European Journal of Dentistry,
Год журнала:
2023,
Номер
18(01), С. 397 - 400
Опубликована: Авг. 2, 2023
Abstract
Objectives
Thus,
the
aim
of
this
study
was
to
compare
effect
using
two
preoperative
mouthwashes
(0.12%
chlorhexidine
and
0.2%
tea
tree
oil)
on
number
colonies
oral
microorganisms.
Materials
Methods
Forty
participants
who
needed
be
rehabilitated
with
dental
implants
were
included
in
study.
They
randomly
divided
into
groups
(chlorhexidine
group
group;
n
=
20,
each).
For
each
group,
saliva
samples
collected
at
four
different
times:
T0
(initially)—before
mouthwash,
T1—after
1
minute
T10—after
10
minutes
T60—after
60
mouthwash.
At
T1,
before
implant
placement
surgery,
T10
T60,
during
surgery.
In
one
sample
evaluated
time
point
for
patient,
totaling
4
collections
per
patient.
MSB
agar
(Mitis-Salivarius-Bacitracin)
BHI
(Brain
Heart
Infusion)
culture
media
used
group.
Microbial
colony
counts
performed
a
magnifying
glass
recorded
CFU
(colony
forming
units)/mL.
Statistical
analyses
Friedman,
Mann–Whitney
U
Wilcoxon
tests
(p
<
0.05).
Results
Based
medium,
T0,
Streptococcus
mutans
significantly
higher
compared
<0.05;
agar).
The
showed
lower
CFU/mL
values
T10,
T60
value
0.05;
Conclusion
Chlorhexidine
is
more
indicated
as
mouthwash
than
oil,
due
its
effective
antimicrobial
action.
PubMed,
Год журнала:
2024,
Номер
14(4), С. 430 - 454
Опубликована: Июль 2, 2024
Periodontitis
is
a
type
of
prevalent
chronic
inflammatory
disorder
resulting
in
failure
the
function
tissues
supporting
tooth,
like
gingiva,
alveolar
bone,
and
periodontal
ligament.
Although
antibiotic
therapy
common
for
periodontitis
cases,
this
approach
can
cause
some
adverse
effects
these
patients.
Thus,
finding
an
effective
curative
option
with
low
side
still
puzzle.
Journal of Advanced Periodontology & Implant Dentistry,
Год журнала:
2024,
Номер
16(2), С. 94 - 102
Опубликована: Сен. 11, 2024
Background.
The
vehicle
in
a
local
drug
delivery
(LDD)
system
plays
vital
role
delivering
the
active
component
at
diseased
site.
Liquid/injectable
platelet-rich
fibrin
(i-PRF),
an
autologous
matrix,
might
be
used
as
to
enmesh
drugs
and
deliver
locally
periodontally
sites.
This
study
evaluated
efficacy
of
(ciprofloxacin
[Cip])-loaded
i-PRF
LDD
adjunct
subgingival
debridement
subjects
with
periodontal
pockets.
Methods.
In
parallel
design
study,
79
pocket
sites
were
randomized
3
groups:
group
1
(n=25),
scaling
root
planing
(SRP)+i-PRF+Cip;
2
SRP+i-PRF;
SRP
without
any
adjunctive
intervention.
Clinical
parameters
(probing
depth
[PD],
clinical
attachment
level
[CAL],
gingival
index
[GI],
plaque
[PI])
microbial
quantification
(relative
levels
Aggregatibacter
actinomycetemcomitans)
assessed
from
baseline
6th
12th
weeks
follow-up.
Results.
All
treatment
groups
showed
significant
improvements
assessed.
Group
significantly
higher
PD
GI
reduction
CAL
gain
decreased
relative
A.
actinomycetemcomitans
week,
followed
by
compared
3.
Conclusion.
Thus,
within
limits
this
it
can
concluded
that
could
considered
potential
for
ciprofloxacin
therapy.
Pharmaceutics,
Год журнала:
2025,
Номер
17(6), С. 697 - 697
Опубликована: Май 26, 2025
The
purpose
of
this
narrative
review
is
to
identify
and
present
clinical
trials
published
in
the
last
five
years
on
local
delivery
agents
used
as
adjuncts
subgingival
instrumentation
non-surgical
management
periodontitis.
Epidemiological
studies
have
shown
that
periodontitis
highly
prevalent
general
population.
Treatment
usually
based
mechanical
removal
contaminants
from
root
surface
followed
by
long-term
supportive
care,
resulting
decreased
occurrence
tooth
loss.
Clinical
health
not
always
achieved
at
all
sites,
leading
research
efforts
researchers
find
adjunctive
help
improve
periodontal
condition.
This
aims
most
recent
developments
for
treatment
Therapies
included
antimicrobial
photodynamic
therapy
well
biomodulating
compounds.
A
search
PubMed
was
conducted
randomized
controlled
relating
locally
delivered
beyond
traditional
therapies
such
chlorhexidine,
minocycline
doxycycline.
Thirty-one
articles
were
included.
current
evidence
human
supports
that,
despite
high
variability
experimental
protocols,
there
may
be
a
benefit
gels
carrying
sodium
hypochlorite,
melatonin,
tea
tree
oil
Aloe
vera.
