Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 15, 2022
Exosomes
are
nanoscale
extracellular
vesicles
(EVs),
which
present
in
all
body
fluids
tested.
They
secreted
by
a
variety
of
cells
including
macrophages,
dendritic
cells,
mast
granulocytes,
lymphocytes,
and
tumor
cells.
different
have
biological
components
functional
characteristics
play
an
important
role
many
pathophysiological
activities.
Recent
studies
revealed
that
exosomes
can
regulate
the
occurrence
development
inflammatory
immune
diseases
tumors
transmitting
their
unique
proteins,
lipids,
nucleic
acids
as
signaling
molecules
to
other
serve
novel
class
diagnostic
biomarkers
drug
delivery
systems
with
promising
applications
immunotherapy,
particularly
because
breakthroughs
nanotechnology
led
exploration
engineered
for
immunotargeted
therapies.
Therefore,
here
we
review
progress
being
made
on
application
immunotherapy
its
multiple
regulatory
mechanisms
explore
potential
future.
Cells,
Год журнала:
2021,
Номер
10(8), С. 1959 - 1959
Опубликована: Авг. 1, 2021
Exosomes
are
a
type
of
extracellular
vesicles,
produced
within
multivesicular
bodies,
that
then
released
into
the
space
through
merging
body
with
plasma
membrane.
These
vesicles
secreted
by
almost
all
cell
types
to
aid
in
vast
array
cellular
functions,
including
intercellular
communication,
differentiation
and
proliferation,
angiogenesis,
stress
response,
immune
signaling.
This
ability
contribute
several
distinct
processes
is
due
complexity
exosomes,
as
they
carry
multitude
signaling
moieties,
proteins,
lipids,
surface
receptors,
enzymes,
cytokines,
transcription
factors,
nucleic
acids.
The
favorable
biological
properties
exosomes
biocompatibility,
stability,
low
toxicity,
proficient
exchange
molecular
cargos
make
prime
candidates
for
tissue
engineering
regenerative
medicine.
Exploring
functions
payloads
can
facilitate
regeneration
therapies
provide
mechanistic
insight
paracrine
modulation
activities.
In
this
review,
we
summarize
current
knowledge
exosome
biogenesis,
composition,
isolation
methods.
We
also
discuss
emerging
healing
exosomal
cargos,
such
microRNAs,
brain
injuries,
cardiovascular
disease,
COVID-19
amongst
others.
Overall,
review
highlights
burgeoning
roles
potential
applications
Stem Cell Research & Therapy,
Год журнала:
2019,
Номер
10(1)
Опубликована: Ноя. 21, 2019
Abstract
Degenerative
disorders
of
joints,
especially
osteoarthritis
(OA),
result
in
persistent
pain
and
disability
high
costs
to
society.
Nevertheless,
the
molecular
mechanisms
OA
have
not
yet
been
fully
explained.
is
characterized
by
destruction
cartilage
loss
extracellular
matrix
(ECM).
It
generally
agreed
that
there
an
association
between
pro-inflammatory
cytokines
development
OA.
There
increased
expression
metalloproteinase
(MMP)
“a
disintegrin
with
thrombospondin
motifs”
(ADAMTS).
Mesenchymal
stem
cells
(MSCs)
explored
as
a
new
treatment
for
during
last
decade.
has
suggested
paracrine
secretion
trophic
factors,
which
exosomes
crucial
role,
contributes
mechanism
MSC-based
The
may
play
role
repair
joint
tissue
well
treatments
other
disorders.
Exosomes
isolated
from
various
contribute
regeneration
heart,
limbs,
skin,
tissues.
Recent
studies
indicated
(or
similar
particles)
derived
MSCs
suppress
development.
Herein,
first
time,
we
summarize
recent
findings
on
their
effectiveness
Moreover,
highlight
likely
actions
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Background
Autoimmune
diseases
(AIDs)
are
a
class
of
chronic
disabling
characterized
by
inflammation
and
damage
to
muscles,
joints,
bones,
internal
organs.
Recent
studies
have
shown
that
much
progress
has
been
made
in
the
research
exosomes
AIDs.
However,
there
is
no
bibliometric
analysis
this
field.
This
study
aims
provide
comprehensive
overview
knowledge
structure
hotspots
AIDs
through
bibliometrics.
Method
Publications
related
from
2002
2021
were
searched
on
web
science
core
collection
(WoSCC)
database.
VOSviewers,
CiteSpace
R
package
“bibliometrix”
used
conduct
analysis.
Results
312
articles
48
countries
led
China
United
States
included.
The
number
publications
increasing
year
year.
Central
South
University,
Sun
Yat
Sen
Tianjin
Medical
University
Pennsylvania
main
institutions.
Frontiers
immunology
most
popular
journal
field,
Journal
Immunology
co-cited
journal.
These
come
473
authors
among
which
Ilias
Alevizos,
Qianjin
Lu,
Wei
Wei,
Jim
Xiang
Ming
Zhao
had
published
papers
Clotilde
Théry
was
often.
Studying
mechanism
endogenous
occurrence
development
therapeutic
strategy
exogenous
topics
“Mesenchymal
stem
cells”,
“microRNA”,
“biomarkers”,
“immunomodulation”,
“therapy”
primary
keywords
emerging
hotspots.
Conclusion
first
comprehensively
summarizes
trends
developments
information
identifies
recent
frontiers
hot
directions,
will
reference
for
scholars
studying
exosomes.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 3177 - 3210
Опубликована: Июнь 1, 2023
Abstract:
Exosomes
are
nanovesicles
with
a
wide
range
of
chemical
compositions
used
in
many
different
applications.
Mesenchymal
stem
cell-derived
exosomes
(MSCs-EXOs)
spherical
vesicles
that
have
been
shown
to
mediate
tissue
regeneration
variety
diseases,
including
neurological,
autoimmune
and
inflammatory,
cancer,
ischemic
heart
disease,
lung
injury,
liver
fibrosis.
They
can
modulate
the
immune
response
by
interacting
effector
cells
due
presence
anti-inflammatory
compounds
involved
intercellular
communication
through
various
types
cargo.
MSCs-EXOs
exhibit
cytokine
storm-mitigating
properties
COVID-19.
This
review
discussed
potential
function
diseases
notably
epileptic
encephalopathy
Parkinson's
angiogenesis,
inflammatory
diseases.
We
provided
an
overview
exosome
biogenesis
factors
regulate
biogenesis.
Additionally,
we
highlight
functions
use
treatment
disease
Finally,
covered
strategies
challenges
MSCs-EXOs.
discuss
conclusion
future
perspectives
Keywords:
extracellular
vesicle,
biogenesis,
mesenchymal
cells,
exosomes,
angiogenesis
