Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

---

A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 16, 2025

RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), most prevalent degenerative joint disease. However, synergistic effects these approaches on attenuating OA progression remain largely unexplored. In this study, matrix metalloproteinase-13 siRNA (siMMP-13) was incorporated onto polyethylenimine (PEI)-polyethylene glycol (PEG) modified Fe3O4 nanoparticles, forming a nucleic acid nanocarrier termed si-Fe NPs. Subsequently, poly(vinyl alcohol) (PVA) crosslinked phenylboronic (PBA)-modified hyaluronic (HA) hydrogel (HPP) used to encapsulate NPs, resulting bifunctional (si-Fe-HPP) with reactive oxygen species (ROS)-responsive RNAi properties. Studies vitro demonstrated that si-Fe-HPP exhibited excellent biocompatibility, anti-inflammatory prolonged stable retention time knee joint. Intra-articular injection significantly attenuated cartilage degradation mice destabilization medial meniscus (DMM)-induced OA. The not only notably alleviated synovitis, osteophyte formation subchondral bone sclerosis, but also markedly improved physical activity reduced pain DMM-induced mice. This study reveals si-Fe-HPP, its ROS-responsive abilities, can protect chondrocytes attenuate progression, providing novel insights directions for development materials treatment.

Язык: Английский

---

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 1583 - 1602

Опубликована: Май 1, 2024

Knee osteoarthritis (KOA) is a persistent degenerative condition characterized by the deterioration of cartilage. The Chinese herbal formula Radix Rehmanniae Praeparata- Angelica Sinensis-Radix Achyranthis Bidentatae (RAR) has often been used in effective prescriptions for KOA as main functional drug, but its underlying mechanism remains unclear. Therefore, network pharmacology and verification experiments were employed to investigate impact mode action RAR treatment KOA.

Язык: Английский

---

Functional Nanomaterials for the Treatment of Osteoarthritis

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6731 - 6756

Опубликована: Июль 1, 2024

Abstract: Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 595 million people worldwide. Nanomaterials possess superior physicochemical properties and can influence pathological processes due to their unique structural features, such as size, surface interface, photoelectromagnetic thermal effects. Unlike traditional OA treatments, which suffer from short half-life, low stability, poor bioavailability, high systemic toxicity, nanotherapeutic strategies for offer longer enhanced targeting, improved reduced toxicity. These advantages effectively address limitations of therapies. This review aims inspire researchers develop multifunctional nanomaterials promote practical application in treatment. Keywords: nanostructures, osteoarthritis, drug delivery systems, nanomedicine, precision medicine

Язык: Английский

---

A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 14, 2024

Abstract Lower back pain (LBP) is a common condition closely associated with intervertebral disc degeneration (IDD), causing significant socioeconomic burden. Inflammatory activation in degenerated discs involves pro-inflammatory cytokines, dysregulated regulatory and increased levels of nerve growth factor (NGF), leading to further destruction sensitization. Macrophage polarization related autophagy. Based on these pathological features, structured biomimetic nanoparticle coated TrkA-overexpressing macrophage membranes (TMNP@SR) rapamycin-loaded mesoporous silica core developed. TMNP@SR acted like sponges adsorbe inflammatory cytokines NGF delivers the autophagy regulator rapamycin (RAPA) into macrophages through homologous targeting effects outer engineered cell membrane. By regulating activation, promoted M1-to-M2 switch avoid continuous inflammation within disc, which prevented apoptosis nucleus pulposus cells. In addition, relieved mechanical thermal hyperalgesia, reduced calcitonin gene-related peptide (CGRP) substance P (SP) expression dorsal root ganglion, downregulated GFAP c-FOS signaling spinal cord rat IDD model. summary, spontaneously inhibits aggravation alleviate reduce ingress sensory nerves, presenting promising treatment strategy for LBP induced by degeneration. Graphical

