Hepatology Communications,
Год журнала:
2024,
Номер
8(4)
Опубликована: Март 29, 2024
Background:
Alcohol-associated
liver
disease
(ALD)
is
a
major
health
care
challenge
worldwide
with
limited
therapeutic
options.
Although
mesenchymal
stem/stromal
cells
(MSCs)
represent
newly
emerging
approach
to
treat
ALD,
thus
far,
there
have
been
extensive
efforts
try
and
enhance
their
efficacy,
including
genetically
engineering
MSCs.
FGF21,
an
endocrine
stress-responsive
hormone,
has
shown
regulate
energy
balance,
glucose,
lipid
metabolism
the
homing
of
MSCs
toward
injured
sites.
Therefore,
purpose
this
study
was
investigate
whether
that
overexpress
FGF21
(FGF21-MSCs)
improve
effect
in
treating
ALD.
Methods:
Human
umbilical
cord-derived
served
as
gene
delivery
vehicle
for
gene.
were
transduced
using
lentiviral
vectors
mediate
overexpression.
We
utilized
both
chronic
Lieber-DeCarli
Gao-binge
models
ethanol-induced
injury
observe
FGF21-MSCs.
Liver
phenotypically
evaluated
by
performing
biochemical
methods,
histology,
inflammatory
cytokine
levels.
Results:
Compared
alone,
administration
overexpressing
FGF21(FGF21-MSCs)
treatment
significantly
enhanced
ALD
mice,
indicated
alleviation
reduced
steatosis,
infiltration,
oxidative
stress,
hepatic
apoptosis,
promotion
regeneration.
Mechanistically,
could
facilitate
immunomodulatory
function
on
macrophages
setting
metabolic
commitment
phosphorylation,
which
enables
exhibit
anti-inflammatory
inclination.
Conclusions:
Our
data
elucidate
MSC
modification
may
help
exploration
effective
MSCs-based
cell
therapies
ACS Nano,
Год журнала:
2023,
Номер
18(1), С. 951 - 971
Опубликована: Дек. 26, 2023
Functional
remodeling
and
prolonged
anti-inflammatory
responses
are
both
vital
for
repairing
damage
in
the
cardiovascular
system.
Although
these
aspects
have
each
been
studied
extensively
alone,
attempts
to
fabricate
scaffolds
that
combine
effects
seen
limited
success.
In
this
study,
we
synthesized
salvianic
acid
A
(SA,
danshensu)
blocked
biodegradable
polyurethane
(PCHU-D)
enclosed
it
within
electrospun
nanofibers
synthesize
a
durable
immunomodulatory
nanofiber
niche
(DINN),
which
provided
sustained
SA
release
during
inflammation.
Given
its
excellent
processability,
mechanical
properties,
shape
memory
function,
developed
two
variants
of
DINN
as
vascular
heart
patches.
Both
exhibited
outstanding
therapeutic
Journal of Gastroenterology and Hepatology,
Год журнала:
2023,
Номер
38(8), С. 1233 - 1240
Опубликована: Июль 9, 2023
Abstract
Alcoholic
liver
disease
(ALD),
which
is
a
leading
cause
of
morbidity
and
mortality
worldwide,
covers
large
spectrum
injuries
ranging
from
simple
steatosis
to
steatohepatitis,
advanced
fibrosis,
cirrhosis,
hepatocellular
carcinoma.
The
pathogenesis
ALD
includes
genetic
epigenetic
alterations,
oxidative
stress,
acetaldehyde‐mediated
toxicity
cytokine
chemokine‐induced
inflammation,
metabolic
reprogramming,
immune
damage,
dysbiosis
the
gut
microbiota.
This
review
discusses
progress
in
molecular
mechanism
ALD,
could
provide
evidence
for
further
research
on
potential
therapeutic
strategies
targeting
these
pathways.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Июль 8, 2022
Diet
is
a
major
driver
of
the
structure
and
function
gut
microbiota,
which
influences
host
physiology.
Alcohol
abuse
can
induce
liver
disease
microbiota
dysbiosis.
Here,
we
aim
to
elucidate
whether
well-known
traditional
health
food
Goji
berry
targets
prevent
injury
induced
by
acute
alcohol
intake.
The
results
showed
that
supplementation
for
14
days
alleviated
as
indicated
lowering
serum
aspartate
aminotransferase,
alanine
pro-inflammatory
cytokines,
well
lipopolysaccharide
content
in
tissue.
maintained
integrity
epithelial
barrier
increased
levels
butyric
acid
cecum
contents.
Furthermore,
established
causal
relationship
between
protection
effects
with
help
antibiotics
treatment
fecal
transplantation
(FMT)
experiments.
Both
FMT-Goji
glutathione
(GSH)
selectively
enriched
acid-producing
bacterium
Akkermansia
Ruminococcaceae
using
16S
rRNA
gene
sequencing.
Metabolomics
analysis
samples
revealed
its
trained
could
regulate
retinoyl
β-glucuronide,
vanillic
acid,
increase
level
glutamate
pyroglutamic
are
involved
GSH
metabolism.
Our
study
highlights
communication
among
Goji,
homeostasis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(10), С. 8650 - 8650
Опубликована: Май 12, 2023
Alcohol
misuse,
directly
or
indirectly
as
a
result
of
its
metabolism,
negatively
impacts
most
tissues,
including
four
with
critical
roles
in
energy
metabolism
regulation:
the
liver,
pancreas,
adipose,
and
skeletal
muscle.
Mitochondria
have
long
been
studied
for
their
biosynthetic
roles,
such
ATP
synthesis
initiation
apoptosis.
However,
current
research
has
provided
evidence
that
mitochondria
participate
myriad
cellular
processes,
immune
activation,
nutrient
sensing
pancreatic
β-cells,
muscle
stem
progenitor
cell
differentiation.
The
literature
indicates
alcohol
impairs
mitochondrial
respiratory
capacity,
promoting
reactive
oxygen
species
(ROS)
generation
disrupting
dynamics,
leading
to
dysfunctional
accumulation.
As
discussed
this
review,
dyshomeostasis
emerges
at
nexus
between
alcohol-disrupted
tissue
injury.
Here,
we
highlight
link
focus
on
alcohol-mediated
disruption
immunometabolism,
which
refers
two
distinct,
yet
interrelated
processes.
Extrinsic
immunometabolism
involves
processes
whereby
cells
products
influence
and/or
metabolism.
Intrinsic
describes
fuel
utilization
bioenergetics
affect
intracellular
Alcohol-induced
dysregulation
cells,
contributing
This
review
will
present
state
literature,
describing
metabolic
immunometabolic
from
perspective.
