Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Nutrients, Год журнала: 2022, Номер 14(19), С. 3934 - 3934

Опубликована: Сен. 22, 2022

Melatonin has become a popular dietary supplement, most known as chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, many other conditions, combined with COVID-19 pandemic, led to greater awareness of melatonin because its ability act potent antioxidant, immune-active agent, mitochondrial regulator. There are distinct similarities between vitamin D in depth breadth their impact on health. Both hormones, affect systems through immune-modulating, anti-inflammatory functions, found skin, responsive sunlight darkness. In fact, there may be widespread concern about deficiency “sunlight deficiency” reduced secretion result “darkness from overexposure artificial blue light. The trend toward use supplements resulted safety, especially higher doses, long-term use, application certain populations (e.g., children). This review aims evaluate recent data melatonin’s mechanisms, clinical uses beyond sleep, safety concerns, thorough summary therapeutic considerations concerning supplementation, including different formats available (animal, synthetic, phytomelatonin), dosing, timing, contraindications, nutrient combinations.

Язык: Английский

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Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies

Antioxidants, Год журнала: 2024, Номер 13(4), С. 439 - 439

Опубликована: Апрель 7, 2024

Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in literature require in-depth analysis. Objectives: This study reviewed on rat models. Methods: We followed guidelines Preferred Reporting Items for Systematic Reviews Meta-analyses PubMed, LILACS, Cochrane databases, Google Scholar, article references, irrespective publication time. Results: Ten articles involving 485 rats were selected, effects markers investigated. increased superoxide dismutase nine studies, glutathione peroxidase seven catalase five studies. In contrast, reduced three studies malonaldehyde eight Conclusion: Our findings suggest effectively reduces oxidative stress.

Язык: Английский

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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5541 - 5571

Опубликована: Янв. 11, 2024

Язык: Английский

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Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective

Journal of Pineal Research, Год журнала: 2022, Номер 72(3)

Опубликована: Фев. 8, 2022

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators by its versatility of functions and mechanisms action, which include the regulation vertebrate pigmentation. Although first discovered through potent skin-lightening effects in amphibians, melatonin's role human skin hair follicle pigmentation impact on melanocyte physiology remain unclear. Synthesizing our limited current understanding this role, we specifically examine melanogenesis, oxidative biology, mitochondrial function, senescence, pigmentation-related clock gene activity, with emphasis skin, yet without ignoring instructive pointers from nonhuman species. Given strict dependence epithelial microenvironment, underscore that responses to melatonin are best interrogated a physiological tissue context. Current evidence suggests some metabolites inhibit both, melanogenesis (via reducing tyrosinase activity) proliferation stimulating membrane receptors (MT1, MT2). We discuss whether putative melanogenesis-inhibitory may occur via activation Nrf2-mediated PI3K/AKT signaling, estrogen receptor-mediated and/or melanocortin-1 receptor- cAMP-dependent melatonin-regulated changes peripheral genes regulate namely Bmal1 Per1. Melatonin also accumulate melanocytes where they exert net cyto- senescence-protective as well antioxidative operating free radical scavengers, synthesis activity ROS scavenging enzymes other antioxidants, promoting DNA repair, enhancing function. argue it is clinically biologically important definitively clarify cell culture-based observations translate into melatonin-induced pigmentary context, is, epidermis follicles ex vivo, confirmed clinical trial results. After defining major open questions field, close suggesting how begin answering them relevant, currently available preclinical situ research models.

Язык: Английский

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Effects of outdoor artificial light at night on human health and behavior: A literature review

Environmental Pollution, Год журнала: 2023, Номер 323, С. 121321 - 121321

Опубликована: Фев. 20, 2023

Язык: Английский

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Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

Antioxidants, Год журнала: 2023, Номер 12(3), С. 695 - 695

Опубликована: Март 11, 2023

Aging has a major detrimental effect on the optimal function of ovary with changes in this organ preceding age-related deterioration other tissues, middle-aged shutdown leading to infertility. Reduced fertility and consequent inability conceive by women present-day societies who choose have children later life leads increased frustration. Melatonin is known anti-aging properties related its antioxidant anti-inflammatory actions. Its higher follicular fluid levels relative blood concentrations likely synthesis oocyte, granulosa, luteal cells suggest that it optimally positioned interfere age-associated ovary. Additionally, end female reproductive span coincides significant reduction endogenous melatonin levels. Thus, aims are review literature indicating production mitochondria oocytes, granulosa cells, identify multiple processes underlying ovary, especially late cessation span, summarize physiological molecular actions maintenance normal ovaries aging ovaries, integrate acquired information into an explanation for considering treatment Use supplemental may help preserve alleviate frustration delaying childbearing age, reduce necessity vitro fertilization–embryo transfer (IVF-ET) procedures, solve progressively increasing problem non-aging-related infertility throughout their span. While additional research needed fully understand effects supplementation potentially enhancing fertility, studies published date be promising option those struggling