Язык: Английский

---

EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Авг. 20, 2024

Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, poor solubility off-target activity have limited utility in clinical trials. Additionally, the immune modulatory role of betulinic analogue tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy colorectal cancer (CRC) with lead analogue, named as 2c, carrying 1,2,3-triazole-moiety attached to BA through linker, found more effective than inhibiting CRC cell lines, was chosen here this investigation. Epithelial adhesion molecule (EpCAM) highly overexpressed membrane. A single-stranded short oligonucleotide sequence, aptamer (Apt), that folds into 3D-defined architecture can be used targeting ligand specific binding target protein. EpCAM site-specific homing aptamer-conjugated-2c-loaded nanoparticles (Apt-2cNP) at site enhance therapeutic reduce toxicity normal cells. We vitro vivo efficacy anti-tumorigenic response conjugated CRC-TME.

Язык: Английский

---

Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 22, 2025

Administering medication precisely to the inflamed intestinal sites treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, inflammation damaged mucosa contains a large number amino groups which are positively charged, providing new opportunities for drug delivery system design. Here, we report an oral utilizing tacrolimus-loaded poly (lactic-co-glycolic acid) (TAC/PLGA) particles adhesion coating by in situ UV-triggered polymerization polyacrylic acid and N-hydroxysuccinimide (PAA-NHS). The negatively charged carboxyl effectively interact focal mucosa, NHS ester form covalent bonds groups, thereby synergically enhancing PLGA mucosa. Our findings reveal that, compared naked particles, PAA-NHS increases inflammatory intestine. dextran sulfate sodium-induced acute mouse model, TAC/PLGA exhibits substantial retention TAC within intestine, efficiency therapeutic effects. This approach holds promise UC management, minimizing systemic effects optimizing outcomes.

Язык: Английский

---

Chronic Kidney Disease and Osteoarthritis: Current Understanding and Future Research Directions

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1567 - 1567

Опубликована: Фев. 13, 2025

Chronic kidney disease (CKD) is a significant public health concern. Osteoarthritis (OA), common form of arthritis, has been shown to have dramatically increased prevalence, particularly among individuals aged 40-50 and older, in the presence CKD. Furthermore, CKD may exacerbate progression impact OA. A survey study revealed that 53.9% patients undergoing long-term hemodialysis were diagnosed with These findings underscore potential association between Uremic toxins, such as indoxyl sulfate, p-cresyl transforming growth factor-β, advanced glycation end-products, are regarded risk factors various CKD-related conditions, affecting bone joint metabolism. However, whether these serve bridging mechanism OA comorbidities, well their detailed roles this context, remains unclear. Addressing identifying effective treatment prevention strategies an urgent challenge warrants immediate attention. This review focuses on describing discussing molecular pathological mechanisms underlying CKD-associated possible therapeutic strategies.

Язык: Английский

---

Single-cell data and network pharmacology screen hub genes related to oxidative stress response in myeloid cell of osteoarthritis

Current Pharmaceutical Analysis, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

---

Shikonin-loaded PLGA nanoparticles: A promising strategy for psoriasis treatment

Heliyon, Год журнала: 2024, Номер 10(11), С. e31909 - e31909

Опубликована: Май 24, 2024

Psoriasis is an inflammation-based skin illness marked by aggravated proliferation of epidermal cells. Shikonin a natural naphthoquinone obtained from Arnebiae radix. It exerts anti-inflammatory and immunosuppressive effects. However, the poor water solubility low bioavailability shikonin limit its application. In this study, shikosin-loaded PLGA nanoparticle hydrogel was prepared used to deliver drug epidermis psoriasis mice through local administration. The results demonstrated that nanoparticles inhibited HaCaT cell multiplication, increased uptake, induced apoptosis Results Western blotting assays indicated shikosin down-regulated protein expressions p65 p-p65. Furthermore, mitigated decreased concentrations inflammation-inducing cytokines, i.e., IL17A, IL-17F, IL-22, IL-1β, TNF-α. Taken together, these suggest shikonin-PLGA loaded in system possess promising therapeutic potential for psoriasis.

Язык: Английский

---