Metabolites,
Год журнала:
2023,
Номер
13(5), С. 655 - 655
Опубликована: Май 13, 2023
The
elderly
have
higher
concentrations
of
advanced
glycation
end-products
(AGEs).
AGEs
are
considered
risk
factors
that
accelerate
aging
and
cause
diabetic
nephropathy.
effects
on
renal
function
in
the
remain
to
be
clarified.
This
study
aimed
explore
role
decline
protective
effect
resveratrol,
a
stilbenoid
polyphenol,
comparing
it
with
aminoguanidine
(an
inhibitor).
A
D-galactose-induced
mouse
model
was
used
process
aging.
mice
were
administered
D-galactose
subcutaneously
for
eight
weeks
presence
or
absence
orally
resveratrol.
results
showed
serum
levels
markers
BUN,
creatinine,
cystatin
C
significantly
increased
after
administration
D-galactose,
this
outcome
could
reversed
by
treatment
protein
expression
apoptosis,
fibrosis,
aging-related
indicators
kidneys
increased,
which
also
These
findings
suggest
resveratrol
alleviate
AGEs-related
dysfunction
through
improvement
cellular
senescence,
fibrosis
mice.
Life,
Год журнала:
2023,
Номер
13(2), С. 539 - 539
Опубликована: Фев. 15, 2023
Diabetic
Nephropathy
(DN)
is
a
serious
complication
of
type
I
and
II
diabetes.
It
develops
from
the
initial
microproteinuria
to
end-stage
renal
failure.
The
main
initiator
for
DN
chronic
hyperglycemia.
Hyperglycemia
(HG)
can
stimulate
resident
non-resident
cells
produce
humoral
mediators
cytokines
that
lead
functional
phenotypic
changes
in
tissues,
interference
with
cell
growth,
interacting
proteins,
advanced
glycation
end
products
(AGEs),
etc.,
ultimately
resulting
glomerular
tubular
damage
onset
kidney
disease.
Therefore,
poor
blood
glucose
control
particularly
important
risk
factor
development
DN.
In
this
paper,
types
mechanisms
are
classified
summarized
by
reviewing
related
literature
concerning
effect
hyperglycemia
on
At
cellular
level,
we
summarize
effects
This
expected
provide
therapeutic
ideas
inspiration
further
studies
treatment
patients
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Introduction
Diabetic
nephropathy
(DN),
distinguished
by
detrimental
changes
in
the
renal
glomeruli,
is
regarded
as
leading
cause
of
death
from
end-stage
disease
among
diabetics.
Cellular
senescence
plays
a
paramount
role,
profoundly
affecting
onset
and
progression
chronic
kidney
(CKD)
acute
injuries.
This
study
was
designed
to
delve
deeply
into
pathological
mechanisms
between
glomerulus-associated
DN
cellular
senescence.
Methods
Glomerulus-associated
datasets
senescence-related
genes
were
acquired
Gene
Expression
Omnibus
(GEO)
CellAge
database
respectively.
By
integrating
bioinformatics
machine
learning
methodologies
including
LASSO
regression
analysis
Random
Forest,
we
screened
out
four
signature
genes.
The
receiver
operating
characteristic
(ROC)
curve
performed
evaluate
diagnostic
performance
selected
Rigorous
experimental
validations
subsequently
conducted
mouse
model
corroborate
identification
three
genes,
namely
LOX,
FOXD1
GJA1.
Molecular
docking
with
chlorogenic
acids
(CGA)
further
established
not
only
validate
GJA1
markers
but
also
reveal
their
potential
therapeutic
effects.
Results
discussion
In
conclusion,
our
findings
pinpointed
on
basis
These
could
predict
an
increased
risk
present
promising
targets,
potentially
ushering
innovative
treatments
for
elderly
population.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(2), С. 956 - 956
Опубликована: Янв. 19, 2021
Klotho
was
initially
introduced
as
an
antiaging
molecule.
deficiency
significantly
reduces
lifespan,
and
its
overexpression
extends
it
protects
against
various
pathological
phenotypes,
especially
renal
disease.
It
shown
to
regulate
phosphate
calcium
metabolism,
protect
oxidative
stress,
downregulate
apoptosis,
have
antiinflammatory
antifibrotic
properties.
The
course
of
diabetes
mellitus
diabetic
nephropathy
resembles
premature
cellular
senescence
causes
the
activation
proinflammatory
profibrotic
processes.
exert
many
beneficial
effects
in
these
disorders.
expression
protein
is
downregulated
early
stages
inflammation
by
factors.
Therefore,
therapeutic
are
diminished
this
disorder.
Significantly
lower
urine
levels
may
serve
biomarker
involvement
mellitus.
Recombinant
administration
immunotherapeutic
potential
for
treatment
both
nephropathy.
current
manuscript
aims
characterize
immunopathologies
occurring
nephropathy,
tries
match
them
with
actions
Klotho.
also
gives
reasons
be
used
diagnostics
immunotherapy
Cellular
senescence
is
a
cell
fate
that
occurs
in
response
to
numerous
types
of
stress
and
can
promote
tissue
repair
or
drive
inflammation
disruption
homeostasis
depending
on
the
context.
Aging
obesity
lead
an
increase
senescent
burden
multiple
organs.
Senescent
cells
release
myriad
senescence-associated
secretory
phenotype
factors
directly
mediate
pancreatic
β-cell
dysfunction,
adipose
insulin
resistance
peripheral
tissues,
which
onset
type
II
diabetes
mellitus.
In
addition,
hyperglycemia
metabolic
changes
seen
cellular
senescence.
