Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 24, 2023
In
the
last
few
decades,
practical
use
of
stem
cells
(SCs)
in
clinic
has
attracted
significant
attention
regenerative
medicine
due
to
ability
these
proliferate
and
differentiate
into
other
cell
types.
However,
recent
findings
have
demonstrated
that
therapeutic
capacity
SCs
may
also
be
mediated
by
their
secrete
biologically
active
factors,
including
extracellular
vesicles
(EVs).
Such
submicron
circular
membrane-enveloped
released
from
surface
harbour
bioactive
cargo
form
proteins,
lipids,
mRNA,
miRNA,
regulatory
factors.
Notably,
growing
evidence
indicated
EVs
transfer
content
recipient
greatly
modulate
functional
fate.
Thus,
they
been
recently
envisioned
as
a
new
class
paracrine
factors
cell-to-cell
communication.
Importantly,
activity
immune
system,
playing
an
important
role
regulation
inflammation,
exhibiting
broad
spectrum
immunomodulatory
promotes
transition
pro-inflammatory
pro-regenerative
environment
site
tissue
injury.
Consequently,
interest
is
placed
on
attempts
utilize
clinical
applications
inflammatory-related
dysfunctions
potential
next-generation
alternative
cell-based
approaches.
this
review
we
will
discuss
current
knowledge
biological
properties
SC-derived
EVs,
with
special
focus
inflammatory
response.
We
address
several
disease
models,
vitro
vivo
preclinical,
well
studies.
Finally,
highlight
perspectives
future
challenges
emerging
EV-based
strategies
inflammation-related
diseases
treatment.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
264, С. 130728 - 130728
Опубликована: Март 11, 2024
Exosomes
(EXOs),
minute
membranous
structures
originating
from
diverse
biological
sources,
have
recently
seized
the
attention
of
researchers
due
to
their
theranostic
potential
for
neurological
diseases.
Released
actively
by
various
cells,
including
stem
adipose
tissue,
and
immune
EXOs
wield
substantial
regulatory
influence
over
intricate
landscape
complications,
exhibiting
both
positive
negative
modulatory
effects.
In
AD,
play
a
pivotal
role
in
disseminating
breaking
down
amyloid-β
protein.
Moreover,
derived
mesenchymal
cells
showcase
remarkable
capacity
mitigate
pro-inflammatory
phenotypes
regulating
miRNAs
neurodegenerative
These
vesicles
possess
unique
ability
traverse
blood-brain
barrier,
governing
aggregation
mutant
huntingtin
Understanding
exosomal
functions
within
CNS
holds
significant
promise
enhancing
treatment
efficacy
This
review
intricately
examines
mechanisms
involving
disease
development,
highlighting
therapeutic
prospects
exploring
utility
exosome-based
nanomedicine
complications.
Additionally,
delves
into
challenges
associated
with
drug
delivery
brain,
emphasizing
complexities
inherent
this
critical
aspect
neurotherapeutics.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 12, 2024
Abstract
Exosomes
are
tiny
extracellular
vesicles
secreted
by
most
cell
types,
which
filled
with
proteins,
lipids,
and
nucleic
acids
(non-coding
RNAs,
mRNA,
DNA),
can
be
released
donor
cells
to
subsequently
modulate
the
function
of
recipient
cells.
Skin
photoaging
is
premature
aging
skin
structures
over
time
due
repeated
exposure
ultraviolet
(UV)
evidenced
dyspigmentation,
telangiectasias,
roughness,
rhytides,
elastosis,
precancerous
changes.
associated
aging-related
processes
including,
oxidative
stress,
inflammation,
senescence.
Anti-aging
features
exosomes
have
been
implicated
in
various
vitro
pre-clinical
studies.
Stem
cell-derived
restore
physiological
regenerate
or
rejuvenate
damaged
tissue
through
mechanisms
such
as
decreased
expression
matrix
metalloproteinase
(MMP),
increased
collagen
elastin
production,
modulation
intracellular
signaling
pathways
well
as,
intercellular
communication.
All
these
evidences
promising
for
therapeutic
potential
photoaging.
This
review
aims
investigate
molecular
effects
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7794 - 7794
Опубликована: Июль 16, 2024
Exosomes,
small
membrane-bound
vesicles
secreted
by
cells,
have
gained
significant
attention
for
their
therapeutic
potential.
Measuring
30–100
nm
in
diameter
and
derived
from
various
cell
types,
exosomes
play
a
crucial
role
intercellular
communication
transferring
proteins,
lipids,
RNA
between
cells.
This
review
analyzes
existing
literature
on
the
clinical
applications
of
exosomes.
We
conducted
comprehensive
search
peer-reviewed
articles
trial
data
to
evaluate
benefits,
limitations,
challenges
exosome-based
therapies.
Key
areas
focus
included
regenerative
medicine,
cancer
therapy,
gene
diagnostic
biomarkers.
highlights
vast
In
facilitate
tissue
repair
regeneration.
can
deliver
agents
directly
tumor
serve
as
vectors
delivery.
As
biomarkers,
they
are
useful
diagnosing
diseases.
Challenges
such
isolation,
purification,
characterization
were
identified.
Current
trials
demonstrate
potential
therapies,
though
also
reveal
hurdles.
Regulatory
issues,
including
need
standardization
validation
exosome
products,
critical
advancing
these
While
progress
has
been
made
understanding
biology,
further
research
is
essential
fully
unlock
Addressing
regulatory
successful
application
practice.
provides
concise
overview
exosomes,
emphasizing
both
promise
obstacles
that
be
overcome.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 123 - 123
Опубликована: Янв. 7, 2024
Lung
cancer
demands
innovative
approaches
for
early
detection
and
targeted
treatment.
