Efficacy of Locally Delivered Tea Tree Oil Gel as an Adjunct to Non-surgical Periodontal Management; A Randomized Controlled Clinical Trial DOI Open Access
Rawan Ayman Ebrahim,

Hala Abuel Ela,

Hadeel Gamal Almalahy

et al.

Egyptian Dental Journal /Egyptian Dental Journal, Journal Year: 2024, Volume and Issue: 70(1), P. 139 - 146

Published: Jan. 1, 2024

Objective: The aim of this controlled randomized clinical trial is to assess the impact intra pocket application Tea Tree Oil (TTO) gel. Methods and materials: Twenty-two patients, both genders, aged 20 50, were diagnosed with moderate severe periodontitis. Two groups selected: test group, which included eleven patients who received nonsurgical periodontal therapy (NSPT) locally delivered TTO gel, control only NSPT. following parameters considered clinically at baseline three months after NSPT: plaque index (PI), modified sulcular bleeding (MSBI), probing depth (PD), attachment level (CAL). Patient Satisfaction Questionnaire Short Form (PSQ-18) was assessed postoperatively in groups. Results: Three postoperatively, data shows better improvement group than group. PSQ-18 showed patient satisfaction Conclusion: Adjunctive local delivery gel together NSPT periodontitis has effect that alone. Keywords: Local drug delivery, tree oil Gel, Non-surgical Periodontal Therapy, Clinical Attachment Level.

Language: Английский

Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review DOI Open Access
Sarhang Gul, Faraedon Zardawi, Ali A. Abdulkareem

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(5), P. 3131 - 3131

Published: March 7, 2022

Purpose: To explore whether baseline matrix metalloproteinase (MMP)-8 level in gingival crevicular fluid (GCF) (exposure) can predict the outcome (reduction probing pocket depth (PPD) (outcome)) of nonsurgical periodontal therapy (NSPT) (manual or ultrasonic both) patients with periodontitis (population/problem) after 3 months. Methods: Six databases (PubMed, Cochrane library, ProQuest, Ovid, Scopus, EBSCO) were searched for relevant articles published until 30 July 2021. Retrieved passed through a three-phase filtration process on basis eligibility criteria. The primary was change PPD Quality selected assessed using Risk Bias tool (RoB2) and In Non-Randomized Studies Interventions (ROBINS-I) tools. Results: From 1306 articles, five analysis. results showed high variations GCF MMP-8 at baseline. average amount reduction 1.20 2.30 mm pockets initial 4–6 >6 mm, respectively. Conclusion: On available evidence, it not possible to reach consensus ability forecast NSPT. This could have been due variation clinical laboratory techniques used. However, consistency mean months shown.

Language: Английский

Citations

17
Essential Oils for Biofilm Control: Mechanisms, Synergies, and Translational Challenges in the Era of Antimicrobial Resistance DOI Creative Commons
Abdelaziz Touati, Assia Mairi, Nasir A. Ibrahim

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 503 - 503

Published: May 13, 2025

Biofilms, structured microbial consortia embedded in self-produced extracellular matrices, pose significant challenges across the medical, industrial, and environmental sectors due to their resistance antimicrobial therapies ability evade immune system. Their resilience is driven by multifaceted mechanisms, including matrix-mediated drug sequestration, metabolic dormancy, quorum sensing (QS)-regulated virulence, which collectively sustain persistent infections contribute amplification of (AMR). This review critically examines potential plant-derived essential oils (EOs) as innovative agents for biofilm control. EOs exhibit broad-spectrum antibiofilm activity through multi-target disrupting initial adhesion, degrading polymeric substances (EPSs), suppressing QS pathways, compromising membrane integrity. act synergistically with conventional antimicrobials at sub-inhibitory concentrations enhances therapeutic efficacy while reducing selection pressure resistance. Despite potential, EO applications face technical challenges, such compositional variability botanical sources, formulation stability issues, difficulties standardization large-scale production. Clinical translation further complicated stage- strain-dependent efficacy, insufficient vivo validation outcomes, cytotoxicity higher doses. These limitations underscore need optimized delivery systems, nanoencapsulation, enhance bioavailability mitigate adverse effects. Future strategies should include combinatorial approaches antibiotics or EPS-degrading enzymes, advanced technologies, standardized protocols bridge laboratory findings clinical practice. By addressing these hold transformative biofilm-associated AMR, offering sustainable, alternatives infection management prevention diverse contexts.

