Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

Advanced Materials, Год журнала: 2022, Номер 34(29)

Опубликована: Май 16, 2022

M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds can fail the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise clinical practice of wound healing. However, current hydrogels always needed for complex interventions high-cost treatments, such as cytokines cell therapies. In this study, a novel glycyrrhizic acid (GA)-based hybrid dressing intrinsic properties is developed to promote rapid This consists interpenetrating polymer networks composed inorganic Zn2+ -induced self-assembled GA photo-crosslinked methyl acrylated silk fibroin (SF), realizing both excellent injectability mechanical strength. Notably, SF/GA/Zn regulate responses inflammatory microenvironment, circumventing use any additives. The immunomodulatory be harnessed safe efficient therapeutics that accelerate three phases repair serve promising management wounds.

Язык: Английский

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Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(5), С. 7486 - 7502

Опубликована: Май 9, 2022

Hypoxia, excessive reactive oxygen species (ROS), impaired angiogenesis, lasting inflammation, and bacterial infection, are key problems impeding diabetic wound healing. Particularly, controllable release ROS scavenging capacities critical during the healing process. Here, an injectable hydrogel based on hyaluronic acid-graft-dopamine (HA-DA) polydopamine (PDA) coated Ti3C2 MXene nanosheets is developed catalytically cross-linked by oxyhemoglobin/hydrogen (HbO2/H2O2) system combined with mild photothermal stimulation for HbO2 not only acts as a horseradish peroxidase-like to catalyze formation but also carrier controllably when activated heat produced from near-infrared (NIR) irradiation. Specifically, can provide repeatedly binding in air NIR off. The stable photoresponsive heating behavior of ensures repeatable release. Additionally, artificial nonenzymatic antioxidant proposed scavenge nitrogen including H2O2, O2•-, •OH, keeping intracellular redox homeostasis alleviating oxidative stress, eradicate bacteria avoid infection. antibacterial abilities further improved PDA coating, which promotes cross-linking into network hydrogel. HA-DA molecules endow capacity regulate macrophage polarization M1 M2 achieve anti-inflammation. More importantly, MXene-anchored multifunctions tissue adhesion, self-healing, injectability, hemostasis, stimulation, greatly human umbilical vein endothelial cell proliferation migration notably facilitates infected

Язык: Английский

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All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor

Small, Год журнала: 2021, Номер 18(1)

Опубликована: Ноя. 17, 2021

Abstract The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic characterized by multiple drug‐resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, novel situ injectable HA@MnO 2 /FGF‐2/Exos hydrogel is introduced for improving wound healing. Through simple local injection, this able form protective barrier covering wound, providing rapid hemostasis long‐term antibacterial protection. MnO /ε‐PL nanosheet catalyze excess H O produced converting it , thus not only eliminating harmful effects but also Moreover, release M2‐derived Exosomes (M2 Exos) FGF‐2 growth factor stimulates angiogenesis epithelization, respectively. These vivo vitro results demonstrate accelerated healing use hydrogel, presenting viable strategy repair.

Язык: Английский

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A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Advanced Materials, Год журнала: 2023, Номер 35(19)

Опубликована: Фев. 22, 2023

Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for later situ local injections cover wounds long-termly accelerated healing via synergistic effect magnesium ions (Mg2+ ) engineered small extracellular vesicles (sEVs). The self-healing bio-adhesive properties make it ideal physical barrier At inflammation stage, formulation recruit bone marrow-derived mesenchymal stem cells sites stimulate them toward neurogenic differentiation, while providing immune microenvironment macrophage reprogramming. proliferation stage repair, robust occurs newly differentiated neural released Mg2+ , allowing regenerative take place at site. provides novel platform combined DW therapy.

Язык: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Год журнала: 2022, Номер 10(2)

Опубликована: Ноя. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Язык: Английский

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Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(51), С. 23438 - 23447

Опубликована: Дек. 13, 2022

Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in the primary difference between normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) healing of rats through integrating metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species modulate oxidative stress microenvironment wounds, leads natural transition from proliferation phase. Impressively, efficacy one-time-applied was comparable that human epidermal growth factor Gel, widely used drug various treatments. Such effective, safe, convenient meet complex demands.

