Advances in Wound Care, Год журнала: 2024, Номер unknown
Опубликована: Июнь 14, 2024
The combination of hydrogel biomaterials with exosomes to facilitate wound healing and skin regeneration is a promising approach.
Язык: Английский
Trends in biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Journal of Tissue Engineering, Год журнала: 2024, Номер 15
Опубликована: Янв. 1, 2024
The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. intricate healing mechanisms are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels reactive oxygen species (ROS), ischemia, impaired vascularization, altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for treatment owing exceptional biocompatibility resemblance the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize microenvironment alterations occurring in wounds, aiming provide comprehensive understanding its pathogenesis, then classification recently developed be presented, encompassing properties such hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion angiogenesis, pH responsiveness, more. primary objective is offer valuable reference repairing based on unique microenvironment. Moreover, this paper outlines avenues future advancements hydrogel dressings facilitate expedite process wounds.
Язык: Английский
Процитировано
10
Materials Today Bio, Год журнала: 2024, Номер 28, С. 101186 - 101186
Опубликована: Авг. 6, 2024
Diabetic wounds pose a clinical challenge due to persistent inflammation, severe bacterial infections, inadequate vascularization, and pronounced oxidative stress. Current therapeutic modalities fail provide satisfactory outcomes in managing these conditions, resulting considerable patient distress. Two-dimensional nanomaterials (2DNMs), characterized by their unique nanosheet structures, expansive surface areas, remarkable physicochemical properties, have garnered attention for potential applications. Emerging 2DNMs can be loaded with various pharmacological agents, including small molecules, metal ions, liposomes. Moreover, they integrated biomaterials such as hydrogels, microneedles, microspheres, thus demonstrating unprecedented advantages expediting the healing process of diabetic wounds. exhibit exceptional performance characteristics, high biocompatibility, effective antimicrobial optimal phototherapeutic effects, enhanced electrostimulation capabilities. These properties enable them modulate wound microenvironment, leading widespread application tissue repair outcomes. This review delineates several emerging 2DNMs, graphene its derivatives, black phosphorus, MXenes, transition dichalcogenides, context repair. Furthermore, it elucidates translational challenges future perspectives treatments. Overall, present highly promising strategy ameliorating wounds, providing novel avenues diagnostic strategies management.
Язык: Английский
Процитировано
10
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Effective treatment of diabetic wounds remains challenging because multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive antibacterial hydrogel incorporating MXene deferoxamine (DFO)-loaded microspheres is developed for the MDR bacteria-infected wounds. The built based on covalent crosslinking between ε-poly(L-lysine) o-phthalaldehyde-terminated four-arm poly(ethylene glycol). exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, biodegradability. Under near-infrared (NIR) irradiation, converted light into heat elevated local temperature rapidly, enabling rapid disintegration biofilms. Simultaneously, exerted inherent activity, persistently killing planktonic bacteria, effectively controlling wound infections. encapsulated DFO then released from in sustained controlled manner, promoted angiogenesis during healing. Additionally, MXenes can scavenge reactive oxygen species alleviate inflammation. methicillin-resistant Staphylococcus aureus-infected model mice, composite along with NIR irradiation efficiently reduced infectious accelerated healing by promoting alleviating This has great clinical potential wounds, particularly environments involving motion infection.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129515 - 129515
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
8
Pharmaceutical Development and Technology, Год журнала: 2024, Номер 29(7), С. 703 - 718
Опубликована: Июль 18, 2024
Letrozole (LTZ) is used as first-line treatment for hormone-positive breast cancer (BC) in postmenopausal women. However, its poor aqueous solubility and permeability have reduced clinical efficacy. Herein, we developed LTZ-nanotransferosomes (LTZ-NT) to address above mentioned issues. The LTZ-NT were optimized statistically using Design Expert
Язык: Английский
Процитировано
7
Small, Год журнала: 2024, Номер 20(46)
Опубликована: Авг. 7, 2024
Abstract Wound healing is a dynamic process involving the timely transition of organized phases. However, infected wounds often experience prolonged inflammation due to microbial overload. Thus, addressing viable treatment needs across different stages critical challenge in wound management. Herein, novel core‐shell microneedle (CSMN) patch designed for sequential delivery tannic acid‐magnesium (TA‐Mg) complexes and extracellular vesicles from Lactobacillus druckerii (LDEVs). Upon application sites, CSMN@TA‐Mg/LDEV releases TA‐Mg first counteract pathogenic overload reduce reactive oxygen species (ROS), aiding proliferative phase. Subsequently, sustained release LDEVs enhances activities keratinocytes fibroblasts, promotes vascularization, modulates collagen deposition. Notably, track composition demonstrates that can both inhibit aggressive pathogen increase diversity at sites. Functional analysis further highlights potential facilitating skin barrier restoration. Moreover, it confirmed accelerate closure improve post‐recovery quality murine wound. Conclusively, this innovative CSMN offers rapid high‐quality alternative emphasizes significance homeostasis.
Язык: Английский
Процитировано
6
Nanomedicine, Год журнала: 2024, Номер 19(10), С. 915 - 941
Опубликована: Март 6, 2024
Chronic nonhealing wounds pose a serious challenge to regaining skin function and integrity. Platelet-derived extracellular vesicles (PEVs) are nanostructured particles with the potential promote wound healing since they can enhance neovascularization cell migration reduce inflammation scarring. This work provides an innovative overview of technical laboratory issues in PEV production, PEVs' role chronic benefits challenges its clinical translation. The article also explores proper sourcing, extraction techniques storage conditions, discusses necessity further evaluations combinational therapeutics, including dressing biomaterials, M2-derived exosomes, mesenchymal stem cells-derived microneedle technology, boost their therapeutic efficacy as advanced strategies for healing.
Язык: Английский
Процитировано
5
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1850 - 1850
Опубликована: Авг. 14, 2024
Platelet-derived extracellular vesicles (pEVs) are emerging as pivotal players in numerous physiological and pathological processes, extending beyond their traditional roles hemostasis thrombosis. As one of the most abundant vesicle types human blood, pEVs transport a diverse array bioactive molecules, including growth factors, cytokines, clotting facilitating crucial intercellular communication, immune regulation, tissue healing. The unique ability to traverse barriers biocompatibility position them promising candidates for targeted drug delivery regenerative medicine applications. Recent studies have underscored involvement cancer progression, viral infections, wound healing, osteoarthritis, sepsis, cardiovascular diseases, rheumatoid arthritis, atherothrombosis. For instance, promote tumor progression metastasis, enhance repair, contribute thrombo-inflammation diseases such COVID-19. Despite potential, challenges remain, need standardized isolation techniques comprehensive understanding mechanisms action. Current research efforts focused on leveraging innovative anti-cancer treatments, advanced systems, therapies, biomarkers disease diagnosis monitoring. This review highlights necessity overcoming technical hurdles, refining methods, establishing protocols fully unlock therapeutic potential pEVs. By functions applications pEVs, we can advance use clinical settings, ultimately revolutionizing treatment strategies across various medical fields improving patient outcomes.
Язык: Английский
Процитировано
5
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155575 - 155575
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
5