Abstract
Cellular
senescence
is
a
key
contributor
to
aging
and
aging-related
diseases,
but
its
metabolic
profiles
are
not
well
understood.
Here,
we
performed
systematic
analysis
of
the
features
four
types
cellular
(replication,
irradiation,
reactive
oxygen
species
[ROS],
oncogene)
in
12
cell
lines
using
genome-wide
modeling
meta-analysis.
We
discovered
that
replicative
ROS-induced
share
common
signature,
marked
by
decreased
lipid
metabolism
downregulated
mevalonate
pathway,
while
irradiation
oncogene-induced
exhibit
more
heterogeneity
divergence.
Our
knockout
simulations
showed
enhancing
administrating
for
instance,
could
reverse
alterations
associated
with
human
tissue
aging,
suggesting
potential
anti-aging
or
lifespan-extending
effect.
Indeed,
experiment
Caenorhabditis
elegans
significantly
increased
lifespan.
study
provides
new
insight
into
landscape
identifies
targets
interventions.
Cardiac
aging
constitutes
a
significant
risk
factor
for
cardiovascular
diseases
prevalent
among
the
elderly
population.
Urgent
attention
is
required
to
prioritize
preventive
and
management
strategies
age-related
conditions
safeguard
well-being
of
individuals.
In
response
this
critical
challenge,
Aging
Biomarker
Consortium
(ABC)
China
has
formulated
an
expert
consensus
on
cardiac
biomarkers.
This
draws
upon
latest
scientific
literature
clinical
expertise
provide
comprehensive
assessment
biomarkers
associated
with
aging.
Furthermore,
it
presents
standardized
methodology
characterizing
across
three
dimensions:
functional,
structural,
humoral.
The
functional
dimension
encompasses
broad
spectrum
markers
that
reflect
diastolic
systolic
functions,
sinus
node
pacing,
neuroendocrine
secretion,
coronary
microcirculation,
metabolism.
structural
domain
emphasizes
imaging
relevant
concentric
remodeling,
artery
calcification,
epicardial
fat
deposition.
humoral
aspect
underscores
various
systemic
(N)
heart-specific
(X)
markers,
including
endocrine
hormones,
cytokines,
other
plasma
metabolites.
ABC's
primary
objective
establish
robust
foundation
assessing
aging,
thereby
furnishing
dependable
reference
applications
future
research
endeavors.
aims
contribute
significantly
enhancement
health
overall
Cardiovascular Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
As
the
global
demographic
landscape
continues
to
shift
towards
an
aged
population,
so
does
medical
and
socioeconomic
burden
of
cardiovascular
diseases.
Indeed,
ageing
is
one
of,
if
not
the,
key
risk
factor
for
development
However,
there
are
currently
no
approved
therapeutics
that
primarily
target
molecular
cellular
mechanisms
underlying
process
itself.
In
this
review,
we
present
potential
emerging
anti-ageing
strategies,
including
epigenetic
rejuvenation,
metabolic
reprogramming,
autophagy
activation,
as
well
senolytic
anti-inflammatory
therapies,
in
delaying
or
reversing
age-related
disorders,
while
considering
sex
differences.
doing
so,
implicate
processes
pathogenesis
several
prevalent
diseases,
such
atherosclerosis,
hypertension,
various
types
cardiomyopathies
(including
its
hypertrophic,
ischemic,
dilated,
diabetic,
arrhythmogenic
forms)
heart
failure,
particularly
with
preserved
ejection
fraction.
Finally,
outline
future
challenges
steps
needed
implementation
these
novel
strategies
clinical
setting,
aim
challenging
long-held
notion
a
'nonmodifiable'
Journal of Cardiovascular Development and Disease,
Год журнала:
2023,
Номер
10(10), С. 439 - 439
Опубликована: Окт. 23, 2023
Cellular
senescence
(CS),
classically
considered
a
stable
cell
cycle
withdrawal,
is
hallmarked
by
progressive
decrease
in
growth,
differentiation,
and
biological
activities.
Senescent
cells
(SNCs)
display
complicated
senescence-associated
secretory
phenotype
(SASP),
encompassing
variety
of
pro-inflammatory
factors
that
exert
influence
on
the
biology
both
surrounding
tissue.
Among
global
mortality
causes,
cardiovascular
diseases
(CVDs)
stand
out,
significantly
impacting
living
quality
functional
abilities
patients.
Recent
data
suggest
accumulation
SNCs
aged
or
diseased
systems,
suggesting
their
potential
role
impairing
function.
CS
operates
as
double-edged
sword:
while
it
can
stimulate
restoration
organs
under
physiological
conditions,
also
participate
organ
tissue
dysfunction
pave
way
for
multiple
chronic
pathological
states.
This
review
explores
mechanisms
underlie
delves
into
distinctive
features
characterize
SNCs.
Furthermore,
we
describe
involvement
progression
CVDs.
Finally,
study
provides
summary
emerging
interventions
either
promote
suppress
discusses
therapeutic
Geriatrics,
Год журнала:
2024,
Номер
9(2), С. 45 - 45
Опубликована: Апрель 3, 2024
Multidrug-resistant
sepsis
(MDR)
is
a
pressing
concern
in
intensive
care
unit
(ICU)
settings,
specifically
among
geriatric
patients
who
experience
age-related
immune
system
changes
and
comorbidities.
The
aim
of
this
review
to
explore
the
clinical
impact
MDR
ICU
shed
light
on
healthcare
challenges
associated
with
its
management.
We
conducted
comprehensive
literature
search
using
National
Center
for
Biotechnology
Information
(NCBI)
Google
Scholar
engines.
Our
incorporated
keywords
such
as
"multidrug-resistant
sepsis"
OR
"MDR
sepsis",
"geriatric
patients"
"elderly
patients",
"complications",
"healthcare
burdens",
"diagnostic
challenges",
challenges"
"ICU
"geriatric/elderly
patients".
This
explores
specific
risk
factors
contributing
sepsis,
complexities
diagnostic
challenges,
burden
faced
by
elderly
patients.
Notably,
population
bears
higher
(57.5%),
influenced
various
factors,
including
comorbidities,
immunosuppression,
changes,
resource-limited
settings.
Furthermore,
imposes
significant
economic
systems,
annual
costs
exceeding
$27
billion
USA.
These
findings
underscore
urgency
addressing
need
tailored
interventions
improve
outcomes
reduce
costs.