Diabetes-induced
contributes
various
diabetic
complications.
Thus,
both
cause
consequence
This
review
summarizes
recent
studies
link
between
aging,
obesity,
diabetes,
focusing
role
disease
processes.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Авг. 11, 2023
Diabetic
kidney
disease
(DKD)
is
the
most
important
microvascular
complication
of
diabetes
and
leading
cause
end-stage
renal
(ESRD)
worldwide.
The
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT)
signaling
pathway,
which
out
balance
in
context
DKD,
acts
through
a
range
metabolism-related
cytokines
hormones.
JAK/STAT
primary
node
progression
DKD.
latest
research
on
helps
determine
role
this
pathway
factors
associated
with
DKD
progression.
These
include
renin–angiotensin
system
(RAS),
fibrosis,
immunity,
inflammation,
aging,
autophagy,
EMT.
This
review
epitomizes
progress
understanding
complicated
explanation
etiologies
discusses
whether
it
can
be
potential
target
for
treating
It
further
summarizes
inhibitors,
natural
products,
other
drugs
that
are
promising
how
these
inhibitors
alleviate
to
explore
possible
will
contribute
formulating
effective
treatment
strategies
near
future.
Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Янв. 28, 2024
Abstract
D-ribose,
an
ubiquitous
pentose
compound
found
in
all
living
cells,
serves
as
a
vital
constituent
of
numerous
essential
biomolecules,
including
RNA,
nucleotides,
and
riboflavin.
It
plays
crucial
role
various
fundamental
life
processes.
Within
the
cellular
milieu,
exogenously
supplied
D-ribose
can
undergo
phosphorylation
to
yield
ribose-5-phosphate
(R-5-P).
This
R-5-P
dual
purpose:
it
not
only
contributes
adenosine
triphosphate
(ATP)
production
through
nonoxidative
phase
phosphate
pathway
(PPP)
but
also
participates
nucleotide
synthesis.
Consequently,
is
employed
both
therapeutic
agent
for
enhancing
cardiac
function
heart
failure
patients
remedy
post-exercise
fatigue.
Nevertheless,
recent
clinical
studies
have
suggested
potential
link
between
metabolic
disturbances
type
2
diabetes
mellitus
(T2DM)
along
with
its
associated
complications.
Additionally,
certain
vitro
experiments
indicated
that
exogenous
exposure
could
trigger
apoptosis
specific
cell
lines.
article
comprehensively
reviews
current
advancements
D-ribose’s
digestion,
absorption,
transmembrane
transport,
intracellular
pathways,
impact
on
behaviour,
elevated
levels
mellitus.
identifies
areas
requiring
further
investigation.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(2), С. 348 - 348
Опубликована: Янв. 8, 2024
Diabetes
mellitus
(DM)
and
chronic
kidney
disease
(CKD)
are
common
in
middle
aged
older
adult
individuals.
DM
may
accelerate
the
aging
process,
age-related
declines
estimated
glomerular
filtration
rate
(eGFR)
can
pose
a
challenge
to
diagnosing
diabetic
(DKD)
using
standard
diagnostic
criteria
especially
with
absence
of
severe
albuminuria
among
adults.
In
presence
CKD
DM,
patients
need
multidisciplinary
care
due
susceptibility
various
health
issues,
e.g.,
cognitive
decline,
auditory
or
visual
impairment,
comorbidities,
complex
medical
regimens,
increased
sensitivity
medication
adverse
effects.
As
result,
it
be
challenging
apply
recent
therapeutic
advancements
for
general
population
We
review
evidence
that
benefits
from
these
newer
therapies
equally
younger
diabetes
type
2
propose
comprehensive
management.
This
framework
will
address
nonpharmacological
measures
pharmacological
management
renin
angiotensin
system
inhibitors
(RASi),
sodium
glucose
co-transporter
(SGLT2i),
non-steroidal
mineralocorticoids
receptor
antagonists
(MRAs),
glucagon
like
peptide
1
agonists
(GLP1-RAs).
Comprehensive physiology,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 1, 2025
ABSTRACT
Humans
are
perhaps
evolutionarily
engineered
to
get
deeply
addicted
sugar,
as
it
not
only
provides
energy
but
also
helps
in
storing
fats,
which
survival
during
starvation.
Additionally,
sugars
(glucose
and
fructose)
stimulate
the
feel‐good
factor,
they
trigger
secretion
of
serotonin
dopamine
brain,
associated
with
reward
sensation,
uplifting
mood
general.
However,
when
consumed
excess,
contributes
imbalance,
weight
gain,
obesity,
leading
onset
a
complex
metabolic
disorder,
generally
referred
diabetes.
Type
2
diabetes
mellitus
(T2DM)
is
one
most
prevalent
forms
diabetes,
nearly
affecting
all
age
groups.
T2DM
clinically
diagnosed
cardinal
sign
chronic
hyperglycemia
(excessive
sugar
blood).
Chronic
hyperglycemia,
coupled
dysfunctions
pancreatic
β‐cells,
insulin
resistance,
immune
inflammation,
further
exacerbate
pathology
T2DM.
Uncontrolled
T2DM,
major
public
health
concern,
significantly
toward
progression
several
micro‐
macrovascular
diseases,
such
diabetic
retinopathy,
nephropathy,
neuropathy,
atherosclerosis,
cardiovascular
including
cancer.
The
current
review
discusses
epidemiology,
causative
factors,
pathophysiology,
comorbidities,
existing
emerging
therapies
related
It
future
roadmap
for
alternative
drug
discovery
management
