Mechanisms of NAFLD development and therapeutic strategies

Nature Medicine, Год журнала: 2018, Номер 24(7), С. 908 - 922

Опубликована: Июнь 29, 2018

Язык: Английский

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Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Journal of Hepatology, Год журнала: 2017, Номер 68(3), С. 526 - 549

Опубликована: Окт. 12, 2017

Язык: Английский

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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

Cell, Год журнала: 2020, Номер 183(1), С. 76 - 93.e22

Опубликована: Сен. 14, 2020

Язык: Английский

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Obesity and nonalcoholic fatty liver disease: current perspectives

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2018, Номер Volume 11, С. 533 - 542

Опубликована: Сен. 1, 2018

Abstract: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic due to an increase in prevalence obesity. The development NASH leads morbidity and mortality. While first line treatment lifestyle modifications, including dietary changes increased physical activity, there are no approved pharmacological agents for NAFLD currently. Due its complex pathophysiology, different pathways under investigation drug with focus on metabolic pathways, inflammation, slowing or reversing fibrosis. There several advancing clinical trials, promising results have been seen drugs that affect hepatic steatosis, This review will provide overview some mechanisms being targeted pharmacologic agents. Keywords: nonalcoholic disease, steatohepatitis, pharmacotherapy, antifibrotics

Язык: Английский

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Therapeutic Landscape for NAFLD in 2020

Gastroenterology, Год журнала: 2020, Номер 158(7), С. 1984 - 1998.e3

Опубликована: Фев. 12, 2020

Язык: Английский

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Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

Metabolism, Год журнала: 2021, Номер 126, С. 154925 - 154925

Опубликована: Ноя. 3, 2021

Язык: Английский

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Hepatocellular Carcinoma: a Narrative Review on Current Knowledge and Future Prospects

Current Treatment Options in Oncology, Год журнала: 2023, Номер 24(7), С. 711 - 724

Опубликована: Апрель 27, 2023

Язык: Английский

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Kaempferol efficacy in metabolic diseases: Molecular mechanisms of action in diabetes mellitus, obesity, non-alcoholic fatty liver disease, steatohepatitis, and atherosclerosis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116694 - 116694

Опубликована: Май 6, 2024

The incidence of metabolic diseases has progressively increased, which a negative impact on human health and life safety globally. Due to the good efficacy limited side effects, there is growing interest in developing effective drugs treat from natural compounds. Kaempferol (KMP), an important flavonoid, exists many vegetables, fruits, traditional medicinal plants. Recently, KMP received widespread attention worldwide due its potential treatment diseases. To promote basic research clinical application KMP, this review provides timely comprehensive summary pharmacological advances four molecular mechanisms action, including diabetes mellitus, obesity, non-alcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), atherosclerosis. According research, shows remarkable therapeutic effects by regulating multiple signaling transduction pathways such as NF-κB, Nrf2, AMPK, PI3K/AKT, TLR4, ER stress. In addition, most recent literature KMP's source, pharmacokinetics studies, well toxicity are also discussed review, thus providing foundation evidence for further studies develop novel Collectively, our manuscript strongly suggested that could be promising candidate

Язык: Английский

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Lubiprostone Reduces Fat Content on MRI‐PDFF in Patients With MASLD: A 48‐Week Randomised Controlled Trial

Alimentary Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

The laxative lubiprostone has been shown to decrease intestinal permeability. We aimed assess the safety and efficacy of administered for 48 weeks in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Язык: Английский

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Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity

Journal of Ethnopharmacology, Год журнала: 2025, Номер 341, С. 119308 - 119308

Опубликована: Янв. 1, 2025

Язык: Английский

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