Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure DOI Creative Commons

Arijana Demaili,

Anna Portugalov,

Michal Dudai

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Фев. 22, 2023

Environmental factors, including stress, that are experienced during early life (ELS) or adolescence potential risk factors for the development of behavioral and mental disorders later in life. The endocannabinoid system plays a major role regulation stress responses emotional behavior, thereby acting as mediator vulnerability resilience. Among critical which determine magnitude direction long-term consequences exposure is age, i.e., maturity brain circuits exposure. Thus, present study addressed hypotheses ELS adolescent differentially affect expression regulatory elements system, cannabinoid receptor 1 (CB1R) fatty acid amide hydrolase (FAAH) medial prefrontal cortex (mPFC) adult female rats. We also tested hypothesis proposed gene changes epigenetically modulated via altered DNA-methylation. specific aims were to investigate if (i) single stressors induce CB1R FAAH (ii) influences effect on expression, (iii) paralleled by DNA methylation. following experimental groups investigated: (1) non-stressed controls (CON), (2) (ELS), (3) (forced swimming; FS), (4) + FS found an up-regulation both single-stressor reduction back control levels group. An was only data indicate ELS, very immature stage development, exerts buffering programming induced stress. detected accompanied methylation patterns promoter region these genes, specifically, negative correlation mean with found. Our results induces “(re)programming” effect, characterized CpG-site within regions two genes influence response at adolescence.

Язык: Английский

The Microbiota–Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Aleksandra Góralczyk-Bińkowska, Dagmara Szmajda‐Krygier, Elżbieta Kozłowska

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11245 - 11245

Опубликована: Сен. 24, 2022

Modulating the gut microbiome and its influence on human health is subject of intense research. The microbiota could be associated not only with gastroenterological diseases but also psychiatric disorders. importance factors such as stress, mode delivery, role probiotics, circadian clock system, diet, occupational environmental exposure in relationship between brain function through bidirectional communication, described "the microbiome-gut-brain axis", especially underlined. In this review, we discuss link intestinal host response involving different pathways nervous system (e.g., neurotransmitters, endocrine immunological mechanisms, or bacterial metabolites). We review alterations their results development disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar (BD), autism spectrum (ASD), attention-deficit hyperactivity (ADHD).

Язык: Английский

Процитировано

233
Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications DOI
Alexandria Tartt,

Madeline Mariani,

René Hen

и другие.

Molecular Psychiatry, Год журнала: 2022, Номер 27(6), С. 2689 - 2699

Опубликована: Март 30, 2022

Язык: Английский

Процитировано

229
Annual Research Review: The power of predictability – patterns of signals in early life shape neurodevelopment and mental health trajectories DOI Creative Commons
Elysia Poggi Davis, Laura M. Glynn

Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер 65(4), С. 508 - 534

Опубликована: Фев. 20, 2024

The global burden of early life adversity (ELA) is profound. World Health Organization has estimated that ELA accounts for almost 30% all psychiatric cases. Yet, our ability to identify which individuals exposed will develop mental illness remains poor and there a critical need underlying pathways mechanisms. This review proposes unpredictability as an understudied aspect tractable presents conceptual model includes biologically plausible mechanistic by impacts the developing brain. supported synthesis published new data illustrating significant patterns signals on child development. We begin with overview existing literature, focused primarily longer (e.g. years, months, days). then describe work testing impact parental moment‐to‐moment timescale, providing evidence these during sensitive windows development influence neurocircuit formation across species thus may be evolutionarily conserved process shapes Next, attention drawn emerging themes provide framework future directions research including evaluation functions, such effortful control, particularly vulnerable unpredictability, periods, sex differences, cross‐cultural investigations, addressing causality, pathway other forms Finally, we suggestions prevention intervention, introduction screening instrument identification children unpredictable experiences.

Язык: Английский

Процитировано

21
Adoption and trauma: Risks, recovery, and the lived experience of adoption DOI
David M. Brodzinsky, Megan R. Gunnar, Jesús Palacios

и другие.

Child Abuse & Neglect, Год журнала: 2021, Номер 130, С. 105309 - 105309

Опубликована: Сен. 17, 2021

Язык: Английский

Процитировано

60
Cell-type-specific epigenetic effects of early life stress on the brain DOI Creative Commons
Mouly F. Rahman, Patrick O. McGowan

Translational Psychiatry, Год журнала: 2022, Номер 12(1)

Опубликована: Авг. 10, 2022

Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased vulnerability a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA, are proposed link between environmental stressors, alterations in gene expression, phenotypes. play primary role shaping functional differences cell types can be modified by perturbations, especially early development. Together with contributions from genetic variation, epigenetic mechanisms orchestrate patterns expression within specific variation individuals. To date, many studies have provided insights into changes resulting ELS. However, most these examined heterogenous brain tissue, despite evidence cell-type-specific phenotypes associated In this review, we focus on rodent human induced ELS select isolated the or genes cell-type-restricted neurons, microglia, astrocytes, oligodendrocytes. Although significant challenges remain, future using approaches enable important mechanistic insight effects function.