In
addressing
this
urgent
need,
exosomes
play
a
pivotal
role
in
revolutionizing
both
the
treatment
of
lung
cancer.
Their
remarkable
capacity
to
encapsulate
diverse
range
biomolecules,
traverse
biological
barriers,
be
engineered
with
specific
targeting
molecules
makes
them
highly
promising
diagnostic
markers
precise
drug
delivery
cells.
Furthermore,
an
in-depth
analysis
exosomal
content
biogenesis
offers
crucial
insights
into
molecular
profile
tumors.
This
knowledge
holds
significant
potential
development
therapies
strategies
Despite
notable
progress
field,
challenges
standardization
cargo
loading
persist.
Collaborative
research
efforts
are
imperative
maximize
advance
field
precision
medicine
benefit
patients.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 10, 2024
Abstract
Exosomes
are
small
vesicles
of
endosomal
origin
that
released
by
almost
all
cell
types,
even
those
pathologically
altered.
widely
participate
in
cell-to-cell
communication
via
transferring
cargo,
including
nucleic
acids,
proteins,
and
other
metabolites,
into
recipient
cells.
Tumour-derived
exosomes
(TDEs)
many
important
molecular
pathways
affect
various
hallmarks
cancer,
fibroblasts
activation,
modification
the
tumour
microenvironment
(TME),
modulation
immune
responses,
angiogenesis
promotion,
setting
pre-metastatic
niche,
enhancing
metastatic
potential,
affecting
therapy
sensitivity
resistance.
The
unique
exosome
biogenesis,
composition,
nontoxicity,
ability
to
target
specific
cells
bring
up
their
use
as
promising
drug
carriers
cancer
biomarkers.
In
this
review,
we
focus
on
role
exosomes,
with
an
emphasis
protein
key
mechanisms
promoting
progression.
We
also
briefly
summarise
mechanism
its
structure,
potential
a
signalling
hub
both
normal
pathological
conditions.
International Journal of Oral Science,
Год журнала:
2024,
Номер
16(1)
Опубликована: Янв. 15, 2024
Abstract
Oral
diseases,
such
as
periodontitis,
salivary
gland
and
oral
cancers,
significantly
challenge
health
conditions
due
to
their
detrimental
effects
on
patient’s
digestive
functions,
pronunciation,
esthetic
demands.
Delayed
diagnosis
non-targeted
treatment
profoundly
influence
patients’
prognosis
quality
of
life.
The
exploration
innovative
approaches
for
early
detection
precise
represents
a
promising
frontier
in
medicine.
Exosomes,
which
are
characterized
nanometer-sized
extracellular
vesicles,
secreted
by
virtually
all
types
cells.
As
the
research
continues,
complex
roles
these
intracellular-derived
vesicles
biological
processes
have
gradually
unfolded.
Exosomes
attracted
attention
valuable
diagnostic
therapeutic
tools
ability
transfer
abundant
cargos
intricate
involvement
multiple
cellular
functions.
In
this
review,
we
provide
an
overview
recent
applications
exosomes
within
field
focusing
inflammation-related
bone
diseases
squamous
cell
carcinomas.
We
characterize
exosome
alterations
demonstrate
potential
biomarkers
diagnosis,
highlighting
indicators
diseases.
also
summarize
targeted
therapy
proposed
future
directions
use
clinical
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3562 - 3562
Опубликована: Март 21, 2024
Exosomes
are
extracellular
vesicles
of
endosomal
origin,
ranging
from
30
to
150
nm
in
diameter,
that
mediate
intercellular
transfer
various
biomolecules,
such
as
proteins,
lipids,
nucleic
acids,
and
metabolites.
They
modulate
the
functions
recipient
cells
participate
diverse
physiological
pathological
processes,
immune
responses,
cell-cell
communication,
carcinogenesis,
viral
infection.
Stem
(SCs)
pluripotent
or
multipotent
can
differentiate
into
cell
types.
SCs
also
secrete
exosomes,
which
exhibit
remarkable
therapeutic
potential
for
diseases,
especially
field
regenerative
medicine.
For
example,
exosomes
derived
mesenchymal
stem
(MSCs)
contain
miRNAs
ameliorate
endocrine
disorders,
diabetes
cancer.
(sc-exos)
may
offer
similar
advantages
SCs,
but
with
reduced
risks
challenges.
Sc-exos
have
lower
tumorigenicity,
immunogenicity,
infectivity.
deliver
drugs
more
efficiently
penetrate
deeper
tissues.
In
this
review,
we
provide
an
overview
recent
advances
sc-exos
their
applications
We
elucidate
how
biological
effects
depend
on
molecular
composition.
address
current
challenges
future
directions
using
sc-exos.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 709 - 709
Опубликована: Май 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1189 - 1204
Опубликована: Фев. 1, 2024
Abstract:
Tissue
engineering
holds
great
potential
for
tissue
repair
and
rejuvenation.
Plant-derived
exosome-like
nanoparticles
(ELNs)
have
recently
emerged
as
a
promising
avenue
in
engineering.
However,
there
is
an
urgent
need
to
understand
how
plant
ELNs
can
be
therapeutically
applied
clinical
disease
management,
especially
regeneration.
In
this
review,
we
comprehensively
examine
the
properties,
characteristics,
isolation
techniques
of
ELNs.
We
also
discuss
their
impact
on
immune
system,
compatibility
with
human
body,
role
To
ensure
suitability
engineering,
explore
various
modification
strategies.
Additionally,
provide
insights
into
progress
commercialization
industrial
perspectives
This
review
aims
highlight
regenerative
medicine
by
exploring
current
research
landscape
key
findings.
Keywords:
plant,
nanoparticles,
nanomedicine,
cartilage,
wound,
bone
