Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature DOI Creative Commons

Adhini Kuppuswamy Satheesh Babu,

Chrissa Petersen,

Henry A. Paz

и другие.

Antioxidants, Год журнала: 2023, Номер 12(8), С. 1527 - 1527

Опубликована: Июль 30, 2023

Evidence from our lab and others indicates the vascular effects of dietary blueberries. In present study, we determined blueberries’ dose- time-dependent on diabetic vasculature their association with gut microbes. Seven-week-old db/db male mice were fed a diet supplemented ± freeze-dried wild blueberry powder (FD-BB) for 4, 8, or 12 weeks (three cohorts). Diets contained 0%, 1.23%, 2.46%, 3.7% FD-BB, equivalent to 0, ½, 1, 1.5 human servings blueberries, respectively. The non-diabetic db/+ standard served as controls. Metabolic parameters, inflammation, microbiome assessed. Dietary supplementation FD-BB improved inflammation in without improving systemic milieu all three cohorts. Blueberries diabetes-induced dysbiosis depending dosage treatment duration. Spearman’s correlation indicated that opportunistic microbes commensal positively negatively associated indices blueberries reduced microbe was (Desulfovibrio), increased (Akkermansia). could be potential adjunct strategy beneficially modulate improve complications diabetes.

Язык: Английский

Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship DOI Open Access

Antonio Nesci,

Claudia Carnuccio,

Vittorio Ruggieri

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 9087 - 9087

Опубликована: Май 22, 2023

Several studies in recent years have demonstrated that gut microbiota-host interactions play an important role human health and disease, including inflammatory cardiovascular diseases. Dysbiosis has been linked to not only well-known diseases, such as bowel rheumatoid arthritis, systemic lupus erythematous, but also risk factors, atherosclerosis, hypertension, heart failure, chronic kidney obesity, type 2 diabetes mellitus. The ways the microbiota is involved modulating are multiple related mechanisms. Indeed, microbiome cooperate a metabolically active superorganism, this affects host physiology through metabolic pathways. In turn, congestion of splanchnic circulation associated with edema intestinal wall, altered function permeability barrier result translocation bacteria their products into circulation, further enhancing pro-inflammatory conditions underlying disorders. aim present review describe complex interplay between microbiota, its metabolites, development evolution We discuss possible interventions intended modulate reduce risk.

Язык: Английский

Процитировано

83
Akkermansia muciniphila : A promising probiotic against inflammation and metabolic disorders DOI Creative Commons
Yanqing Zhao, Huijun Yang, Peng Wu

и другие.

Virulence, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 27, 2024

Metabolic disease is a worldwide epidemic that has become public health problem. Gut microbiota considered to be one of the important factors maintain human by regulating host metabolism. As an abundant bacterium in gut,

Язык: Английский

Процитировано

16
Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension DOI Creative Commons
Patrizia Dardi, Camille Perella Coutinho,

Sarah de Oliveira

и другие.

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107621 - 107621

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy DOI Creative Commons
Vicky Yao,

Nairui Fan,

Shuxia Ma

и другие.

MedComm, Год журнала: 2025, Номер 6(5)

Опубликована: Апрель 18, 2025

ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized

Язык: Английский

Процитировано

1
Gut Microbiome in Children with Congenital Heart Disease After Cardiopulmonary Bypass Surgery (GuMiBear Study) DOI Creative Commons
Fatma Koç, Claire Magner, Kiera Murphy

и другие.

Pediatric Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

Abstract The gut microbiome of infants with congenital heart disease (CHD) undergoing cardiopulmonary bypass surgery (CPB) is at risk profound alteration. aim this study was to examine the pre- and post-bypass explore potential implications altered biodiversity. A prospective cohort involving CHD who underwent CPB performed. Faecal samples were collected from alongside collection demographic clinical data in order changes before after surgery. 16S rRNA sequencing analysis performed on DNA isolated stool determine composition. Thirty-three patients recruited, thirteen these available for final analysis. Compared healthy, matched controls, a genus level, pre-operative demonstrated higher relative abundance Escherichia-Shigella (31% vs 2–6%) lower Bifidobacterium (13% 40–60%). In post-operative samples, (35%), Enterococcus (11%), Akkermansia (6%), Staphylococcus (5%) than pre-op samples. One infant developed necrotising-enterocolitis (NEC). They displayed marked (93%) pre-operatively. This demonstrates that have an when compared healthy controls there might be possible link between virulent species NEC.