Язык: Английский

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Smart bioadhesives for wound healing and closure

Bioactive Materials, Год журнала: 2022, Номер 19, С. 360 - 375

Опубликована: Апрель 26, 2022

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, on-demand treatment capabilities. Bioadhesives bio-inspired structures chemicals have shown unprecedented adhesion strengths, as well tunable optical, electrical, bio-dissolvable properties. Accelerated been achieved via directly released growth factors, material or drug-induced host immune responses, delivery curative cells. Most recently, integration biosensing modules units in a closed-loop system yielded bioadhesives, allowing sensing physiological conditions (e.g., pH, temperature, uric acid, glucose, cytokine) iterative feedback drastically enhanced, stage-specific by triggering drug to avoid infection prolonged inflammation. Despite advances burgeoning field, challenges still exist design fabrication integrated systems, particularly chronic wounds, presenting significant opportunities future next-generation materials systems.

Язык: Английский

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Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair

Bioactive Materials, Год журнала: 2023, Номер 24, С. 477 - 496

Опубликована: Янв. 9, 2023

Large bone defects resulting from fractures and disease are a major clinical challenge, being often unable to heal spontaneously by the body's repair mechanisms. Lines of evidence have shown that hypoxia-induced overproduction ROS in defect region has impact on delaying regeneration. However, replenishing excess oxygen short time cause high tension affect activity osteoblast precursor cells. Therefore, reasonably restoring hypoxic condition microenvironment is essential for facilitating repair. Herein, we designed scavenging responsive prolonged oxygen-generating hydrogels (CPP-L/GelMA) as "bone regulative hydrogel" reverse region. CPP-L/GelMA comprises an antioxidant enzyme catalase (CAT) ROS-responsive oxygen-releasing nanoparticles (PFC@PLGA/PPS) co-loaded liposome (CCP-L) GelMA hydrogels. Under condition, can release CAT degrading hydrogen peroxide generate be triggered superfluous continuously more than 2 weeks. The enriched generated hydrogel significantly enhanced angiogenesis osteogenesis while inhibited osteoclastogenesis. Finally, showed excellent regeneration effect mice skull model through Nrf2-BMAL1-autophagy pathway. Hence, CPP-L/GelMA, tissue respiration, effectively scavenge provide supply according demand region, possessing great therapeutic potential.

Язык: Английский

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One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

Advanced Healthcare Materials, Год журнала: 2021, Номер 11(4)

Опубликована: Ноя. 17, 2021

Multifunctional hydrogel as a sealant or wound dressing with high adhesiveness and excellent antibacterial activity is highly desirable in clinical applications. In this contribution, one-step synthetic based on quaternized chitosan (QCS), tannic acid (TA), ferric iron (Fe(III)) developed for skin incision closure Staphylococcus aureus (S. aureus)-infected healing. system, the ionic bonds hydrogen between QCS TA form main backbone of hydrogel, metal coordination Fe(III) (catechol-Fe) endow (near-infrared light) NIR-responsive photothermal property, these multiple dynamic physical crosslinks enable QCS/TA/Fe flexible self-healing ability injectability. Moreover, possesses superior antioxidant, anti-inflammatory, hemostasis, biocompatibility. Also, it safe vital organs. The data from mouse model infected full-thickness presented effectiveness acceleration healing process by multifunctional highlighting its great potential management.

Язык: Английский

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Medicinal Research Reviews, Год журнала: 2023, Номер 43(4), С. 717 - 774

Опубликована: Фев. 9, 2023

Abstract Photodynamic therapy is an alternative treatment mainly for cancer but also bacterial infections. This dates back to 1900 when a German medical school graduate Oscar Raab found photodynamic effect while doing research his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, revealed that the toxicity of acridine on paramecium depends intensity light in laboratory. therefore based administration photosensitizer subsequent irradiation within absorption maxima this substance followed by reactive oxygen species formation and finally cell death. Although not novelty, there endeavor various modifications therapy. For example, selectivity efficiency photosensitizer, as well types sources are still being modified improve final results The main aim review summarize anticancer antibacterial modifications, namely compounds, approaches, techniques, enhance effectiveness

Язык: Английский

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