The Mechanism of Hyperglycemia-Induced Renal Cell Injury in Diabetic Nephropathy Disease: An Update

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 539 - 539

Published: Feb. 15, 2023

Diabetic Nephropathy (DN) is a serious complication of type I and II diabetes. It develops from the initial microproteinuria to end-stage renal failure. The main initiator for DN chronic hyperglycemia. Hyperglycemia (HG) can stimulate resident non-resident cells produce humoral mediators cytokines that lead functional phenotypic changes in tissues, interference with cell growth, interacting proteins, advanced glycation end products (AGEs), etc., ultimately resulting glomerular tubular damage onset kidney disease. Therefore, poor blood glucose control particularly important risk factor development DN. In this paper, types mechanisms are classified summarized by reviewing related literature concerning effect hyperglycemia on At cellular level, we summarize effects This expected provide therapeutic ideas inspiration further studies treatment patients

Language: Английский

---

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Introduction Diabetic nephropathy (DN), distinguished by detrimental changes in the renal glomeruli, is regarded as leading cause of death from end-stage disease among diabetics. Cellular senescence plays a paramount role, profoundly affecting onset and progression chronic kidney (CKD) acute injuries. This study was designed to delve deeply into pathological mechanisms between glomerulus-associated DN cellular senescence. Methods Glomerulus-associated datasets senescence-related genes were acquired Gene Expression Omnibus (GEO) CellAge database respectively. By integrating bioinformatics machine learning methodologies including LASSO regression analysis Random Forest, we screened out four signature genes. The receiver operating characteristic (ROC) curve performed evaluate diagnostic performance selected Rigorous experimental validations subsequently conducted mouse model corroborate identification three genes, namely LOX, FOXD1 GJA1. Molecular docking with chlorogenic acids (CGA) further established not only validate GJA1 markers but also reveal their potential therapeutic effects. Results discussion In conclusion, our findings pinpointed on basis These could predict an increased risk present promising targets, potentially ushering innovative treatments for elderly population.

Language: Английский

---

High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux

Human Cell, Journal Year: 2025, Volume and Issue: 38(2)

Published: Jan. 10, 2025

Language: Английский

---

Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(2), P. 956 - 956

Published: Jan. 19, 2021

Klotho was initially introduced as an antiaging molecule. deficiency significantly reduces lifespan, and its overexpression extends it protects against various pathological phenotypes, especially renal disease. It shown to regulate phosphate calcium metabolism, protect oxidative stress, downregulate apoptosis, have antiinflammatory antifibrotic properties. The course of diabetes mellitus diabetic nephropathy resembles premature cellular senescence causes the activation proinflammatory profibrotic processes. exert many beneficial effects in these disorders. expression protein is downregulated early stages inflammation by factors. Therefore, therapeutic are diminished this disorder. Significantly lower urine levels may serve biomarker involvement mellitus. Recombinant administration immunotherapeutic potential for treatment both nephropathy. current manuscript aims characterize immunopathologies occurring nephropathy, tries match them with actions Klotho. also gives reasons be used diagnostics immunotherapy

Language: Английский

---

Role of Cellular Senescence in Type II Diabetes

Endocrinology, Journal Year: 2021, Volume and Issue: 162(10)

Published: Aug. 7, 2021

Cellular senescence is a cell fate that occurs in response to numerous types of stress and can promote tissue repair or drive inflammation disruption homeostasis depending on the context. Aging obesity lead an increase senescent burden multiple organs. Senescent cells release myriad senescence-associated secretory phenotype factors directly mediate pancreatic β-cell dysfunction, adipose insulin resistance peripheral tissues, which onset type II diabetes mellitus. In addition, hyperglycemia metabolic changes seen cellular senescence. Diabetes-induced contributes various diabetic complications. Thus, both cause consequence This review summarizes recent studies link between aging, obesity, diabetes, focusing role disease processes.

Language: Английский

---

Cardiometabolic index is associated with urinary albumin excretion and renal function in aged person over 60: Data from NHANES 2011–2018

International Journal of Cardiology, Journal Year: 2023, Volume and Issue: 384, P. 76 - 81

Published: April 12, 2023

Language: Английский

---

JAK/STAT signaling in diabetic kidney disease

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 11, 2023

Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and leading cause end-stage renal (ESRD) worldwide. The Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, which out balance in context DKD, acts through a range metabolism-related cytokines hormones. JAK/STAT primary node progression DKD. latest research on helps determine role this pathway factors associated with DKD progression. These include renin–angiotensin system (RAS), fibrosis, immunity, inflammation, aging, autophagy, EMT. This review epitomizes progress understanding complicated explanation etiologies discusses whether it can be potential target for treating It further summarizes inhibitors, natural products, other drugs that are promising how these inhibitors alleviate to explore possible will contribute formulating effective treatment strategies near future.

Language: Английский

---

D-ribose metabolic disorder and diabetes mellitus

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Jan. 28, 2024

Abstract D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays crucial role various fundamental life processes. Within the cellular milieu, exogenously supplied D-ribose can undergo phosphorylation to yield ribose-5-phosphate (R-5-P). This R-5-P dual purpose: it not only contributes adenosine triphosphate (ATP) production through nonoxidative phase phosphate pathway (PPP) but also participates nucleotide synthesis. Consequently, is employed both therapeutic agent for enhancing cardiac function heart failure patients remedy post-exercise fatigue. Nevertheless, recent clinical studies have suggested potential link between metabolic disturbances type 2 diabetes mellitus (T2DM) along with its associated complications. Additionally, certain vitro experiments indicated that exogenous exposure could trigger apoptosis specific cell lines. article comprehensively reviews current advancements D-ribose’s digestion, absorption, transmembrane transport, intracellular pathways, impact on behaviour, elevated levels mellitus. identifies areas requiring further investigation.

Language: Английский

---

Chronic Kidney Disease in the Older Adult Patient with Diabetes

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 348 - 348

Published: Jan. 8, 2024

Diabetes mellitus (DM) and chronic kidney disease (CKD) are common in middle aged older adult individuals. DM may accelerate the aging process, age-related declines estimated glomerular filtration rate (eGFR) can pose a challenge to diagnosing diabetic (DKD) using standard diagnostic criteria especially with absence of severe albuminuria among adults. In presence CKD DM, patients need multidisciplinary care due susceptibility various health issues, e.g., cognitive decline, auditory or visual impairment, comorbidities, complex medical regimens, increased sensitivity medication adverse effects. As result, it be challenging apply recent therapeutic advancements for general population We review evidence that benefits from these newer therapies equally younger diabetes type 2 propose comprehensive management. This framework will address nonpharmacological measures pharmacological management renin angiotensin system inhibitors (RASi), sodium glucose co-transporter (SGLT2i), non-steroidal mineralocorticoids receptor antagonists (MRAs), glucagon like peptide 1 agonists (GLP1-RAs).

Language: Английский

---

Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management

Language: Английский

---