Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Год журнала: 2022, Номер 2(6)

Опубликована: Май 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Язык: Английский

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Heavy metal ion detection using green precursor derived carbon dots

iScience, Год журнала: 2022, Номер 25(2), С. 103816 - 103816

Опубликована: Янв. 25, 2022

The discovery of carbon dots (CDs) for environmental remediation has gained awareness because the diverse economically viable and friendly green precursors generated from biowastes biomass compared to toxic inorganic quantum CDs prepared chemical precursors. This review presents recent progress in CDs, including their synthesis methods sensing applications detection heavy metal ions such as Iron (III), Mercury (II), Copper Chromium (VI), Lead Arsenic Cobalt Aluminum Silver (I), Gold (III) which are prominent pollutants. comparison based on selectivity, sensitivity, yield, limit, linear concentration range, mechanisms also reported. covers performance doped using heteroatoms, toward ions. Apart future perspectives, this provides a general guide use detect harmful

Язык: Английский

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Biomass-derived carbon dots with pharmacological activity for biomedicine: Recent advances and future perspectives

Science Bulletin, Год журнала: 2024, Номер 69(19), С. 3127 - 3149

Опубликована: Авг. 16, 2024

Язык: Английский

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Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(32), С. 38653 - 38664

Опубликована: Авг. 3, 2023

As a typical chronic inflammatory joint disease with swelling and pain syndromes, rheumatoid arthritis (RA) is closely related to articular lubrication deficiency excessive proinflammatory cytokines in its progression pathogenesis. Herein, inspired by the dual effects of improvement anti-inflammation treat RA, two novel potential therapeutic nanoagents have been developed rationally employing herbal medicine-derived carbon quantum dots (CQDs), i.e., safflower (Carthamus tinctorius L.) CQDs Angelica sinensis CQDs, yielding ultrahigh bioefficacy. In vitro experimental results show that display excellent friction reduction due their good water solubility spherical structure. Using RA rat models, it indicated significantly relieved symptoms inhibited expression cytokines, including IL-1, IL-6, TNF-α, indicating extraordinary Thus, combining lubricating bioefficacy derived from medicine an attractive strategy develop new for treatment.

Язык: Английский

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Green synthesis, characterization and biomedical applications of Centella asiatica-derived carbon dots

Carbon letters, Год журнала: 2023, Номер 33(4), С. 1057 - 1071

Опубликована: Апрель 6, 2023

Язык: Английский

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Herbal Medicine-Inspired Carbon Quantum Dots with Antibiosis and Hemostasis Effects for Promoting Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(7), С. 8527 - 8537

Опубликована: Фев. 8, 2024

Bleeding and bacterial infections are crucial factors affecting wound healing. The usage of herbal medicine-derived materials holds great potential for promoting However, the uncertain intrinsic effective ingredients unclear mechanism action remain concerns. Herein, inspired by medicine Ligusticum wallichii, we reported synthesis tetramethylpyrazine-derived carbon quantum dots (TMP-CQDs) Of note, use TMP as precursor instead L. wallichii ensured repeatability homogeneity obtained products. Furthermore, TMP-CQDs exhibited high antibacterial activity. Mechanically, inhibited DNA repair, biosynthesis, quorum sensing bacteria induced intracellular reactive oxygen species (ROS). Moreover, could accelerate blood coagulation through activating factor VIII platelet aggregation. Effective healing was achieved using in Staphylococcus aureus-infected mouse skin model. This study sheds light on development medicine-inspired therapeutic drugs.

Язык: Английский

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Carbon Dots as Promising Carbon Nanomaterials for Diagnostics, Therapeutics, and Regenerative Orofacial Applications

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106808 - 106808

Опубликована: Март 1, 2025

Язык: Английский

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Green functional carbon dots derived from herbal medicine ameliorate blood—brain barrier permeability following traumatic brain injury

Nano Research, Год журнала: 2022, Номер 15(10), С. 9274 - 9285

Опубликована: Июль 26, 2022

Язык: Английский

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Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Фев. 23, 2023

Acute kidney injury (AKI) refers to a tricky clinical disease, known by its high morbidity and mortality, with no real specific medicine for AKI. The carbonization product from Pollen Typhae (i.e., Pu-huang in China) has been extensively employed clinic, it is capable of relieving the renal damage other diseases China since acient times.Inspired process Traditional Chinese Medicine (TCM), novel species carbon dots derived (PT-CDs) was separated then collected using one-pot pyrolysis method. as-prepared PT-CDs (4.85 ± 2.06 nm) negative charge abundant oxygenated groups exhibited solubility, they were stable water. Moreover, rhabdomyolysis (RM)-induced AKI rat model used, first demonstrated that had significant activity improving level BUN CRE, urine volume index, histopathological morphology RM-induced rats. It noteworthy interventions significantly reduced degree inflammatory reaction oxidative stress, which may be correlated basial potential mechanism anti-AKI activities. Furthermore, cytotoxicity assay biosafety evaluation biocompatibility PT-CDs.This study offers strategy based on suggests related candidate applications.

Язык: Английский

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Green synthesis of boron-doped carbon dots from Chinese herbal residues for Fe3+ sensing, anti-counterfeiting, and photodegradation applications

Journal of Cleaner Production, Год журнала: 2023, Номер 422, С. 138577 - 138577

Опубликована: Авг. 26, 2023

Язык: Английский

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