Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors

Metabolism, Год журнала: 2023, Номер 149, С. 155711 - 155711

Опубликована: Окт. 21, 2023

Язык: Английский

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Meta‐analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(4), С. 1240 - 1253

Опубликована: Май 7, 2024

Sarcopenia has been associated with adverse health outcomes, including cognitive dysfunction. However, its specific interrelationship neurocognitive disorders such as mild impairment (MCI), Alzheimer's disease (AD) or other types of dementia not thoroughly explored. This meta-analysis aims to summarize the existing evidence on this interrelationship. systematic review was pre-registered PROSPERO (CRD42022366309) and reported according Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines. Databases, PubMed, Embase, CINAHL, Scopus, Web Science, PEDro, SPORTDiscus Cochrane Central Register Controlled Trials, data registry ClinicalTrials.gov were searched from inception 8 June 2023. Observational studies (cross-sectional cohort) interventional reporting association prevalence sarcopenia in MCI, AD adults ≥50 years included. For meta-analysis, pooled odds ratios (OR) 95% confidence intervals (CI) calculated using random-effects/fixed-effects models. Subgroup analyses performed identify potential sources heterogeneity. A total 77 consisting 92 058 subjects finally included qualitative analysis (71 cross-sectional, 4 cohort 2 studies). Studies heterogeneous, different diagnostic criteria define both status. The majority (n = 38) Asian community-dwelling older adults. Most investigated (33/77) MCI (32/77). focusing forms dementia, two Lewy body one study Parkinson's whereas remaining did specify aetiology 21). Three explored between incident only sarcopenia. Two whether an exercise programme could prevent progression AD. information extracted 26 studies. significantly (pooled OR 1.58, CI 1.42-1.76) 14), 2.97, 2.15-4.08) 3) non-AD 1.68, 1.09-2.58) 9). significance magnitude associations differed subgroup by design, population, definition used tool measure showed that is dementia. These findings suggest importance early screening prevention people dysfunction, although further longitudinal research needed clarify causal relationship.

Язык: Английский

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Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Март 8, 2024

Background Early-onset sarcopenia refers to the progressive loss of muscle mass and function that occurs at an early age. This condition perpetuates vicious cycle is associated with adverse outcomes. It important identify contributing factors for intervention prevention. While diet known impact mass, association B vitamins early-onset remains unexplored. Objectives To investigate intake risk in a cross-sectional study. Methods We conducted data analysis on total 8,711 participants aged between 20 59 years who took part National Health Nutrition Examination Survey (NHANES) from 2011 2018. was defined as SMI measured by DXA one standard deviation below sex-specific mean reference population. (B1, B2, B3, B6, B9, B12) assessed 24-h dietary recall. used weighted multiple logistic regression RCS models estimate OR 95% CI intake, adjusting demographic, physical, lifestyle, comorbidities, nutritional covariates. Results Higher vitamin B1 22% lower (OR = 0.78, 0.63–0.97, p 0.022), higher B2 16% 0.84, 0.74–0.97, 0.012) both genders. Gender-specific analyses showed 28% reduction among males each additional mg 0.72, 0.52–0.97, 0.038), 26% decrease females 0.74, 0.57–0.96, 0.021). No significant differences were found males, or females. The model suggested nonlinear relationship ( P Overall 0.001, Nonlinear 0.033), plateau effect above 3 mg/d. Conclusion may sarcopenia, gender differences. suggests potential increasing these through supplements. Further research warranted elucidate mechanisms design targeted interventions.

Язык: Английский

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Preoperative mild cognitive impairment as a risk factor of postoperative cognitive dysfunction in elderly patients undergoing spine surgery

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Янв. 12, 2024

Any persistent degree of cognitive impairment in older adults is a concern as it can progress to dementia. This study aimed determine the incidence and risk factors for early postoperative dysfunction (POCD) elderly patients undergoing spine surgery.

Язык: Английский

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A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 5, 2025

Abstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the maximum muscle circumference (CMMC) measured by ultrasound and not reported. We aims to construct a predictive model for based on CMMC in hospitalized older patients. Methods This was retrospective controlled study of patients > 60 years age geriatric department Hunan Provincial People’s Hospital. were thoroughly evaluated questionnaires, laboratory, examinations, including measuring thickness using ultrasound. Patients categorized into non-sarcopenia groups according consensus diagnosis recommended Asian Working Group Sarcopenia 2019 (AWGS2). Independent predictors identified univariate multivariate logistic regression analyses, developed simplified. prediction performance models assessed sensitivity, specificity, area under curve (AUC) compared with independent predictors. Results found that patient age, albumin level (ALB), brachioradialis (BRMT), gastrocnemius lateral head (Glh MT), established simplified Logistic P = -4.5 + 1.4 × 1.3 ALB 1.6 BR MT 3.7 1.8 Glh MT, best cut-off value 0.485. AUC 0.884 (0.807–0.962), 0.837 (0.762–0.911), 0.927 (0.890–0.963), respectively. kappa coefficient this diagnostic criteria AWGS2 0.709. Conclusion constructed five variables: level, CMMC. could quickly predict

Язык: Английский

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The association between dietary vitamins and the risk of sarcopenia in adults aged 20–59: a study based on the NHANES database