Язык: Английский

Процитировано

50
Encore: Behavioural animal models of stress, depression and mood disorders DOI Creative Commons
Aleksa Petković, Dipesh Chaudhury

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Авг. 8, 2022

Animal studies over the past two decades have led to extensive advances in our understanding of pathogenesis depressive and mood disorders. Among these, rodent behavioural models proved be highest informative value. Here, we present a comprehensive overview most popular with respect physiological, circuit, molecular biological correlates. Behavioural stress paradigms tests are assessed terms outcomes, strengths, weaknesses, translational value, especially domain pharmacological studies.

Язык: Английский

Процитировано

44
Life stress, insomnia, and anxiety/depressive symptoms in adolescents: A three-wave longitudinal study DOI
Yanyun Yang, Xianchen Liu, Zhenzhen Liu

и другие.

Journal of Affective Disorders, Год журнала: 2022, Номер 322, С. 91 - 98

Опубликована: Ноя. 11, 2022

Язык: Английский

Процитировано

39
Biological Embedding of Early-Life Adversity and a Scoping Review of the Evidence for Intergenerational Epigenetic Transmission of Stress and Trauma in Humans DOI Open Access
Aoshuang Zhou, Joanne Ryan

Genes, Год журнала: 2023, Номер 14(8), С. 1639 - 1639

Опубликована: Авг. 17, 2023

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence suggests that early-life adversity become biologically embedded has the potential to influence health outcomes decades later. Epigenetics is one mechanism been implicated in these long-lasting effects. Observational studies humans indicate effects of could even persist across generations, although whether not epigenetic mechanisms are involved remains under debate. Here, we provide an overview animals demonstrate DNA methylation, most widely studied mechanisms, summarize findings from animal models demonstrating involvement epigenetics transmission generations. We then describe results scoping review determine extent which terms intergenerational transgenerational used human investigating via mechanisms. end with discussion key areas for future research advance understanding role legacy trauma.

Язык: Английский

Процитировано

26
Consequences of war-related traumatic stress among Palestinian young people in the Gaza Strip: A scoping review DOI Creative Commons
Abdallah Abudayya,

Geir Tarje Fugleberg Bruaset,

Hedda Bøe Nyhus

и другие.

Mental Health & Prevention, Год журнала: 2023, Номер 32, С. 200305 - 200305

Опубликована: Ноя. 25, 2023

The long-standing Israeli–Palestinian conflict has escalated since the beginning of 20th century, resulting in a humanitarian crisis Palestine. It caused significant psychological and social suffering, particularly children young people. Firstly, to identify synthesize existing knowledge available peer review articles about consequences war-related trauma reactions among people, secondly investigate mechanisms resilience context Gaza Strip. follows Arksey O'Malley's methodological framework, including systematic search eight databases. Relevant studies were assessed according inclusion exclusion criteria. identified used various measurement tools instruments assess mental health outcomes, post-traumatic stress disorder (PTSD), anxiety, depression, resilience. War-related traumatic experiences common children. determinants that increased problems also identified, exposure violence destruction, loss family members friends. Resilience coping have crucial role mitigating negative impact trauma. people Strip is pressing public concern, PTSD, anxiety. Nonetheless, more qualitative research required address gaps improve service. This study could provide valuable insights for creating interventions support services are culturally tailored.

Язык: Английский

Процитировано

24
Childhood maltreatment and resting-state network connectivity: The risk-buffering role of positive parenting DOI
Xinyu Cao,

Zhengxinyue Wang,

Yuanyuan Chen

и другие.

Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Апрель 2, 2024

Abstract Unraveling the neurobiological foundations of childhood maltreatment is important due to persistent associations with adverse mental health outcomes. However, mechanisms through which abuse and neglect disturb resting-state network connectivity remain elusive. Moreover, it remains unclear if positive parenting can mitigate negative impact on connectivity. We analyzed a cohort 194 adolescents young adults (aged 14–25, 47.42% female) from Neuroscience in Psychiatry Network (NSPN) investigate Specifically, we examined SAN, DMN, FPN, DAN, VAN over time. also explored moderating role parenting. The results showed that was linked stronger within SAN VAN, as well between DMN-DAN, DMN-VAN, DMN-SAN, SAN-DAN, FPN-DAN, SAN-VAN, VAN-DAN networks about 18 months later. Positive during buffered To our knowledge, this first study demonstrate protective effect following abuse. These findings not only highlight importance but lead better understanding neurobiology resilience maltreatment.

Язык: Английский

Процитировано

10