Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 23(7), С. 499 - 515

Опубликована: Фев. 21, 2022

Язык: Английский

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The sirtuin family in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 29, 2022

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, involved numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles members SIRT family health disease conditions. Notably, this protein plays a variety important cellular biology such as inflammation, metabolism, oxidative stress, apoptosis, etc., thus, it is considered potential therapeutic target for different kinds pathologies including cancer, cardiovascular disease, respiratory other Moreover, identification modulators exploring functions these prompted increased efforts discover new small molecules, which can modify activity. Furthermore, several randomized controlled trials indicated that interventions might affect expression human samples, supplementation diverse impact on physiological function participants. In review, we introduce history structure family, discuss molecular mechanisms elaborate regulatory SIRTs summarize inhibitors activators, review related clinical studies.

Язык: Английский

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Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation

Science Advances, Год журнала: 2021, Номер 7(35)

Опубликована: Авг. 27, 2021

Sustained release of oxygen accelerates diabetic wound healing by regulating epithelialization, angiogenesis, and inflammation.

Язык: Английский

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Quality control of the mitochondrion

Developmental Cell, Год журнала: 2021, Номер 56(7), С. 881 - 905

Опубликована: Март 7, 2021

Язык: Английский

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Mitochondrial dysfunction in metabolic syndrome

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2020, Номер 1866(10), С. 165838 - 165838

Опубликована: Май 16, 2020

Язык: Английский

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The Role of Oxidative Stress in Parkinson’s Disease

Antioxidants, Год журнала: 2020, Номер 9(7), С. 597 - 597

Опубликована: Июль 8, 2020

Parkinson's disease (PD) is caused by progressive neurodegeneration of dopaminergic (DAergic) neurons with abnormal accumulation α-synuclein in substantia nigra (SN). Studies have suggested the potential involvement dopamine, iron, calcium, mitochondria and neuroinflammation contributing to overwhelmed oxidative stress PD. Function studies on PD-causative mutations SNCA, PRKN, PINK1, DJ-1, LRRK2, FBXO7 ATP13A2 further indicate role pathogenesis Therefore, it reasonable that molecules involved stress, such as coenzyme Q10, uric acid, 8-hydroxy-2'-deoxyguanosin, homocysteine, retinoic acid/carotenes, vitamin E, glutathione peroxidase, superoxide dismutase, xanthine oxidase products lipid peroxidation, could be candidate biomarkers for Applications antioxidants modulate a strategy treating Although number antioxidants, creatine, pioglitazone, melatonin desferrioxamine, been tested clinical trials, none them demonstrated conclusive evidence ameliorate PD patients. Difficulties may long-standing progression neurodegeneration, lack premotor stage inadequate drug delivery across blood-brain barrier. Solutions these challenges will warranted future novel antioxidative treatment

Язык: Английский

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Understanding mechanisms of antioxidant action in health and disease

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(1), С. 13 - 33

Опубликована: Сен. 15, 2023

Язык: Английский

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Mitochondria as a Cellular Hub in Infection and Inflammation

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11338 - 11338

Опубликована: Окт. 20, 2021

Mitochondria are the energy center of cell. They found in cell cytoplasm as dynamic networks where they adapt production based on cell’s needs. also at proinflammatory response and have essential roles against pathogenic infections. a major site for Reactive Oxygen Species (ROS; or free radicals), which to fight infection. However, excessive uncontrolled can become deleterious cell, leading mitochondrial tissue damage. Pathogens exploit role mitochondria during infection by affecting oxidative phosphorylation mechanism (OXPHOS), network disrupting communication between nucleus mitochondria. The these biological processes makes organelle good targets development therapeutic strategies. In this review, we presented summary endosymbiotic origin their involvement pathogen response, well potential promising infectious diseases chronic inflammatory diseases.

Язык: Английский

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Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective

Antioxidants, Год журнала: 2022, Номер 11(7), С. 1394 - 1394

Опубликована: Июль 19, 2022

Macrophage polarization refers to the process by which macrophages can produce two distinct functional phenotypes: M1 or M2. The balance between both strongly affects progression of inflammatory disorders. Here, we review how redox signals regulate macrophage and reprogramming during acute inflammation. In M1, augment NADPH oxidase isoform 2 (NOX2), inducible nitric oxide synthase (iNOS), synaptotagmin-binding cytoplasmic RNA interacting protein (SYNCRIP), tumor necrosis factor receptor-associated 6 increase oxygen nitrogen reactive species, triggers response, phagocytosis, cytotoxicity. M2, down-regulate NOX2, iNOS, SYNCRIP, and/or up-regulate arginase superoxide dismutase type 1, counteract oxidative nitrosative stress, favor anti-inflammatory tissue repair responses. M2 exhibit different metabolic profiles, are tightly regulated mechanisms. Oxidative stress sustain phenotype activating glycolysis lipid biosynthesis, but inhibiting tricarboxylic acid cycle phosphorylation. This profile is reversed in because changes state. Therefore, new therapies based on mechanisms have emerged treat inflammation with positive results, highlights relevance signaling as a master regulator reprogramming.

Язык: Английский

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PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response

Antioxidants, Год журнала: 2023, Номер 12(5), С. 1075 - 1075

Опубликована: Май 10, 2023

Mitochondria play a major role in ROS production and defense during their life cycle. The transcriptional activator PGC-1α is key player the homeostasis of energy metabolism therefore closely linked to mitochondrial function. responds environmental intracellular conditions regulated by SIRT1/3, TFAM, AMPK, which are also important regulators biogenesis In this review, we highlight functions regulatory mechanisms within framework, with focus on its involvement lifecycle metabolism. As an example, show scavenging under inflammatory conditions. Interestingly, stress response factor NF-κB, regulates immune response, reciprocally regulated. During inflammation, NF-κB reduces expression activity. Low activity leads downregulation antioxidant target genes resulting oxidative stress. Additionally, low levels concomitant promote activity, exacerbates response.

Язык: Английский

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