5082 - 5082
Опубликована: Дек. 12, 2023
Endoplasmic reticulum (ER) stress plays a pivotal role in adipogenesis, which encompasses the differentiation of adipocytes and lipid accumulation. Sustained ER has potential to disrupt signaling unfolded protein response (UPR), thereby influencing adipogenesis. This comprehensive review illuminates molecular mechanisms that underpin interplay between We delve into dysregulation UPR pathways, namely, IRE1-XBP1, PERK ATF6 relation adipocyte differentiation, metabolism, tissue inflammation. Moreover, we scrutinize how impacts key adipogenic transcription factors such as proliferator-activated receptor γ (PPARγ) CCAAT-enhancer-binding proteins (C/EBPs) along with their interaction other pathways. The cellular ramifications include alterations adipokines, aged adipose also discuss roles chaperones cyclophilin A B play By shedding light on intricate relationship this paves way for devising innovative therapeutic interventions.
Язык: Английский
Процитировано
19
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Июнь 12, 2024
Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective this review to summarize analyze the on biological activities RES in disease prevention treatment, as well its metabolism bioavailability. It also discusses challenges clinical application future research directions. exhibits significant treatment many diseases. direction should focus improving bioavailability, conducting more trials determine effectiveness humans, investigating mechanism action. Once these been overcome, expected become an effective intervention.
Язык: Английский
Процитировано
9
Trends in Cell Biology, Год журнала: 2022, Номер 33(6), С. 517 - 529
Опубликована: Окт. 19, 2022
Язык: Английский
Процитировано
26
Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(33)
Опубликована: Авг. 7, 2023
Great progress has been made in identifying positive regulators that activate adipocyte thermogenesis, but negative regulatory signaling of thermogenesis remains poorly understood. Here, we found cardiotrophin-like cytokine factor 1 (CLCF1) led to loss brown fat identity, which impaired thermogenic capacity. CLCF1 levels decreased during stimulation were considerably increased obesity. Adipocyte-specific transgenic (CLCF1-ATG) mice showed energy expenditure and severe cold intolerance. Elevated triggered whitening adipose tissue by suppressing mitochondrial biogenesis. Mechanistically, bound activated ciliary neurotrophic receptor (CNTFR) augmented signal transducer activator transcription 3 (STAT3) signaling. STAT3 transcriptionally inhibited both peroxisome proliferator-activated receptor-γ coactivator (PGC) 1α 1β, thereafter restrained biogenesis adipocytes. Inhibition CNTFR or could diminish the inhibitory effects on thermogenesis. As a result, CLCF1-TG predisposed develop metabolic dysfunction even without external stress. Our findings revealed brake nonshivering suggested targeting this pathway be used restore activity systemic homeostasis
Язык: Английский
Процитировано
14
Biochemical Pharmacology, Год журнала: 2023, Номер 218, С. 115876 - 115876
Опубликована: Окт. 21, 2023
Язык: Английский
Процитировано
14
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(3), С. 167010 - 167010
Опубликована: Янв. 2, 2024
Язык: Английский
Процитировано
6