Язык: Английский

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Climate change and pregnancy complications: From hormones to the immune response

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Апрель 5, 2023

Pregnant women are highly vulnerable to adverse environments. Accumulating evidence highlights that increasing temperatures associated with the ongoing climate change pose a threat successful reproduction. Heat stress caused by an increased ambient temperature can result in pregnancy outcomes, e.g. , preterm birth, stillbirth and low fetal weight. The pathomechanisms through which heat interferes maintenance still remain vague, but emerging underscores endocrine system is severely affected. It well known pivotally contributes physiological progression of pregnancy. We review – sometimes speculate - how offset hormonal dysregulations subsequently derail other systems interact hormones, such as immune response. This may account for heat-stress related progression, development long-term children’s health.

Язык: Английский

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Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Март 9, 2022

Circadian rhythms are cyclic patterns of physiological, behavioural and molecular events that occur over a 24-h period. They controlled by the suprachiasmatic nucleus (SCN), brain's master pacemaker which governs peripheral clocks melatonin release. While circadian systems endogenous, there external factors synchronise SCN to ambient environment including light/dark cycles, fasting/fed state, temperature physical activity. also provide internal temporal organisation ensures any changes take place centrally coordinated. Melatonin synchronises time regulated gene expression control physiological function. Synchronisation system with is vital for health survival an organism as play pivotal role in regulating GI physiology, disruption may lead gastrointestinal (GI) dysfunction. Disorders gut-brain interactions (DGBIs), known functional disorders (FGIDs), group diseases where patients experience reoccurring symptoms cannot be explained obvious structural abnormalities include dyspepsia (FD) irritable bowel syndrome (IBS). Food timing impacts on production given correlation between food intake symptom onset reported DGBIs, chronodisruption feature these conditions. Recent advances immunology implicate regulation immune responses, DGBI report fatigue disordered sleep, suggesting disruption. Further, treatment has been demonstrated improve burden IBS patients, however, mechanisms underlying this efficacy unclear. Given influence physiology system, modulation potential therapeutic option reducing patients.

Язык: Английский

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Melatonin from Microorganisms, Algae, and Plants as Possible Alternatives to Synthetic Melatonin

Metabolites, Год журнала: 2023, Номер 13(1), С. 72 - 72

Опубликована: Янв. 2, 2023

Melatonin dietary supplements are widely consumed worldwide, with developed countries as the largest consumers, an estimated annual growth rate of approximately 10% until 2027, mainly in developing countries. The wide use melatonin against sleep disorders and particular problems, such jet lag, has been added to other applications, anti-aging, anti-stress, immune system activation, anticancer, others, which have triggered its use, normally without a prescription. chemical industry currently covers 100% needs market. Motivated by sectors more natural consumption habits, few years ago, possibility obtaining from plants, called phytomelatonin, arose. More recently, pharmaceutical genetically modified microorganisms whose ability produce biological bioreactors enhanced. This paper reviews aspects synthesis for human consumption, supplements. pros cons phytomelatonin plants algae analyzed, well advantages melatonin, avoiding unwanted by-products melatonin. Finally, economic quality these new products, some already marketed, analyzed.

Язык: Английский

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Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Янв. 31, 2023

Background Modern societies face infertility as a global challenge. There are certain environmental conditions and disorders that damage testicular tissue may cause male infertility. Melatonin, potential antioxidant, protect tissue. Therefore, we conducted this systematic review meta-analysis to evaluate the effects of melatonin in animal models against physical, heat, ischemic Methods PubMed, Scopus, Web Science were systematically searched identify trials evaluating protective effect therapy on rodent when it is exposed thermal, ischemic, or hypobaric oxygen stress. Random-effect modeling was used estimate standardized mean difference 95% confidence intervals based pooled data. Additionally, Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool assess risk bias. The study protocol prospectively registered PROSPERO (CRD42022354599). Results A total 41 studies eligible out 10039 records. Studies employed direct cryptorchidism, varicocele, torsion-detorsion, vascular occlusion, hypoxia, ischemia-reperfusion, stress by excessive restraint activity, spinal cord injury, trauma induce subjects. histopathological characteristics generally improved rodents therapy. Based data, sperm count, morphology, forward motility, viability, Johnsen’s biopsy score, glutathione peroxidase, superoxide dismutase levels higher treatment arms. In contrast, malondialdehyde level lower included suffered from high bias most SYRCLE domains. Conclusion This concludes associated with characteristics, reproductive hormonal panel, markers oxidative thermal injuries. regard, deserves scientific investigations drug registration https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42022354599.

Язык: Английский

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