Regenerative Therapy,
Год журнала:
2024,
Номер
25, С. 355 - 366
Опубликована: Фев. 14, 2024
As
a
prominent
research
area
in
tissue
repair
and
regeneration,
mesenchymal
stem
cells
(MSCs)
have
garnered
substantial
attention
for
their
potential
the
treatment
of
various
diseases.
It
is
now
widely
recognized
that
therapeutic
effects
MSCs
primarily
occur
through
paracrine
mechanisms.
Among
these
mechanisms,
exosomes
play
crucial
role
by
exerting
series
regulatory
on
surrounding
tissues.
While
shown
promise
treating
diseases,
they
do
some
limitations,
such
as
limited
secretion,
poor
targeting,
single
functionality.
However,
MSC
preconditioning
can
enhance
production
exosomes,
lead
to
more
stable
functionality
improve
effects.
Moreover,
could
also
serve
carriers
specific
drugs
or
genes,
enabling
precise
treatments
This
review
summarizes
most
recent
literatures
how
influences
regenerative
provides
new
insights
into
application
derived
from
MSCs.
Life Sciences,
Год журнала:
2024,
Номер
340, С. 122439 - 122439
Опубликована: Янв. 24, 2024
Myocardial
ischemia–reperfusion
injury
(MIRI),
caused
by
the
initial
interruption
and
subsequent
restoration
of
coronary
artery
blood,
results
in
further
damage
to
cardiac
function,
affecting
prognosis
patients
with
acute
myocardial
infarction.
Ferroptosis
is
an
iron-dependent,
superoxide-driven,
non-apoptotic
form
regulated
cell
death
that
involved
pathogenesis
MIRI.
characterized
accumulation
lipid
peroxides
(LOOH)
redox
disequilibrium.
Free
iron
ions
can
induce
oxidative
stress
as
a
substrate
Fenton
reaction
lipoxygenase
(LOX)
participate
inactivation
variety
antioxidants
including
CoQ10
GPX4,
destroying
balance
causing
death.
The
metabolism
amino
acid,
iron,
lipids,
associated
pathways,
considered
specific
hallmark
ferroptosis.
This
review
systematically
summarizes
latest
research
progress
on
mechanisms
ferroptosis
discusses
analyzes
therapeutic
approaches
targeting
alleviate
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25251 - e25251
Опубликована: Фев. 1, 2024
This
review
discusses
recent
experimental
and
clinical
findings
related
to
ferroptosis,
with
a
focus
on
the
role
of
MSCs.
Therapeutic
efficacy
current
applications
MSC-based
ferroptosis
therapies
are
also
discussed.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 21, 2025
Severe
hepatic
steatosis
can
exacerbate
Ischemia–reperfusion
injury
(IRI),
potentially
leading
to
early
graft
dysfunction
and
primary
non-function.
In
this
study,
we
investigated
the
heterogeneity
of
different
subpopulations
Urine-derived
stem
cells
(USCs)
explore
most
suitable
cell
subtype
for
treating
severe
steatotic
liver
IRI.
This
study
utilized
scRNA-seq
Bulk
RNA-seq
investigate
transcriptional
between
Spindle-shaped
USCs
(SS-USCs)
Rice-shaped
(RS-USCs).
Additionally,
rat
fatty
Liver
transplantation
(LT)
model,
mouse
IRI
Steatotic
Hepatocyte
Hypoxia-Reoxygenation
(SHP-HR)
model
were
constructed.
Extracellular
vesicles
derived
from
SS-USCs
RS-USCs
isolated
subjected
mass
spectrometry
analysis.
The
therapeutic
effects
Exosomes
(SS-USCs-Exo)
(RS-USCs-Exo)
explored,
elucidating
their
potential
mechanisms
in
inhibiting
ferroptosis
alleviating
Multiple
omics
analyses
confirmed
that
possess
strong
tissue
repair
antioxidant
capabilities,
while
have
differentiate
towards
specific
directions
such
as
kidney,
nervous
system,
skeletal
particularly
showing
great
application
renal
system
reconstruction.