Most
recently,
advances
nanotechnology,
including
liposomes,
an
avenue
forward
potentially
increase
effectiveness
future
Heliyon,
Год журнала:
2023,
Номер
9(7), С. e17789 - e17789
Опубликована: Июль 1, 2023
ObjectiveThis
systematic
review
and
meta-analysis
evaluated
the
effect
of
use
available
drugs
loaded
gels
used
as
adjunct
to
non-surgical
periodontal
therapy.MethodsSystematic
research
on
PubMed/MEDLINE,
Cochrane
Central
register
Controlled
Trials,
Embase
databases
up
December
2021
was
performed.
Randomized
clinical
trials
(RCT)
which
compared
outcomes
scaling
root
planing
(SRP)
+
local
adjuvant
administration
(gel)
versus
SRP
placebo
or
alone
in
Humans
were
included.
The
primary
outcome
measures
PPD
CAL
changes
at
3
months.ResultsAfter
articles
screening,
77
included
assessed
for
quality.
Then,
a
conducted
studies
with
least
months
follow-up.
Clinical
improvements
found
be
significant
tetracyclines
(−0.51
[-0.71;-0.31]
p
<
0.001),
macrolides
(−0.71
[-1.04;-0.38]
statins
(−0.84
[-0.98;-0.70]
metformin
(−1.47
[-1.66;-1.29]
0.001)
hyaluronan
(−1.61
[-2.28;-0.94]
gels,
but
non-significant
chlorhexidine
(−0.48
[-1.10;
0.14]
=
0.13),
metronidazole
(−0.50
[-1.20;
0.20]
0.16)
bisphosphonates
(−0.42
[-1.39;
0.54]
0.539)
gels.ConclusionAdjunctive
periodondal
treatment
could
improve
reduction
months.
However,
huge
disparities
remain
when
comparing
differents
used.
Future
comparative
should
considered
determine
precisely
short
long
term
benefits
such
treatments.
Biomolecules,
Год журнала:
2023,
Номер
13(11), С. 1576 - 1576
Опубликована: Окт. 26, 2023
Naturally
sourced
products
like
propolis
are
commonly
employed
for
the
non-surgical
treatment
of
periodontal
pockets.
The
use
nanoparticle
formulations
these
natural
remedies
has
potential
to
improve
outcomes.
aim
present
study
was
evaluate
efficacy
sub-gingivally
delivered
nanoparticles
in
management
Forty
patients
diagnosed
with
periodontitis
presenting
at
least
one
pocket
a
probing
depth
between
4
and
6
mm
were
selected.
Patients
randomly
assigned
into
control
group
(
Endocrine Metabolic & Immune Disorders - Drug Targets,
Год журнала:
2022,
Номер
23(4), С. 470 - 484
Опубликована: Июнь 30, 2022
Under
steady-state
circumstances,
the
oral
microbiota
is
in
equilibrium
with
host
tissues,
thus
contributing
to
local
and
systemic
health.
Any
interruption
of
such
leads
a
condition
dysbiosis
proliferation
pathogens
able
cause
gingivitis
periodontal
disease.
The
mechanisms
periodontitis
will
be
described,
mostly
emphasizing
noxious
effects
exerted
by
on
periodontium
either
directly
or
indirectly
via
release
an
array
mediators,
even
including
pro-inflammatory
cytokines,
chemokines,
enzymes.
persistence
inflammation
ultimately
inflammation;
therefore,
link
between
obesity,
diabetes
cardiovascular
disease
elucidated.
Some
natural
compounds,
as
polyphenols,
prebiotics,
probiotics,
discussed
for
their
ability
exert
anti-inflammatory
anti-oxidant
activities
context
inflamed
buccal
cavity
systemically,
well
modulation
altered
gum-gut
microbiota.
Phytotherapy Research,
Год журнала:
2023,
Номер
38(2), С. 727 - 754
Опубликована: Ноя. 28, 2023
Abstract
Antimicrobial
resistance
(AMR)
emerges
as
a
severe
crisis
to
public
health
and
requires
global
action.
The
occurrence
of
bacterial
pathogens
with
multi‐drug
appeals
exploring
alternative
therapeutic
strategies.
Antivirulence
treatment
has
been
positive
substitute
in
seeking
circumvent
AMR,
which
aims
target
virulence
factors
directly
combat
infections.
Accumulated
evidence
suggests
that
plant‐derived
natural
products,
have
utilized
treat
infectious
diseases
for
centuries,
can
be
abundant
sources
screening
potential
virulence‐arresting
drugs
(VADs)
develop
advanced
therapeutics
diseases.
This
review
sums
up
some
their
actions
various
species
bacteria,
well
recent
advances
pertaining
products
VAD
candidates.
Furthermore,
we
also
discuss
VAD‐related
clinical
trials
patents,
the
perspective
VAD‐based
critical
challenges
hampering
use
VADs,
genomics‐guided
identification
therapeutic.
These
newly
discovered
VADs
will
encouraging
optimistic
candidates
may
sustainably
AMR.