Language: Английский

Citations

0
Gels as adjuvant to non-surgical periodontal therapy: A systematic review and meta-analysis DOI Creative Commons
Pierre‐Yves Gegout, Céline Stutz, Olivier Huck

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(7), P. e17789 - e17789

Published: July 1, 2023

ObjectiveThis systematic review and meta-analysis evaluated the effect of use available drugs loaded gels used as adjunct to non-surgical periodontal therapy.MethodsSystematic research on PubMed/MEDLINE, Cochrane Central register Controlled Trials, Embase databases up December 2021 was performed. Randomized clinical trials (RCT) which compared outcomes scaling root planing (SRP) + local adjuvant administration (gel) versus SRP placebo or alone in Humans were included. The primary outcome measures PPD CAL changes at 3 months.ResultsAfter articles screening, 77 included assessed for quality. Then, a conducted studies with least months follow-up. Clinical improvements found be significant tetracyclines (−0.51 [-0.71;-0.31] p < 0.001), macrolides (−0.71 [-1.04;-0.38] statins (−0.84 [-0.98;-0.70] metformin (−1.47 [-1.66;-1.29] 0.001) hyaluronan (−1.61 [-2.28;-0.94] gels, but non-significant chlorhexidine (−0.48 [-1.10; 0.14] = 0.13), metronidazole (−0.50 [-1.20; 0.20] 0.16) bisphosphonates (−0.42 [-1.39; 0.54] 0.539) gels.ConclusionAdjunctive periodondal treatment could improve reduction months. However, huge disparities remain when comparing differents used. Future comparative should considered determine precisely short long term benefits such treatments.

Language: Английский

Citations

7
Efficacy of Sub-Gingivally Delivered Propolis Nanoparticle in Non-Surgical Management of Periodontal Pocket: A Randomized Clinical Trial DOI Creative Commons

Sushree Ambika Sahu,

Saurav Panda, Abhaya Chandra Das

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(11), P. 1576 - 1576

Published: Oct. 26, 2023

Naturally sourced products like propolis are commonly employed for the non-surgical treatment of periodontal pockets. The use nanoparticle formulations these natural remedies has potential to improve outcomes. aim present study was evaluate efficacy sub-gingivally delivered nanoparticles in management Forty patients diagnosed with periodontitis presenting at least one pocket a probing depth between 4 and 6 mm were selected. Patients randomly assigned into control group (

Language: Английский

Citations

6
Efficacy of injectable platelet rich fibrin (i-PRF) as novel vehicle for local drug delivery (LDD) in non-surgical periodontal pocket therapy - a randomised controlled clinical trial. DOI Creative Commons
Thamaraiselvan Murugan,

Nadathur Doraisamy Jayakumar

Journal of Advanced Periodontology & Implant Dentistry, Journal Year: 2024, Volume and Issue: 16(2), P. 94 - 102

Published: Sept. 11, 2024

Background. The vehicle in a local drug delivery (LDD) system plays vital role delivering the active component at diseased site. Liquid/injectable platelet-rich fibrin (i-PRF), an autologous matrix, might be used as to enmesh drugs and deliver locally periodontally sites. This study evaluated efficacy of (ciprofloxacin [Cip])-loaded i-PRF LDD adjunct subgingival debridement subjects with periodontal pockets. Methods. In parallel design study, 79 pocket sites were randomized 3 groups: group 1 (n=25), scaling root planing (SRP)+i-PRF+Cip; 2 SRP+i-PRF; SRP without any adjunctive intervention. Clinical parameters (probing depth [PD], clinical attachment level [CAL], gingival index [GI], plaque [PI]) microbial quantification (relative levels Aggregatibacter actinomycetemcomitans) assessed from baseline 6th 12th weeks follow-up. Results. All treatment groups showed significant improvements assessed. Group significantly higher PD GI reduction CAL gain decreased relative A. actinomycetemcomitans week, followed by compared 3. Conclusion. Thus, within limits this it can concluded that could considered potential for ciprofloxacin therapy.