Further
experiments
demonstrated
vivo
vitro
models
confirming
SS-USCs-Exo
significantly
inhibit
alleviate
IRI,
whereas
RS-USCs/RS-USCs-Exo
are
less
pronounced.
Analysis
comparing
proteomic
differences
RS-USCs-Exo
revealed
primarily
improve
cellular
viability
by
secreting
exosomes
containing
Glutathione
Peroxidase
4
(GPX4)
protein.
highlights
donor
through
presence
GPX4
protein
exosomes.
appropriate
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 7, 2023
Flavonoids
are
a
class
of
bioactive
phytochemicals
containing
core
2-phenylchromone
skeleton
and
widely
found
in
fruits,
vegetables,
herbs.
Such
natural
compounds
have
gained
significant
attention
due
to
their
various
health
benefits.
Ferroptosis
is
recently
discovered
unique
iron-dependent
mode
cell
death.
Unlike
traditional
regulated
death
(RCD),
ferroptosis
associated
with
excessive
lipid
peroxidation
on
cellular
membranes.
Accumulating
evidence
suggests
that
this
form
RCD
involved
variety
physiological
pathological
processes.
Notably,
multiple
flavonoids
been
shown
be
effective
preventing
treating
diverse
human
diseases
by
regulating
ferroptosis.
In
review,
we
introduce
the
key
molecular
mechanisms
ferroptosis,
including
iron
metabolism,
several
major
antioxidant
systems.
Additionally,
summarize
promising
targeting
which
provides
novel
ideas
for
management
such
as
cancer,
acute
liver
injury,
neurodegenerative
diseases,
ischemia/reperfusion
(I/R)
injury.
Cells,
Год журнала:
2023,
Номер
12(2), С. 311 - 311
Опубликована: Янв. 13, 2023
Ferroptosis
is
a
type
of
iron-dependent
cell
death
caused
by
ferrous
iron
overload,
reactive
oxygen
species
generation
through
the
Fenton
reaction,
and
lipid
peroxidation,
leading
to
antioxidative
system
dysfunction
and,
ultimately,
membrane
damage.
The
functional
role
ferroptosis
in
human
physiology
pathology
considered
cause
or
consequence
diseases.
Circulating
exosomes
mediate
intercellular
communication
organ
crosstalk.
They
not
only
transport
proteins
nucleic
acids
derived
from
parental
cells
but
also
serve
as
vehicles
for
targeted
delivery
exogenous
cargo.
Exosomes
regulate
delivering
biological
material
recipient
cell,
affecting
ferroptosis-related
proteins,
transporting
ferritin-bound
out
cell.
This
review
discusses
pathogenesis
mediated
endogenous
therapeutic
potential
In
addition,
this
explores
exosome-mediated
diseases
with
an
emphasis
on
strategies
engineering
therapy.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13336 - 13336
Опубликована: Авг. 28, 2023
As
a
novel
form
of
regulated
cell
death,
ferroptosis
is
characterized
by
intracellular
iron
and
lipid
peroxide
accumulation,
which
different
from
other
death
forms
morphologically,
biochemically,
immunologically.
Ferroptosis
metabolism,
antioxidant
defense
systems
as
well
various
transcription
factors
related
signal
pathways.
Emerging
evidence
has
highlighted
that
associated
with
many
physiological
pathological
processes,
including
cancer,
neurodegeneration
diseases,
cardiovascular
ischemia/reperfusion
injury.
Noncoding
RNAs
are
group
functional
RNA
molecules
not
translated
into
proteins,
can
regulate
gene
expression
in
manners.
An
increasing
number
studies
have
shown
noncoding
RNAs,
especially
miRNAs,
lncRNAs,
circRNAs,
interfere
the
progression
modulating
ferroptosis-related
genes
or
proteins
directly
indirectly.
In
this
review,
we
summarize
basic
mechanisms
regulations
focus
on
recent
mechanism
for
types
ncRNAs
to
conditions,
will
deepen
our
understanding
regulation
provide
new
insights
employing
ferroptosis-associated
therapeutic
strategies.
