Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice DOI Creative Commons
Ruonan Zhou, Ziwei Zhu,

Ping-Yuan Xu

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 16, 2024

Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice. We construct macrophage-adipocyte co-culture system and demonstrate promotes adipocyte through inhibiting NLRP3 inflammasome activation macrophages. Moreover, clues acetylome analysis identify SIRT2 as potential drug target of rhein. further verify directly interacts with inhibits SIRT2-dependent way. Myeloid knockdown abrogates metabolic benefits mice induced Together, our findings elucidate macrophages regulating SIRT2, thus white during obesity. These uncover the molecular mechanism underlying anti-obesity effects rhein, suggest may become for treating

Language: Английский

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications DOI Creative Commons
Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 25(2), P. 279 - 308

Published: Dec. 5, 2023

Abstract Adipose tissue, including white adipose tissue (WAT), brown (BAT), and beige is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates as heat for thermoregulation. Beige a hybrid form of that shares characteristics with BAT. Dysregulation metabolism linked to various disorders, obesity, type 2 diabetes, cardiovascular diseases, cancer, infertility. Both adipocytes secrete multiple molecules, such batokines, packaged extracellular vesicles or soluble signaling molecules play autocrine, paracrine, endocrine roles. A greater understanding the adipocyte secretome essential identifying novel molecular targets treating metabolic disorders. Additionally, microRNAs show crucial roles regulating differentiation function, highlighting their potential biomarkers The browning has emerged promising therapeutic approach obesity associated Many agents have been identified, nanotechnology-based drug delivery systems developed enhance efficacy. This review scrutinizes differences between white, brown, tissues, mechanisms involved development adipocytes, significant regulatory active different tissues. Finally, atherosclerosis, relationship cancer fertility crosstalk circadian system disorders are also investigated.

Language: Английский

Citations

42
The Metabolic Syndrome, a Human Disease DOI Open Access
M. Alemany

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

Citations

30
Mitochondrial heterogeneity and adaptations to cellular needs DOI
Melia Granath-Panelo, Shingo Kajimura

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(5), P. 674 - 686

Published: May 1, 2024

Language: Английский

Citations

18
The secretory function of adipose tissues in metabolic regulation DOI Creative Commons
Yang Liu, Shuwen Qian, Yan Tang

et al.

Life Metabolism, Journal Year: 2024, Volume and Issue: 3(2)

Published: Jan. 20, 2024

In addition to their pivotal roles in energy storage and expenditure, adipose tissues play a crucial part the secretion of bioactive molecules, including peptides, lipids, metabolites, extracellular vesicles, response physiological stimulation metabolic stress. These secretory factors, through autocrine paracrine mechanisms, regulate various processes within tissues. include adipogenesis, glucose lipid metabolism, inflammation, adaptive thermogenesis, all which are essential for maintenance balance functionality tissue micro-environment. A subset these adipose-derived factors can enter circulation target distant appetite, cognitive function, insulin sensitivity, gluconeogenesis, cardiovascular remodeling, exercise capacity. this review, we highlight role signaling pathways modulating homeostasis. Furthermore, delve into alterations both content under pathological conditions, shedding light on potential pharmacological treatment strategies related diseases.

Language: Английский

Citations

11
Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated DOI Open Access

G.D. Kim,

Jiyoon Lee, Joohun Ha

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5082 - 5082

Published: Dec. 12, 2023

Endoplasmic reticulum (ER) stress plays a pivotal role in adipogenesis, which encompasses the differentiation of adipocytes and lipid accumulation. Sustained ER has potential to disrupt signaling unfolded protein response (UPR), thereby influencing adipogenesis. This comprehensive review illuminates molecular mechanisms that underpin interplay between We delve into dysregulation UPR pathways, namely, IRE1-XBP1, PERK ATF6 relation adipocyte differentiation, metabolism, tissue inflammation. Moreover, we scrutinize how impacts key adipogenic transcription factors such as proliferator-activated receptor γ (PPARγ) CCAAT-enhancer-binding proteins (C/EBPs) along with their interaction other pathways. The cellular ramifications include alterations adipokines, aged adipose also discuss roles chaperones cyclophilin A B play By shedding light on intricate relationship this paves way for devising innovative therapeutic interventions.

Language: Английский

Citations

19
Multidimensional biological activities of resveratrol and its prospects and challenges in the health field DOI Creative Commons

Xi Yu,

Yuanqiang Jia,

Feiyue Ren

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 12, 2024

Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective this review to summarize analyze the on biological activities RES in disease prevention treatment, as well its metabolism bioavailability. It also discusses challenges clinical application future research directions. exhibits significant treatment many diseases. direction should focus improving bioavailability, conducting more trials determine effectiveness humans, investigating mechanism action. Once these been overcome, expected become an effective intervention.

Language: Английский

Citations

6
Multifaceted mitochondrial quality control in brown adipose tissue DOI Creative Commons
Katia Aquilano, Beiyan Zhou, Jonathan R. Brestoff

et al.

Trends in Cell Biology, Journal Year: 2022, Volume and Issue: 33(6), P. 517 - 529

Published: Oct. 19, 2022

Language: Английский

Citations

26
CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes DOI Creative Commons
Meng Ding, Hongyu Xu,

Wei-Yu Zhou

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(33)

Published: Aug. 7, 2023

Great progress has been made in identifying positive regulators that activate adipocyte thermogenesis, but negative regulatory signaling of thermogenesis remains poorly understood. Here, we found cardiotrophin-like cytokine factor 1 (CLCF1) led to loss brown fat identity, which impaired thermogenic capacity. CLCF1 levels decreased during stimulation were considerably increased obesity. Adipocyte-specific transgenic (CLCF1-ATG) mice showed energy expenditure and severe cold intolerance. Elevated triggered whitening adipose tissue by suppressing mitochondrial biogenesis. Mechanistically, bound activated ciliary neurotrophic receptor (CNTFR) augmented signal transducer activator transcription 3 (STAT3) signaling. STAT3 transcriptionally inhibited both peroxisome proliferator-activated receptor-γ coactivator (PGC) 1α 1β, thereafter restrained biogenesis adipocytes. Inhibition CNTFR or could diminish the inhibitory effects on thermogenesis. As a result, CLCF1-TG predisposed develop metabolic dysfunction even without external stress. Our findings revealed brake nonshivering suggested targeting this pathway be used restore activity systemic homeostasis

Language: Английский

Citations

14
Methyltransferase-like 3 modifications of RNAs: Implications for the pathology in the endocrine system DOI Creative Commons
Xiaojuan Su, Yi Qu, Dezhi Mu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(3), P. 167010 - 167010

Published: Jan. 2, 2024

Language: Английский

Citations

6
Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis DOI Creative Commons
Neda Dadgar,

Christopher Sherry,

Jenna Zimmerman

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 30, 2024

Abstract Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with poor prognosis and limited treatment options. Recent work identifying high concentrations the cytokine interleukin-6 (IL-6) its soluble receptor (sIL-6-Rα) in peritoneal cavity patients PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides comprehensive overview current understanding role IL-6 development progression PC. We discuss mechansims by which may contribute to tumor dissemination, mesothelial adhesion invasion, stromal invasion proliferation, immune response modulation. Finally, we prospects for targeting PC, focusing on common sites origin, including ovarian, gastric, pancreatic, colorectal appendiceal cancer, mesothelioma.

Language: Английский

Citations

5