Language: Английский

Citations

2
Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic Inflammation with Special Reference to Periodontitis: Current Knowledge and Perspectives DOI
Luigì Santacroce, Eleonora Lo Muzio, Lucrezia Bottalico

et al.

Endocrine Metabolic & Immune Disorders - Drug Targets, Journal Year: 2022, Volume and Issue: 23(4), P. 470 - 484

Published: June 30, 2022

Under steady-state circumstances, the oral microbiota is in equilibrium with host tissues, thus contributing to local and systemic health. Any interruption of such leads a condition dysbiosis proliferation pathogens able cause gingivitis periodontal disease. The mechanisms periodontitis will be described, mostly emphasizing noxious effects exerted by on periodontium either directly or indirectly via release an array mediators, even including pro-inflammatory cytokines, chemokines, enzymes. persistence inflammation ultimately inflammation; therefore, link between obesity, diabetes cardiovascular disease elucidated. Some natural compounds, as polyphenols, prebiotics, probiotics, discussed for their ability exert anti-inflammatory anti-oxidant activities context inflamed buccal cavity systemically, well modulation altered gum-gut microbiota.

Language: Английский

Citations

10
Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use DOI

Lan Lu,

Jingya Wang,

Chongrui Wang

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(2), P. 727 - 754

Published: Nov. 28, 2023

Abstract Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires global action. The occurrence of bacterial pathogens with multi‐drug appeals exploring alternative therapeutic strategies. Antivirulence treatment has been positive substitute in seeking circumvent AMR, which aims target virulence factors directly combat infections. Accumulated evidence suggests that plant‐derived natural products, have utilized treat infectious diseases for centuries, can be abundant sources screening potential virulence‐arresting drugs (VADs) develop advanced therapeutics diseases. This review sums up some their actions various species bacteria, well recent advances pertaining products VAD candidates. Furthermore, we also discuss VAD‐related clinical trials patents, the perspective VAD‐based critical challenges hampering use VADs, genomics‐guided identification therapeutic. These newly discovered VADs will encouraging optimistic candidates may sustainably AMR.

Language: Английский

Citations

5
Exploring the Antimicrobial Efficacy of Tea Tree Essential Oil and Chitosan against Oral Pathogens to overcome the Antimicrobial Resistance Área temática: Microbiologia DOI
Mayara Sanay da Silva Oliveira,

M.J. Paula,

Millena Machado Cardoso

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 196, P. 107006 - 107006

Published: Oct. 12, 2024

Language: Английский

Citations

1
Effectiveness of tea tree oil versus chlorhexidine in the treatment of periodontal diseases: a systematic review DOI
Niharika Singh, Lakshmi Puzhankara, Madhurya N. Kedlaya

et al.

Evidence-Based Dentistry, Journal Year: 2022, Volume and Issue: unknown

Published: July 12, 2022

Language: Английский

Citations

6
Phytotherapy in periodontics as an effective and sustainable supplemental treatment: a narrative review DOI
Abeer Gawish, Mohamed El-Mofty, Safa Jambi

et al.

Journal of Periodontal & Implant Science, Journal Year: 2023, Volume and Issue: 54(4), P. 209 - 209

Published: Dec. 18, 2023

Periodontal disease is a chronic condition caused by microbial infection and mediated the host's immune response. Phytotherapy therapeutic approach that utilizes renewable resource capable of supplying less expensive medicines for world's growing population. This review aimed to present clinical evidence on use complementary medicinal herbs in treatment periodontal diseases.

Language: Английский

Citations

3