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

Background Sarcopenia has emerged as a global health concern, but the association between dietary vitamin levels and sarcopenia is not elucidated. This study aims to shed light on link of 11 vitamins risk in adults at age 20–59. Methods cross-sectional encompassed 2011–2018 data from National Health Nutrition Examination Survey (NHANES) for aged was defined through appendicular lean mass body index ratio calculated via Dual-Energy X-ray Absorptiometry (DXA), with determined <0.789 male <0.512 female. Multivariate weighted logistic regression assisted assessing connection sarcopenia, results presented odds ratios (ORs) 95% confidence intervals (CIs). The dose-response various visualized restricted cubic splines (RCS). Subgroup analyses were carried out examine consistency aforementioned associations. Sensitivity analysis performed utilizing propensity score matching (PSM) adjust confounding factors enhance robustness results. Results Among 7,864 participants, 677 (8.6%) had 7,187 (91.4%) did not. RCS indicated that higher intakes VA, VB1, VB2, VB3, VB6, VB9, VB12, VC, VE, VK notably linked lowered ( P < 0.05). these, VE exhibited non-linear negative 0.05), while linear > yielded largely consistent After adjusted PSM, suggest intake VC remains significantly associated Conclusion Higher are related lower livelihood sarcopenia. These findings provide new evidence insights early interventions aimed preventing

Язык: Английский

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The longitudinal bidirectional association between sarcopenia and cognitive function in community-dwelling older adults: Findings from the China Health and Retirement Longitudinal Study

Journal of Global Health, Год журнала: 2023, Номер 13

Опубликована: Дек. 27, 2023

Although an association between sarcopenia and cognitive function has been demonstrated, the directional remains unclear. The present study aimed to evaluate longitudinal reciprocal relationship identify possible temporal sequence in older Chinese adults.Data were collected from China Health Retirement Longitudinal Study (CHARLS) baseline survey 2011 follow-up 2015. Cognitive was measured by episodic memory executive function. Sarcopenia status (non-sarcopenia, sarcopenia) defined based on Asian Working Group for 2019 criteria. Linear regression analysis ordinal logistic employed investigate cognition, as well of cognition with status, respectively. A cross-lagged panel performed simultaneously bidirectional strength relationship.Of 2689 participants, median age 65.0 years 1249 (46.5%) female. After adjusting potential confounders measurements, dose-dependently associated subsequent scores (β = -0.45; P trend 0.001), (in tertiles) also (odds ratio (OR) 0.86; 0.017). indicated that standardised effect size -0.09; < 0.001) is larger relative -0.05; 0.019).There a longitudinal, adults. likely driving force these dynamic associations. These findings imply interventions either or decline may have ability generate benefits over time. More research warranted confirm further elucidate underlying causal pathways.

Язык: Английский

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Sex Differences in the Impact of Dynapenic Abdominal Obesity on Mild Cognitive Impairment among Korean Elderly in the Community

Healthcare, Год журнала: 2024, Номер 12(6), С. 662 - 662

Опубликована: Март 15, 2024

Abdominal obesity (AO) and dynapenia (DP) are associated with cognitive decline, the relationship between dynapenic abdominal (DAO), a combination of DP AO, mild impairment (MCI) has been confirmed. This study aims to determine whether this exhibits potential sex differences. The MCI DAO was confirmed in 1309 community elderly individuals aged 65 years or older who were not diagnosed dementia. defined as Korean mini-mental state examination (K-MMSE) score 18–23 points. Multiple logistic regression analyses conducted, categorizing participants into groups: control group without AO DP, an group, group. results showed that women, both significantly only unadjusted Model 1 but also 2, which adjusted for general characteristics health behaviors, 3, additionally chronic diseases disease-related characteristics. In men, 1. findings highlight differences impact on MCI. These should be considered when studying factors related old age.

Язык: Английский

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Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults

Nutrients, Год журнала: 2024, Номер 16(7), С. 1001 - 1001

Опубликована: Март 29, 2024

Many studies suggest a significant association between individual essential trace elements (ETEs) and cognitive impairment in older adults, but evidence of the synchronized effect multiple ETEs on function is lacking. We investigated ETEs, with no dementia (CIND), executive Korean using Bayesian kernel machine regression (BKMR) model. Three hundred thirty-six adults were included as study population classified CIND control groups. Blood manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo) measured relevant ETEs. The frontal/executive tests digit symbol coding (DSC), color word Stroop test (K-CWST), controlled oral (COWAT), trial-making (TMT). Overall, BKMR showed negative odds CIND. Mn was designated most dominant element associated (PIP = 0.6184), U-shaped relationship. Cu Se levels positively K-CWST percentiles (β 31.78; 95% CI: 13.51, 50.06) DSC 25.10; 7.66, 42.53), respectively. Our results that exposure to may be linked protective mechanism against adults.

Язык: Английский

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Association between life’s essential 8 and cognitive impairment in older patients: results from NHANES 2011–2014

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 14, 2024

Abstract Background This study aimed to examine the association between American Heart Association’s (AHA) newly revised Life’s Essential 8 (LE8) algorithm, designed for assessing cardiovascular health (CVH), and cognitive impairment among older adults in United States. Methods employed a cross-sectional design, utilizing data from 2011–2014 National Health Nutrition Examination Survey explore relationship CVH adults. scores are assessed based on AHA definition of LE8, categorized into three tiers: low (0–49), medium (50–79), high (80–100). Cognitive is evaluated using distinct scoring systems: Consortium Establish Registry Alzheimer’s Disease (CERAD), Animal Fluency Test (AFT), Digit Symbol Substitution (DSST). The lowest quartile as cut-off point; below or equal lower was considered population, above normal population. To analyze association, multivariable logistic regression restricted cubic spline (RCS) models were employed. Results A significant negative correlation exists LE8 impairment. After adjusting multiple variables, odds ratios (OR) impairment, measured by CERAD, AFT, DSST, compared patients with CVH. results indicated OR values 0.60 (95% CI: 0.36–0.98), 0.72 0.52–0.97), 0.29 0.16–0.53) respectively. Additionally, RCS curve demonstrated linear lifestyle factors encapsulated Conclusions findings indicate higher adherence associated Furthermore, maintaining optimal crucial preventing

Язык: Английский

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