Язык: Английский

Процитировано

6
The interplay between microbial metabolites and macrophages in cardiovascular diseases: A comprehensive review DOI

Yongzheng Yang,

Sajad Karampoor, Rasoul Mirzaei

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 121, С. 110546 - 110546

Опубликована: Июнь 25, 2023

Язык: Английский

Процитировано

11
Butyrogenic, bifidogenic and slight anti-inflammatory effects of a green kiwifruit powder (Kiwi FFG®) in a human gastrointestinal model simulating mild constipation DOI
Elizabeth Goya‐Jorge, Pauline Bondue, Irma Gonza

и другие.

Food Research International, Год журнала: 2023, Номер 173, С. 113348 - 113348

Опубликована: Авг. 20, 2023

Язык: Английский

Процитировано

10
Gut Microbiota and Its Role in the Brain-Gut-Kidney Axis in Hypertension DOI
Natalia G. Vallianou, Dimitris Kounatidis, Fotis Panagopoulos

и другие.

Current Hypertension Reports, Год журнала: 2023, Номер 25(11), С. 367 - 376

Опубликована: Авг. 26, 2023

Язык: Английский

Процитировано

10
Influence of Chronic Dietary Nitrate on Downstream Atherogenic Metabolites and the Enteral Microbiome—A Double-Blind Randomized Controlled Trial DOI Creative Commons
Daniel Messiha, Matthias Rinke, Andrew Amos

и другие.

Dietetics, Год журнала: 2025, Номер 4(1), С. 1 - 1

Опубликована: Янв. 10, 2025

Background: Inorganic nitrate is abundant in leafy green vegetables and has been shown to exert positive cardiovascular effects through nitric oxide-related pathways. The enteral microbiome an emerging key player diseases depends on dietary habits. Whether inorganic impacts the atherosclerosis-associated microbiome-dependent metabolites like short chain fatty acids (SCFA) trimethylamine N-oxide (TMAO) unknown. Methods: In a double-blind randomized controlled trial, 30 healthy volunteers were included who either received (0.12 mmol/kg bodyweight) or placebo (equimolar amounts of sodium chloride) for days. TMAO SCFA analyzed. was analyzed by 16S-rRNA sequencing at baseline follow-up. Results: Systolic blood pressure decreased after supplementation (baseline 124.73 mmHg vs. follow up 120 mmHg, p < 0.05) with no change controls. Dietary increased levels (nitrate 349.28 μ/L follow-up 481.15 μ/L, 0.05), while remained unchanged. relative abundance Akkermansia taxa Clostridiales higher individuals high compared normal supplementation, Shannon diversity, richness evenness did not differ between both groups. Conclusions: Our results indicate that associated alterations impact proatherogenic metabolites. Further work warranted investigate causal relationship nutrients, downstream

Язык: Английский

Процитировано

0
Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice DOI Creative Commons
Xiaotong Zhang,

Yanran Yin,

Yongjun Chen

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114667 - 114667

Опубликована: Апрель 16, 2025

The gut microbiome has been closely linked to obstructive sleep apnea (OSA)-associated hypertension (HTN). However, its precise role in the pathogenesis of OSA-induced HTN remains unclear. To clarify causal relationship between dysbiosis and OSA-related HTN, C57BL6J mice were randomly assigned four groups. Each group underwent fecal microbiota transplantation from healthy individuals (control), OSA patients (OSA group), with pre-hypertension (OSA-pHTN or (OSA-HTN group). pro-hypertensive effects verified, composition function compared using 16S rDNA gene sequencing. Additionally, microbiota-related lipopolysaccharide (LPS)/ Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) pathway aortic tissues was investigated. Fecal induced increased systolic blood pressure injury OSA, OSA-pHTN OSA-HTN groups, whereas no significant observed control group. These three groups exhibited impaired intestinal barrier as evidenced by a reduction Akkermansia decreased expression zonula occludens-1 Occludin proteins. In addition, LPS, TLR4 phosphorylated NF-κB tissue immunofluorescence showed upregulation endothelial cells controls. This study demonstrates mediated through gut-derived LPS/TLR4/NF-κB pathway. findings may guide development therapeutic strategies focused on restoring homeostasis.

Язык: Английский

Процитировано

0